Pål Møller
A5089598316- BRCA gene mutations in cancer
- Genetic factors in colorectal cancer
- Cancer Genomics and Diagnostics
- Ovarian cancer diagnosis and treatment
- Colorectal Cancer Screening and Detection
- Genomic variations and chromosomal abnormalities
- Nutrition, Genetics, and Disease
- Spondyloarthritis Studies and Treatments
- DNA Repair Mechanisms
- Psoriasis: Treatment and Pathogenesis
- Global Cancer Incidence and Screening
- Genetic Associations and Epidemiology
- Genomics and Rare Diseases
- Prenatal Screening and Diagnostics
- Multiple and Secondary Primary Cancers
- Cancer Risks and Factors
- Colorectal Cancer Treatments and Studies
- CRISPR and Genetic Engineering
- Dermatological and Skeletal Disorders
- Colorectal and Anal Carcinomas
- Systemic Lupus Erythematosus Research
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Prostate Cancer Treatment and Research
- Reproductive Biology and Fertility
- Family Support in Illness
Oslo University Hospital
2016-2025
Norwegian Cancer Society
2015-2024
Vanderbilt University Medical Center
2023
Helios Universitätsklinikum Wuppertal
2017-2021
International Society for Gastrointestinal Hereditary Tumours
2021
St Mark's Hospital
2021
University of Oslo
1987-2020
Witten/Herdecke University
2017-2020
Radboud University Nijmegen
2001-2018
Radboud University Medical Center
2001-2018
<h3>Background</h3> The UK introduced financial incentives for management of atrial fibrillation (AF) in 2006, after which there was an increase the proportion AF patients diagnosed as resolved. Removal Scotland provides a natural experiment to investigate effects withdrawal incentive on diagnosis resolved AF. <h3>Aim</h3> Investigate introduction and <h3>Design & setting</h3> Cohort study large database primary care records, before April 2006 Scotland, England Northern Ireland, their...
Familial adenomatous polyposis (FAP) is a well-described inherited syndrome, which responsible for <1% of all colorectal cancer (CRC) cases. The syndrome characterised by the development hundreds to thousands adenomas in colorectum. Almost patients will develop CRC if they are not identified and treated at an early stage. as autosomal dominant trait caused mutations APC gene. Recently, second gene has been that also gives rise colonic polyposis, although phenotype less severe than typical...
The purposes of this study were to estimate the reduction in risk ovarian, fallopian tube, or peritoneal cancer women with a BRCA1 BRCA2 mutation after oophorectomy, by age oophorectomy; impact prophylactic oophorectomy on all-cause mortality; and 5-year survival associated clinically detected occult, cancers diagnosed cohort.Women identified from an international registry; 5,783 completed baseline questionnaire ≥ one follow-up questionnaires. Women observed until either diagnosis cancer,...
Pathogenic variants affecting MLH1, MSH2, MSH6, and PMS2 cause Lynch syndrome result in different but imprecisely known cancer risks. This study aimed to provide age organ-specific risks according gene gender determine survival after cancer.We conducted an international, multicenter prospective observational using independent test validation cohorts of carriers class 4 or 5 variants. After the were merged providing 6350 participants 51,646 follow-up years.There 1808 prospectively observed...
Objective Estimates of cancer risk and the effects surveillance in Lynch syndrome have been subject to bias, partly through reliance on retrospective studies. We sought establish more robust estimates patients undergoing prospective surveillance. Design undertook a multicentre study carrying syndrome-associated mutations affecting MLH1 , MSH2 MSH6 or PMS2 . Standardised information surveillance, cancers outcomes were collated an Oracle relational database analysed by age, sex mutated gene....
Background Most patients with path_MMR gene variants (Lynch syndrome (LS)) now survive both their first and subsequent cancers, resulting in a growing number of older LS for whom limited information exists respect to cancer risk survival. Objective design This observational, international, multicentre study aimed determine prospectively observed incidences cancers survival carriers up 75 years age. Results 3119 were followed total 24 475 years. Cumulative at (risks) colorectal 46%, 43% 15%...
The scientific exploration of prepsychotic detection and intervention in psychosis has just commenced. To identify developing at prodromal stages, it is important to learn how patients families perceive initial prodromes naturalistically. We must understand better what we are going detect, because the essential components this phase, particularly subjective experiences, remain unsettled. In a series 19 first episode DSM-IV schizophrenia patients, explore phenomena depth potential core...
