A5053408500- Head and Neck Cancer Studies
- Advanced Radiotherapy Techniques
- Radiomics and Machine Learning in Medical Imaging
- Breast Cancer Treatment Studies
- Glioma Diagnosis and Treatment
- Lung Cancer Diagnosis and Treatment
- Colorectal and Anal Carcinomas
- Management of metastatic bone disease
- Radiopharmaceutical Chemistry and Applications
- Brain Metastases and Treatment
- Oral health in cancer treatment
- Head and Neck Surgical Oncology
- Lung Cancer Treatments and Mutations
- Colorectal Cancer Surgical Treatments
- Advances in Oncology and Radiotherapy
- Medical Imaging Techniques and Applications
- Breast Lesions and Carcinomas
- Endometrial and Cervical Cancer Treatments
- Prostate Cancer Treatment and Research
- Cancer Immunotherapy and Biomarkers
- Multiple Myeloma Research and Treatments
- Pancreatic and Hepatic Oncology Research
- Cancer Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Radiation Dose and Imaging
Ospedale Policlinico San Martino
2015-2024
University of Genoa
2013-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2013-2017
Martin University
2017
National Cancer Research Institute
2014-2017
Hôpital Beau-Séjour
2016
Alleanza Contro il Cancro
2010-2015
Metastasis-directed therapy (MDT) has been tested in clinical trials as a treatment option for oligorecurrent prostate cancer (PCa). However, there is an ongoing debate regarding the impact of using different imaging techniques interchangeably defining lesions and guiding MDT within trials. <b>Methods:</b> We retrospectively identified PCa patients who had 5 or fewer nodal, bone, visceral metastases detected by choline prostate-specific membrane antigen (PSMA) PET/CT underwent stereotactic...
Background: Oropharyngeal mucositis occurs in virtually all patients with head and neck cancer receiving radiochemotherapy. The manipulation of the oral cavity microbiota represents an intriguing challenging target. Patients Methods: A total 75 were enrolled to receive Lactobacillus brevis CD2 lozenges or care regimen sodium bicarbonate mouthwashes. primary endpoint was incidence grade 3 4 oropharyngeal during radiotherapy treatment. Results: There no statistical difference 3-4 between...
BackgroundTo retrospectively evaluate the difference in terms of pathologic complete response (pCR) according to time elapsed between chemoradiation (CRT) and total mesorectal excision (TME) on a large unselected real-life dataset locally advanced rectal cancer (LARC) patients.MethodsA multicentre retrospective cohort study LARC patients from 21 Italian Radiotherapy Institutions was performed. Patients were stratified into 3 different intervals CRT. The 1st group included 300 who underwent...
Aim: The purpose of the present multicentric study was to review stereotactic body radiotherapy (SBRT) with or without chemotherapy (CHT) experience in locally advanced pancreatic cancer (LAPC). Endpoints were overall survival (OS), local control (LC), and distant metastasis-free (DMFS). Several parameters9 impact on these outcomes assessed. Materials Methods: Fifty-six patients LAPC undergoing SBRT+/-CHT included. SBRT median BED<sub>α/β10Gy</sub> 48.0 Gy (range=28.0-78.7). Survival curves...
Patients (pts) affected with locally advanced rectal cancer (LARC) may respond differently to neoadjuvant chemoradiotherapy (nCRT). The identification of reliable biomarkers able predict oncological outcomes could help in the development risk-adapted treatment strategies. It has been suggested that inflammation parameters have a role predicting tumor response nCRT and survival cancer, but no definitive conclusion can be drawn at present. aim current study is evaluate baseline inflammatory...
To evaluate stereotactic body radiotherapy (SBRT) in low-risk Prostate Cancer patients as preferred treatment option emergency health conditions.From April 2013 to September 2015, 28 with prostate cancer were prospectively enrolled. The SBRT prescribed dose was 36.25 Gy 5 fractions, twice a week. Primary endpoints acute and late toxicity. Secondary biochemical recurrence free survival (bRFS) overall survival.Median follow-up 65.5 months (range 52-81). No G3 or G4 toxicity recorded. Acute G1...
To report the long-term outcome of patients undergoing re-irradiation (re-RT) for a recurrent or second primary head and neck cancer (RSPHNCs) in seven Italian tertiary centers, while testing Multi-Institution Reirradation (MIRI) recursive partitioning analysis (RPA) recently published.We retrospectively analyzed 159 patients. Prognostic factors overall survival (OS) selected by random forest model were included multivariable Cox analysis. externally validate MIRI RPA, we estimated...
After radical prostatectomy (RP) radiotherapy (RT) plays a role, both as adjuvant or salvage treatment. If negative features are present such extracapsular extension, seminal vesicle invasion, lymph and positive surgical margins, RT after RP reduces the risk of recurrence, although it is associated with an increased acute late toxicities. An intensified delivered in shortened time could improve clinical outcome be safely combined hormonal therapy (HT). The aim this study was to determine...
Conventionally fractionated chemoradiation (CRT) or chemotherapy (CHT) are considered as standard options in locally advanced pancreatic cancer (LAPC) while stereotactic body radiotherapy (SBRT) is an emerging treatment this setting. The aim of study was to compare two cohorts LAPC patients treated with SBRT ± CHT vs CRT terms local control (LC), distant metastases-free survival (DMFS), progression-free (PFS), overall (OS), and toxicity. Eighty were included. Patients the matched according...
Abstract Background Radiation therapy after lumpectomy is a standard part of breast conserving for invasive carcinoma. The most frequently used schedule worldwide 60 Gy in 30 fractions 6 weeks, time commitment that sporadically may dissuade some otherwise eligible women from undertaking treatment. purpose and primary endpoint this perspective study to evaluate feasibility short-term late toxicity hypofractionated whole irradiation schedule. Methods Between February October 2008 we treated 65...
Head and neck squamous cell carcinoma (HNSCC) has a poor clinical outcome despite the presence of rich CD8+ T tumor infiltrate in majority patients. This may be due to alterations infiltrating cells. Here, we performed characterization HNSCC cells cohort 30 The results showed that differential intratumoral frequency CD8+CD28+ cells, CD8+CD28− CD8+CD28−CD127−CD39+ Treg distinguished between patients who did or not respond treatment. Moreover, high PD1 expression identified subpopulation,...
The superior diagnostic accuracy of [68Ga]Ga-prostate-specific membrane antigen-11 (PSMA) ([68Ga]Ga-PSMA-11) compared to [18F]F-Fluorocholine Positron Emission Tomography/Computed Tomography (PET/CT) in Prostate Cancer (PCa) is established. However, it currently unclear if the added actually translates into improved clinical outcomes oligometastatic PCa patients treated with [68Ga]Ga-PSMA-11 PET-guided metastasis-directed therapy (MDT). present study aimed assess impact these two imaging...