Oliver G. Denton

ORCID: 0000-0003-1314-8904
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About
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Research Areas
  • Genetic factors in colorectal cancer
  • Cancer Genomics and Diagnostics
  • Cancer-related molecular mechanisms research
  • Surgical Simulation and Training
  • Augmented Reality Applications
  • Botulinum Toxin and Related Neurological Disorders
  • Academic Writing and Publishing
  • Colorectal Cancer Surgical Treatments
  • Colorectal Cancer Screening and Detection
  • Anatomy and Medical Technology
  • Nasal Surgery and Airway Studies
  • Ear Surgery and Otitis Media
  • Virtual Reality Applications and Impacts
  • Sinusitis and nasal conditions
  • 3D Printing in Biomedical Research
  • Periodontal Regeneration and Treatments
  • Enhanced Recovery After Surgery
  • Surgical site infection prevention

University of Strathclyde
2024

NHS Greater Glasgow and Clyde
2020-2024

University of Glasgow
2024

NHS Lanarkshire
2022

Monklands Hospital
2022

Glasgow Royal Infirmary
2020-2021

Cardiff University
2019-2021

Mev Dominguez‐Valentin Julian R. Sampson Toni T. Seppälä Sanne W. ten Broeke John‐Paul Plazzer and 83 more Sigve Nakken Christoph Engel Stefan Aretz Mark A. Jenkins Lone Sunde Inge Bernstein Gabriel Capellá Francesc Balaguer Huw Thomas D. Gareth Evans John Burn Marc S. Greenblatt Eivind Hovig Wouter H. de Vos tot Nederveen Cappel Rolf H. Sijmons Lucio Bertario Maria Grazia Tibiletti Giulia Martina Cavestro Annika Lindblom Adriana Della Valle Francisco López‐Köstner Nathan Gluck Lior H. Katz Karl Heinimann Carlos Vaccaro Reinhard Büttner Heike Görgens Elke Holinski‐Feder Monika Morak Stefanie Holzapfel Robert Hüneburg Magnus von Knebel Doeberitz Markus Loeffler Nils Rahner Hans K. Schackert Verena Steinke‐Lange Wolff Schmiegel Deepak Vangala Kirsi Pylvänäinen Laura Renkonen‐Sinisalo John L. Hopper Aung Ko Win Robert W. Haile Noralane M. Lindor Steven Gallinger Loı̈c Le Marchand Polly A. Newcomb Jane C. Figueiredo Stephen N. Thibodeau Karin Wadt Christina Therkildsen Henrik Okkels Zohreh Ketabi Leticia Moreira Ariadna Sánchez Miquel Serra‐Burriel Marta Pineda Matilde Navarro Ignacio Blanco Kate Green Fiona Lalloo Emma J. Crosbie James Hill Oliver G. Denton Ian M. Frayling Einar Andreas Rødland Hans F. A. Vasen Miriam Mints Florencia Neffa Patricia Esperón Karin Álvarez Revital Kariv Guy Rosner Tamara Alejandra Piñero María Laura González Pablo Kalfayan Douglas Tjandra Ingrid Winship Finlay Macrae Gabriela Möslein Jukka‐Pekka Mecklin Maartje Nielsen Pål Møller

Pathogenic variants affecting MLH1, MSH2, MSH6, and PMS2 cause Lynch syndrome result in different but imprecisely known cancer risks. This study aimed to provide age organ-specific risks according gene gender determine survival after cancer.We conducted an international, multicenter prospective observational using independent test validation cohorts of carriers class 4 or 5 variants. After the were merged providing 6350 participants 51,646 follow-up years.There 1808 prospectively observed...

