A5003285966- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- Pancreatic and Hepatic Oncology Research
- Radiomics and Machine Learning in Medical Imaging
- Colorectal Cancer Treatments and Studies
- Advanced Radiotherapy Techniques
- Hepatocellular Carcinoma Treatment and Prognosis
- Prostate Cancer Treatment and Research
- Colorectal Cancer Screening and Detection
- Cancer Genomics and Diagnostics
- Prostate Cancer Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Radiopharmaceutical Chemistry and Applications
- Medical Imaging Techniques and Applications
- Lung Cancer Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Advanced X-ray and CT Imaging
- Cancer Treatment and Pharmacology
- Lung Cancer Research Studies
- Neutropenia and Cancer Infections
- MRI in cancer diagnosis
- Pancreatitis Pathology and Treatment
- Inhalation and Respiratory Drug Delivery
- Health Systems, Economic Evaluations, Quality of Life
- Gastrointestinal Tumor Research and Treatment
Azienda Ospedaliera Universitaria Pisana
2012-2023
University of Pisa
1997-2022
Ospedale Santa Chiara
2017
Maastricht University
2011
The purpose of this study was to develop accurate models and nomograms predict local recurrence, distant metastases, survival for patients with locally advanced rectal cancer treated long-course chemoradiotherapy (CRT) followed by surgery allow a selection who may benefit most from postoperative adjuvant chemotherapy close follow-up.All data (N = 2,795) five major European clinical trials were pooled used perform an extensive analysis multivariate based on Cox regression. Data one trial as...
A new entity of patients with recurrent prostate cancer limited to a small number active metastatic lesions is having growing interest: the oligometastatic patients. Patients disease could eventually be managed by treating all local therapy, i.e. either surgery or ablative stereotactic body radiotherapy. This study aims assess impact [(18)F]Choline ([(18)F]FMCH) PET/CT and use radiotherapy (SBRT) in (pts) (PCa).Twenty-nine pts PCa (≤3 synchronous detected [(18)F]FMCHPET/CT) were treated...
BackgroundTo retrospectively evaluate the difference in terms of pathologic complete response (pCR) according to time elapsed between chemoradiation (CRT) and total mesorectal excision (TME) on a large unselected real-life dataset locally advanced rectal cancer (LARC) patients.MethodsA multicentre retrospective cohort study LARC patients from 21 Italian Radiotherapy Institutions was performed. Patients were stratified into 3 different intervals CRT. The 1st group included 300 who underwent...
An observational multi-institutional study has been conducted aimed to evaluate the inter-observer variability in clinical target volume (CTV) delineation among different radiation oncologists radiotherapy treatment of pancreatic cancer. A contouring dummy-run two cases cancer treated by postoperative and preoperative (RT) was performed. Clinical history, diagnostics, planning CT imaging were available on AIRO website ( http://www.radioterapiaitalia.it ). Participants requested delineate...
The purpose of this study was to investigate the effect image preprocessing on radiomic features estimation from computed tomography (CT) imaging locally advanced rectal cancer (LARC). CT images 20 patients with LARC were used estimate 105 7 classes (shape, first-order, GLCM, GLDM, GLRLM, GLSZM, and NGTDM). Radiomic estimated for 6 different isotropic resampling voxel sizes, using 10 interpolation algorithms (at fixed bin width) widths algorithm). intraclass correlation coefficient (ICC)...
Aim: To assess the role of stereotactic body radiotherapy (SBRT) in pulmonary metastases from colorectal cancer (CRC). Patients and Methods: Thirty-three consecutive patients with CRC who received SBRT were included analysis. The primary endpoints local systemic progression-free survival, a secondary endpoint was safety profile SBRT. Results: A total 56 lesions treated single nodule 15 patients, two 13 three five. dose adopted fractionations 24-27 Gy as fraction for 40 27-42 fractions (2-3...
Abstract Background In the last years, functional imaging has given a significant contribution to clinical decision-making of biochemically relapsed prostate cancer (PCa). Hereby, we present prospective study aiming validate role [ 18 F]Fluoro-Methyl Choline ([ F]FMCH) PET/CT in selection PCa patients suitable for stereotactic body radiotherapy (SBRT). Methods Patients with biochemical recurrence limited up three lesions revealed by F]FMCH were enrolled and treated SBRT on all active...
Background/Aim: In the last years, use of Image Guided Stereotactic Radiotherapy (IG-SBRT) in patients with metastatic prostate cancer has increased. this study, we aimed to assess role IG-SBRT terms local control and safety cancer. Materials Methods: Primary secondary endpoints prospective observational study were related IG-SBRT. All lesions treated 24 Gy as a single fraction or 27 3 fractions. After SBRT, Systemic therapies administered only after occurrence more than three synchronous...
Tumor recurrence, a characteristic of malignant tumors, is the biggest concern for rectal cancer survivors. The epidemiology disease calls pressing need to improve healthcare quality and patient outcomes. Prediction models such as Bayesian networks, which can probabilistically reason under uncertainty, could assist caregivers with management. However, some concerns are associated standard approaches developing these structures in medicine. Therefore, this study aims compare network that stem...
Background: Due to the high soft tissue resolution, magnetic resonance imaging (MRI) could improve accuracy of pancreatic tumor delineation in radiation treatment planning. A multi-institutional study was proposed evaluate impact MRI on inter-observer agreement gross volume (GTV) and duodenum for cancer compared with computer tomography (CT).Material Methods: Two clinical cases borderline resectable (Case 1) unresectable 2) were selected. In two sequential steps, diagnostic contrast-enhanced...
4062 Background: FOLFIRINOX has shown high activity in metastatic pancreatic cancer (PC) patients and could be an interesting regimen also for with inoperable locally advanced disease. Our group had developed a similar schedule colorectal named FOLFOXIRI good tolerance activity. Therefore, we have decided to perform phase II trial prospectively evaluate the of modified borderline resectable or unresectable PC. Methods: Modified consisted lower dose irinotecan (150 mg/sqm) infusional...
Introduction The role of adjuvant chemoradiotherapy in patients with pancreatic adenocarcinoma (PA) is controversial. In this study we aimed to assess the feasibility, disease-free survival (DFS) and overall (OS) (gemcitabine based) resected PA their correlation prognostic factors. Methods 122 (stage ≥IIa) treated between February 1999 December 2013 were analyzed. Two cycles gemcitabine (1,000 mg/m 2 on days 1, 8 15 every 28 days) administered before concomitant radiotherapy (45 Gy/25...