A5080840934- Cancer Immunotherapy and Biomarkers
- Renal cell carcinoma treatment
- Cancer Genomics and Diagnostics
- Prostate Cancer Treatment and Research
- Bladder and Urothelial Cancer Treatments
- Genetic factors in colorectal cancer
- Colorectal Cancer Treatments and Studies
- Economic and Financial Impacts of Cancer
- Pancreatic and Hepatic Oncology Research
- Brucella: diagnosis, epidemiology, treatment
- BRCA gene mutations in cancer
- Cancer, Lipids, and Metabolism
- Urinary and Genital Oncology Studies
- Inflammatory Biomarkers in Disease Prognosis
- Ferroptosis and cancer prognosis
- Helicobacter pylori-related gastroenterology studies
- DNA Repair Mechanisms
- Radiopharmaceutical Chemistry and Applications
- Tendon Structure and Treatment
- Nonmelanoma Skin Cancer Studies
- Peripheral Nerve Disorders
- Nail Diseases and Treatments
- Colorectal and Anal Carcinomas
- Sarcoma Diagnosis and Treatment
- T-cell and Retrovirus Studies
Ospedale Policlinico San Martino
2019-2024
University of Genoa
2022-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2024
University of Messina
2011-2020
University of Catania
1992-2019
CTO Hospital
2013
Radium-223 dichloride (Ra223) represents the unique bone-directed treatment option that shows an improvement in overall survival (OS) metastatic castrate resistant prostate cancer (mCRPC). However, there is urgent need for identification of reliable biomarkers to non-invasively determine its efficacy (possibly improving patients’ selection or identifying responders’ after therapy completion). 18F-Fluorodeoxyglucose (FDG)-avidity low naïve cancer, but it enhanced advanced and...
Importance Low sodium levels have been associated with negative outcomes among patients metastatic renal cell carcinoma (mRCC) receiving therapies other than immune checkpoint inhibitors (ICIs). Objective To investigate the role of natremia in mRCC nivolumab as a second-line or subsequent therapy. Design, Setting, and Participants In this retrospective cohort study, clinical biochemical data were collected from October 2015 to November 2019 part multicenter Italian study. Data analysis was...
Over the last years has emerged urgent need for identification of reliable prognostic biomarkers able to potentially identify metastatic castration-resistant prostate cancer (mCRPC) patients most likely benefit from Radium-223 (Ra-223) since baseline. In present monocentric retrospective study, we analyzed power systemic inflammation and 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography (FDG-PET)-derived parameters their potential interplay in this clinical setting. The...
Inflammatory myofibroblastic tumor (IMT) is a very rare subtype of sarcoma, which frequently harbor chromosomal rearrangements, including anaplastic lymphoma kinase (ALK) rearrangements (almost 50% the IMTs) and other fusions such as ROS1. ROS1 are present in about 10% IMT, almost half ALK-negative IMT patients. Apart from radical surgery for resectable tumors, there no standard-of-care therapy advanced IMTs. Nonetheless, use tyrosine inhibitors has shown promising efficacy patients with...
Apalutamide is an oral selective androgen receptor inhibitor, approved by the FDA for treatment of patients with non-metastatic, castration-resistant prostate cancer (M0 CRPC) at high risk developing metastases and metastatic castration-sensitive (mHSPC) in association deprivation therapy (ADT). In registration studies, skin reactions were reported among most common side effects as adverse event special interest.Apalutamide-induced rash includes a wide spectrum different types reactions, but...
Multigene germline panel testing is recommended for Pancreatic Cancer (PC) patients; however, non-BRCA1/2 genes, the clinical utility unclear. A comprehensive multi-gene assessment in unselected Italian PC patients missing. We evaluated prevalence and impact of Pathogenic Variants (PV) 51 susceptibility genes a real-world series 422 Family History (FH), compared characteristics conducted survival analyses. 17% had PVs (70/422), mainly BRCA1/2 (4.5%, all <70 y), CDKN2A >50 ATM (2.1%). PV...
Wound dehiscence is a surgical complication caused by the application of opposing and distracting forces tending to pull apart suture line. In recent years, novel negative pressure management system has been developed prevent wound complications. This creates closed environment that removes exudates other potentially infectious material, protects site from external contamination, provides support in holding edges incision together promotes healing. this study, we describe our first...
Immunotherapies exhibit peculiar cancer response patterns in contrast to chemotherapy and targeted therapy. Some patients experience disease after initial progression or durable responses treatment interruption. In clinical practice, immune checkpoint inhibitors may be continued radiological if benefit is observed. As a result, estimating progression-free survival (PFS) based on the first not accurately reflect actual of immunotherapy.
Background Human chorionic gonadotropin (hCG)–induced hyperthyroidism is a rare paraneoplastic syndrome observed in non-seminomatous testicular germ cell tumors, due to cross-reaction between the β-subunit of hCG with thyroid-stimulating hormone receptor. The precise prevalence this phenomenon unclear as, majority cases, remains subclinical. Case presentation Here, we present two cases advanced metastatic tumors where patients exhibited signs and symptoms thyrotoxicosis at primary diagnosis...
Anemia, mean corpuscular volume and red cell distribution width may have some effects on survival outcomes of metastatic renal carcinoma (mRCC) patients are incorporated in a blood (RBC)-based score. Its validity prognostication mRCC treated with second-line nivolumab was assessed.
Prognostic and predictive factors for patients with metastatic renal cell carcinoma (mRCC) treated immunotherapy are highly warranted, the immune tumor microenvironment (I-TME) is under investigation.The Meet-URO 18 was a multicentric retrospective study assessing I-TME in mRCC ≥2nd-line nivolumab, dichotomized into responders non-responders according to progression-free survival (≥12 months ≤3 months, respectively). The primary objective identify differential immunohistochemical (IHC)...
Tenosynovial giant cell tumour (TGCT) is a group of rare soft tissues neoplasia affecting synovial joints, bursae and tendon sheaths classified as localized type or diffuse type. The (TGCT-D), also known ‘pigmented villonodular (teno)synovitis’ characterized by local aggressivity, with invasion destruction adjacent soft-tissue structures, high recurrence rate. Radical surgery remains the standard therapy while adjuvant radiotherapy may help to control spread. Malignant TGCT rate recurrences...
Emerging evidence highlights the potential prognostic relevance of circulating lipids in metastatic castration-resistant prostate cancer (mCRPC), with a proposed 3-lipid signature. This study aims to analyze lipidomic profiles individuals mCRPC identify lipid species that could serve as predictive indicators prognosis and therapeutic response. Plasma samples were collected from patients initiating first-line treatment (1 L) (n = 29) those previously treated at least two lines therapy (> 2...