A5021647356- Pituitary Gland Disorders and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Neuroendocrine Tumor Research Advances
- Adrenal and Paraganglionic Tumors
- Ophthalmology and Eye Disorders
- Neuroblastoma Research and Treatments
- Sexual Differentiation and Disorders
- Hormonal and reproductive studies
- Gestational Trophoblastic Disease Studies
- Adrenal Hormones and Disorders
- Testicular diseases and treatments
- Sexual function and dysfunction studies
- Genomics and Rare Diseases
- Cancer Treatment and Pharmacology
- Biomedical Text Mining and Ontologies
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Glioma Diagnosis and Treatment
Ospedale Policlinico San Martino
2016-2025
University of Genoa
2013-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2024
University of Catania
2012
Background Immune checkpoint inhibitors (ICIs) have revolutionised the cancer treatment landscape in last decades, improving outcome of several tumours, such as cutaneous squamous cell carcinoma (cSCC). ICIs are antibodies blocking immune pathways, cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and programmed death 1 (PD-1) with its ligand PD-L1. However, activation response can cause a broad range side effects, called immune-related adverse events (irAEs). Endocrine irAEs mainly...
Background First-generation somatostatin receptor ligands (fg-SRLs) represent the first-line medical treatment for acromegaly, recommended in patients with persistent disease after neurosurgery, or when surgical approach is not feasible. Despite lack of strong recommendations from guidelines and consensus statements, data national Registries report an increasing use therapy as acromegaly. Objective We retrospectively evaluated potential role a large number clinical radiological parameters...
Abstract Context Discordant growth hormone (GH) and insulin-like factor-1 (IGF-1) values are frequent in acromegaly. Objective To evaluate the impact of different GH cutoffs on discordance rate. investigate whether mean consecutive measurements impacts rate when matched to last available IGF-1 value. Design Retrospective study. Setting Referral center for pituitary diseases. Patients Ninety acromegaly patients with at least 3 evaluations using same assay laboratory (median follow-up 13...
Background Human chorionic gonadotropin (hCG)–induced hyperthyroidism is a rare paraneoplastic syndrome observed in non-seminomatous testicular germ cell tumors, due to cross-reaction between the β-subunit of hCG with thyroid-stimulating hormone receptor. The precise prevalence this phenomenon unclear as, majority cases, remains subclinical. Case presentation Here, we present two cases advanced metastatic tumors where patients exhibited signs and symptoms thyrotoxicosis at primary diagnosis...
Abstract Background The vanishing testis syndrome (VTS), is a 46, XY disorder of sex development (46, DSD) and characterized by the absence in subject with male genitalia, gonadal dysgenesis consequent hypergonadotropic hypogonadism. Case presentation A young man affected VTS has been followed up for more than 15-year our center. patient received different testosterone formulations, which modulated his IGF-1 levels height velocity, depending on stimulatory effects, mimicking pubertal spurt...
Summary The resistance to thyroid hormone syndrome (RTHβ) occurs uncommonly and requires a high level of clinical suspicion specific investigations reach precise diagnosis avoid unnecessary potentially harmful therapies. We report case young male patient referred our unit for SARS-CoV-2 infection atrial fibrillation with elevated hormones non-suppressed thyroid-stimulating (TSH), which antithyroid therapy was prescribed. A mood disorder reported in the medical history. family history unknown...
Undiagnosed rare diseases include with a well-characterised phenotype, unknown molecular causes or due to non-genetic factors, and pathological condition that cannot be named. Several initiatives have been launched for healthcare of patients undiagnosed diseases. A project development medical records special reference the HL7 standards is being carried out in Genoa (Italy), taking into account regional national regulations. The based on integration functionality related patient diagnostics,...
Altomare, Maria; Vicari, Lucia O.; Ferrante, Margherita; Fiore, Sciacca, Salvatore; Condorelli, Rosita A.; La Vignera, Sandro; Cocchiara, Francesco; Calogero, Aldo E.; Enzo Author Information
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)