A5061140559- Glioma Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Management of metastatic bone disease
- Advanced Radiotherapy Techniques
- Pituitary Gland Disorders and Treatments
- Endometrial and Cervical Cancer Treatments
- Childhood Cancer Survivors' Quality of Life
- Advanced X-ray and CT Imaging
- Radiopharmaceutical Chemistry and Applications
- Ovarian cancer diagnosis and treatment
- Brain Tumor Detection and Classification
- Sarcoma Diagnosis and Treatment
- Brain Metastases and Treatment
- Cancer Research and Treatments
- Neurogenesis and neuroplasticity mechanisms
- Medical Imaging Techniques and Applications
- Circular RNAs in diseases
- Renal and related cancers
- Renal cell carcinoma treatment
- Meningioma and schwannoma management
- Musculoskeletal synovial abnormalities and treatments
- Radiation Dose and Imaging
- Boron Compounds in Chemistry
- Immune cells in cancer
- Tendon Structure and Treatment
University of Genoa
2019-2024
Institut Gustave Roussy
2023-2024
Radiothérapie Moléculaire et Innovation Thérapeutique
2023-2024
Université Paris-Saclay
2023-2024
Inserm
2023-2024
Ospedale Policlinico San Martino
2019-2023
The superior diagnostic accuracy of [68Ga]Ga-prostate-specific membrane antigen-11 (PSMA) ([68Ga]Ga-PSMA-11) compared to [18F]F-Fluorocholine Positron Emission Tomography/Computed Tomography (PET/CT) in Prostate Cancer (PCa) is established. However, it currently unclear if the added actually translates into improved clinical outcomes oligometastatic PCa patients treated with [68Ga]Ga-PSMA-11 PET-guided metastasis-directed therapy (MDT). present study aimed assess impact these two imaging...
Tenosynovial giant cell tumour (TGCT) is a group of rare soft tissues neoplasia affecting synovial joints, bursae and tendon sheaths classified as localized type or diffuse type. The (TGCT-D), also known ‘pigmented villonodular (teno)synovitis’ characterized by local aggressivity, with invasion destruction adjacent soft-tissue structures, high recurrence rate. Radical surgery remains the standard therapy while adjuvant radiotherapy may help to control spread. Malignant TGCT rate recurrences...
The last version of the FIGO classification recommended imaging tools to complete clinical assessment patients with cervical cancer. However, preferable approach is still unclear. We aimed explore prognostic power Magnetic Resonance Imaging (MRI), contrast-enhanced Computed Tomography (ceCT), and [
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Abstract BACKGROUND Medulloblastoma 5-years survival rates range from 50-95% across risk classes, underscoring the need to mitigate treatment-related neurocognitive deficits. This study evaluates cognitive outcomes within 2 years post-radiotherapy, considering treatment modalities and various influencing factors. METHODS We conducted a retrospective monocentric on patients under 18 old, treated at our hospital 2007 2020, with histologically molecularly confirmed medulloblastoma, who...
Abstract BACKGROUND Pineal region tumors (PRT) account for 2.8% of all central nervous system in children and adolescents up to 19 years age. Modern therapies allow more than 2/3 patients overcome their disease, but late effects impair quality life survivors. This study aimed define the prevalence cognitive psychological PRT-survivors. METHODS Demographic information, medical variables, age-appropriated assessments childhood adolescence PRT-survivors, followed-up at Gaslini Children’s...
Aims: This study aims to evaluate the knowledge and referral practices regarding pediatric palliative radiotherapy (PRT) among Radiation Oncologists (ROs) Pediatric (POs) in Italy, focusing on identifying gaps, patterns, barriers optimal utilization of PRT oncology. Methods: A national survey, initiated by AIRO AIEOP, was conducted from September 2022 February 2023. Separate questionnaires for ROs POs were developed distributed, indications PRT, current practices, perceived barriers. The...
Abstract BACKGROUND Predicting progression-free survival (PFS) in glioblastoma (GB) is crucial for post-surgery treatment decisions. Detecting post-operative volumes via pre-radiotherapy (preRT) MRI, combined with clinical and molecular data, improves prognosis. A decision tree model using these features provides valuable insights into PFS when aligned the new RANO resection categories. MATERIAL AND METHODS We analyzed retrospective data from 205 GB treated by STUPP protocol across three...
Abstract BACKGROUND Several studies have highlighted the potential of assessing tissue vascularity in brain cancer management. However, conventional T2w-Dynamic Susceptibility Contrast (DSC) perfusion maps limited predictive power for relapse patterns grade 4 astrocytoma IDHm and glioblastoma. Newly proposed biomarkers offer deeper insights into hemodynamic parameters. In this study, we evaluated ability these to predict active tumor regions at based on standard pre-radiotherapy (preRT)...
Introduction The aim of this work was to explore the use an original once-weekly radiotherapy fractionation in elderly or frail patients with recurrence metastasis from different solid malignancies.
Abstract BACKGROUND High-grade gliomas are the most common type of primary brain tumor in adult patients. Despite a multimodal treatment, prognosis remains poor. Accurate stratification survival is crucial for choosing best course therapy. The objective this study was to use radiomics analysis based on multiparametric MRI combined with clinical data high-grade patients incomplete resection identify predictive signature according their overall survival. MATERIAL AND METHODS In multicentric...
Three-dimensional conformal RT (3D-RT) techniques are gold standard for post-operative flank radiotherapy (RT) in paediatric renal tumours. Recently, highly (HC-RT) have been implemented without comparative clinical data. The main objective of this multicentre study was to compare locoregional control (LRC) children treated either with HC-RT or 3D-RT techniques.Patients tumour registered the national cohort PediaRT between March 2013 and September 2019 were included. Treatment follow-up...
Abstract BACKGROUND The integration of molecular data and histology changed the diagnostic approach prognostic characterization for patients with brain tumors. aim this study is identify risk factors associated seizure occurrence and/or recurrence after surgery in glioblastoma. MATERIAL AND METHODS Patients glioblastoma were consecutively enrolled underwent surgery, followed by histopathological evaluation. Immuno-histochemical, (synaptophysin, GFAP, ATRX, p53, ki67 index MGMT gene promoter...
Abstract BACKGROUND The aim of our multi-centric study is to evaluate the predictive relapse factors for high-grade glioma patients. MATERIAL AND METHODS We studied retrospectively cohort patients, from 2009 2021 at three French medical centers. This data collection was carried out as part national funding promote integration AI tools into clinical oncology routine (AI.DReAM project). Clinical, pathological, genomic, and radiotherapy data, with MR images before treatment relapse, were...