The purpose of this study was to estimate the extent protection offered against breast cancer by prophylactic oophorectomy in carriers BRCA1 or BRCA2 mutations and determine what risk reduction varies with age at oophorectomy, diagnosis, time elapsed since surgery.We analyzed 1,439 patients 1,866 matched controls derived from a registry carriers. We estimated odds ratios (ORs) for having had bilateral using conditional logistic regression, parity oral contraceptive use.A previous history...
Germ-line mutations in DNA mismatch-repair genes (MSH2, MLH1, PMS1, PMS2, and MSH6 ) cause susceptibility to hereditary nonpolyposis colorectal cancer. We assessed the prevalence of MSH2 MLH1 families suspected having cancer evaluated whether clinical findings can predict outcome genetic testing.
Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominant disease characterized by the clustering of cancer, endometrial and various other cancers. The caused mutations in DNA-mismatch-repair (MMR) genes, most frequently MLH1, MSH2, MSH6. aims present study were to compare risk developing colorectal, endometrial, cancers between families with MMR-gene mutations.Clinical pathologic data collected from 138 HNPCC. Mutation analyses performed for all families. Survival analysis...
Several options for cancer prevention are available women with a BRCA1 or BRCA2 mutation, including prophylactic surgery, chemoprevention and screening. The authors report on preventive practices in mutations from 9 countries examine differences uptake according to country. Women mutation were contacted after receiving their genetic test result questioned regarding practices. Information was recorded mastectomy, oophorectomy, use of tamoxifen screening (MRI mammography). Two thousand six...
Germline mutations in BRCA1 and BRCA2 predispose to pancreatic cancer. We estimated the incidence of cancer a cohort female carriers mutation. also survival rates cases from families with BRCA followed 5149 women mutation for new The standardised ratios (SIR) were calculated based on age group country residence. reviewed pedigrees 8140 or those case recorded year diagnosis death 351 identified cases. Eight incident among all carriers. SIR was 2.55 (95% CI=1.03–5.31, P=0.04) 2.13...
There are no internationally agreed upon clinical guidelines as to which women with gynecological cancer would benefit from Lynch syndrome screening or how best manage the risk of in syndrome. The Manchester International Consensus Group was convened April 2017 address this unmet need. aim develop clear and comprehensive guidance regarding management sequelae based on existing evidence expert opinion medical professionals patients.
Background: Whether oophorectomy reduces breast cancer risk among BRCA mutation carriers is a matter of debate. We undertook prospective analysis bilateral and in carriers. Methods: Subjects had no history cancer, both breasts intact, information on status (n = 3722). Women were followed until diagnosis, prophylactic mastectomy, or death. A Cox regression model was used to estimate the hazard ratios (HRs) 95% confidence intervals (CIs) associated with (coded as time-dependent variable). All...
Lynch syndrome due to pathogenic variants in the DNA mismatch repair genes MLH1, MSH2, and MSH6 is predominantly associated with colorectal endometrial cancer, although extracolonic cancers have been described within tumor spectrum. However, age-specific cumulative risk (penetrance) of these still poorly defined for PMS2-associated syndrome. Using a large data set from worldwide collaboration, our aim was determine accurate penetrance measures carriers heterozygous PMS2 variants.
Patients with early-onset colorectal cancer (eoCRC) are managed according to guidelines that not age-specific. A multidisciplinary international group (DIRECt), composed of 69 experts, was convened develop the first evidence-based consensus recommendations for eoCRC.
Magnetic resonance imaging (MRI) surveillance is offered to women with a pathogenic variant in the BRCA1 or BRCA2 gene who face high lifetime risk of breast cancer. Surveillance MRI effective downstaging cancers, but association mortality has not been well defined.
SummaryPTEN, a protein tyrosine phosphatase with homology to tensin, is tumor-suppressor gene on chromosome 10q23. Somatic mutations in PTEN occur multiple tumors, most markedly glioblastomas. Germ-line are responsible for Cowden disease (CD), rare autosomal dominant multiple-hamartoma syndrome. was sequenced from constitutional DNA 25 families. were detected all of five families both breast cancer and CD, one family juvenile polyposis syndrome, four thyroid tumors. In this last case, signs...