10.1038/s41436-019-0596-9 article EN cc-by-nc-sa Genetics in Medicine 2019-07-23
Mev Dominguez‐Valentin Emma J. Crosbie Christoph Engel Stefan Aretz Finlay Macrae and 83 more Ingrid Winship Gabriel Capellá Huw Thomas Sigve Nakken Eivind Hovig Maartje Nielsen Rolf H. Sijmons Lucio Bertario Bernardo Bonanni Maria Grazia Tibiletti Giulia Martina Cavestro Miriam Mints Nathan Gluck Lior H. Katz Karl Heinimann Carlos Vaccaro Kate Green Fiona Lalloo James Hill Wolff Schmiegel Deepak Vangala Claudia Perne Hans-Georg Strauß Johanna Tecklenburg Elke Holinski‐Feder Verena Steinke‐Lange Jukka‐Pekka Mecklin John‐Paul Plazzer Marta Pineda Matilde Navarro Joan Brunet Revital Kariv Guy Rosner Tamara Alejandra Piñero María Laura González Pablo Kalfayan Neil Ryan Sanne W. ten Broeke Mark A. Jenkins Lone Sunde Inge Bernstein John Burn Marc S. Greenblatt Wouter H. de Vos tot Nederveen Cappel Adriana Della Valle Francisco Lopez-Koestner Karin Álvarez Reinhard Büttner Heike Görgens Monika Morak Stefanie Holzapfel Robert Hüneburg Magnus von Knebel Doeberitz Markus Loeffler Nils Rahner Jürgen Weitz Kirsi Pylvänäinen Laura Renkonen‐Sinisalo Anna Lepistö Annika Auranen John L. Hopper Aung Ko Win Robert W. Haile Noralane M. Lindor Steven Gallinger Loı̈c Le Marchand Polly A. Newcomb Jane C. Figueiredo Stephen N. Thibodeau Christina Therkildsen Henrik Okkels Zohreh Ketabi Oliver G. Denton Einar Andreas Rødland Hans F. A. Vasen Florencia Neffa Patricia Esperón Douglas Tjandra Gabriela Möslein Julian R. Sampson D. Gareth Evans Toni T. Seppälä Pål Møller

10.1038/s41436-020-01029-1 article EN Genetics in Medicine 2020-12-01

PurposeThis study aimed to report the uptake of hysterectomy and/or bilateral salpingo-oophorectomy (BSO) prevent gynaecological cancers (risk-reducing surgery [RRS]) in carriers pathogenic MMR (path_MMR) variants.MethodsThe Prospective Lynch Syndrome Database (PLSD) was used investigate RRS by a cross-sectional 2292 female path_MMR aged 30–69 years.ResultsOverall, 144, 79, and 517 underwent risk-reducing hysterectomy, BSO, or both combined, respectively. Two-thirds procedures before 50...

10.1016/j.ejca.2021.02.022 article EN cc-by European Journal of Cancer 2021-03-18

Abstract Objective Rate of learning is often cited as a deterrent in the use endoscopic ear surgery. This study investigated curves novice surgeons performing simulated surgery using either an endoscope or microscope. Methods A prospective multi-site clinical research was conducted. Seventy-two medical students were randomly allocated to microscope group, and performed 10 myringotomy ventilation tube insertions. Trial times used produce curves. From these, slope (learning rate) asymptote...

10.1017/s0022215120001188 article EN The Journal of Laryngology & Otology 2020-06-01

Acute recurrent tonsillitis is a chronic, biofilm-related infection that significant burden to patients and healthcare systems. It often treated with repeated courses of antibiotics, which contributes antimicrobial resistance. Studying biofilms key understanding this disease. In vitro modelling using 3D bioprinted hydrogels promising approach achieve this. A novel gelatin-PEGDA pseudomonas fluorescens-laden bioink was developed in hydrogel construct fabricated computer-aided design mimic the...

10.3390/bioengineering11030202 article EN cc-by Bioengineering 2024-02-21

Abstract Background Three-dimensional endoscopes provide a stereoscopic view of the operating field, facilitating depth perception compared to two-dimensional systems, but are not yet widely accepted. Existing research addresses performance and preference, there no studies that quantify anatomical orientation in endoscopic ear surgery. Methods Participants ( n = 70) were randomised starting with either or three-dimensional endoscope system perform one two tasks: using labelled printed...

10.1017/s002221512200010x article EN The Journal of Laryngology & Otology 2022-01-10

Abstract Introduction Surgical site infections (SSI) are responsible for one third of all inpatient and associated with increased morbidity extended hospital stay. The colorectal department at Glasgow Royal Infirmary introduced the Jubilee dressing method in August 2019 aim reducing SSI incidence. Method Closed loop audit elective laparotomies pre- post-introduction (March – July & December 2019). Literature reviews informed selection baseline characteristics relevant to SSI. Analysis by...

10.1093/bjs/znab134.403 article EN British journal of surgery 2021-05-01
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