A5017382453- Colorectal Cancer Surgical Treatments
- Radiomics and Machine Learning in Medical Imaging
- Colorectal Cancer Screening and Detection
- Colorectal and Anal Carcinomas
- Advanced Radiotherapy Techniques
- Colorectal Cancer Treatments and Studies
- Gastric Cancer Management and Outcomes
- Advanced X-ray and CT Imaging
- Medical Imaging Techniques and Applications
- Lung Cancer Diagnosis and Treatment
- AI in cancer detection
- Clinical practice guidelines implementation
- Breast Cancer Treatment Studies
- Cancer Genomics and Diagnostics
- Prostate Cancer Diagnosis and Treatment
- Advances in Oncology and Radiotherapy
- Uterine Myomas and Treatments
- Radiation Dose and Imaging
- Childhood Cancer Survivors' Quality of Life
- Breast Lesions and Carcinomas
- Sarcoma Diagnosis and Treatment
- Anorectal Disease Treatments and Outcomes
- Biomedical Text Mining and Ontologies
- Nutrition and Health in Aging
- Palliative Care and End-of-Life Issues
Agostino Gemelli University Polyclinic
2013-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2019-2025
University of Padua
2024
Università Cattolica del Sacro Cuore
2010-2023
Great Ormond Street Hospital for Children NHS Foundation Trust
2022
Leiden University
2021
Erasmus MC Cancer Institute
2021
Maastro Clinic
2017
Maastricht University Medical Centre
2017
University of Huddersfield
2017
Patients with early-onset colorectal cancer (eoCRC) are managed according to guidelines that not age-specific. A multidisciplinary international group (DIRECt), composed of 69 experts, was convened develop the first evidence-based consensus recommendations for eoCRC.
BackgroundThe impact of body composition and sarcopenia in locally advanced rectal cancer (LARC) is still unclear, even several studies have been published on this issue. Our study aims to analyze the neoadjuvant chemoradiotherapy (nCRT) tolerance survival outcomes.MethodsThis a retrospective, monocentric where LARC patients treated between 2010 2020 were enrolled. A single slice, from pre-therapy simulation computed tomography (CT) scan, was used perform analysis with dedicated software....
Purpose Distant metastases are currently the main cause of treatment failure in locally advanced rectal cancer (LARC) patients. The aim this research is to investigate a correlation between variation radiomics features using pre- and post-neoadjuvant chemoradiation (nCRT) magnetic resonance imaging (MRI) with 2 years distant metastasis (2yDM) rate LARC Methods Materials Diagnostic post- nCRT MRI patients, treated single institution from May 2008 June 2015 an adequate follow-up time, were...
Abstract Background Neoadjuvant chemoradiation therapy (nCRT) is the standard treatment modality in locally advanced rectal cancer (LARC). Since response to radiotherapy (RT) dose dependent cancer, escalation may lead higher complete rates. The possibility predict patients who will achieve (CR) fundamental. Recently, an early tumour regression index (ERI) was introduced pathological CR (pCR) after nCRT LARC patients. primary endpoints be increase of rate and evaluation feasibility delta...
The aim of this work was to apply the 'win ratio' compare outcomes rectal-sparing approaches [watch and wait (WW) local excision (LE)] in management locally advanced rectal cancer responding neoadjuvant chemoradiotherapy. Patients enrolled ReSARCh study (NCT02710812) between 2016 2021 were divided into two cohorts (WW vs. LE). win ratio calculated by dividing number successes (or wins) WW group LE on matched pairs. Oncological (overall survival, distant recurrence), presence a stoma rectum...
Young-onset rectal cancer, in patients less than 50 years, is expected to increase the coming years. A watch-and-wait strategy nowadays increasingly practised with a clinical complete response (cCR) after neoadjuvant treatment. Nevertheless, there may be reluctance offer organ preservation treatment young owing potentially higher oncological risk. This study compared aged years those or more identify possible differences outcomes of watch and wait.The analysed data from cCR therapy whom...
Patients (pts) affected with locally advanced rectal cancer (LARC) may respond differently to neoadjuvant chemoradiotherapy (nCRT). The identification of reliable biomarkers able predict oncological outcomes could help in the development risk-adapted treatment strategies. It has been suggested that inflammation parameters have a role predicting tumor response nCRT and survival cancer, but no definitive conclusion can be drawn at present. aim current study is evaluate baseline inflammatory...
SUMMARY The interaction between implementation of new technologies and different outcomes can allow a broad range researches to be expanded. purpose this paper is introduce the VAlidation high TEchnology based on large database analysis by learning machine (VATE) project that aims combine with related rectal cancer in terms tumor control normal tissue sparing. Using automated computer bots knowledge for screening data it possible identify factors mostly influence those outcomes....
Aims: Between 11 to 14% of patients with locally advanced rectal cancer (LARC) have positive lateral pelvic lymph nodes (LPLN) at diagnosis, related a worse prognosis 5-year survival rate between 30 40%. The best treatment choice for this group is still challenge. optimal radiotherapy (RT) dose LPLN has been investigated. Methods: We retrospectively collected data from LARC the primary staging MRI, treated in our center March 2003 December 2020. Patients underwent neoadjuvant concomitant...