A5018312644- Hormonal and reproductive studies
- Sexual Differentiation and Disorders
- Ovarian function and disorders
- Pharmacology and Obesity Treatment
- Thyroid Disorders and Treatments
- Neuroendocrine regulation and behavior
- Sperm and Testicular Function
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Muscle metabolism and nutrition
- Sexual function and dysfunction studies
- Estrogen and related hormone effects
- Hormonal Regulation and Hypertension
- Stress Responses and Cortisol
- Thyroid Cancer Diagnosis and Treatment
- Neuroscience of respiration and sleep
- Growth Hormone and Insulin-like Growth Factors
- Hypothalamic control of reproductive hormones
- Diabetes Treatment and Management
- COVID-19 Clinical Research Studies
- Vitamin D Research Studies
- Diabetes and associated disorders
- Metabolism, Diabetes, and Cancer
- Adrenal Hormones and Disorders
- Reproductive Biology and Fertility
- Pharmacological Effects and Assays
University of Bari Aldo Moro
2015-2024
Ospedale Pediatrico Giovanni XXIII
2024
Santa Maria Nuova Hospital
2022-2023
Gastroenterology Hospital "Saverio de Bellis"
2022
Novartis (Italy)
2022
Ospedale A. Perrino
2021
Presidio Ospedaliero
2012
Ospedale Santa Maria
1999
Ghent University Hospital
1988-1996
Several aspects of the regulation androgen secretion and plasma levels in males remain controversial. Among these, we cite problem whether age-related decrease testosterone (T) is an intrinsic aging phenomenon or a sequel previous illness, mechanisms underlying increase sex hormone-binding globulin (SHBG)-binding capacity men supranormal observed immediately after weight-reducing diet, role insulin age-associated dehydroepiandrosterone (sulfate) [DHEA (DHEAS)] levels. To gain further insight...
Current diagnostic criteria for polycystic ovary syndrome (PCOS) have generated distinct PCOS phenotypes, based on the different combinations of features found in each patient. Our aim was to assess whether either single feature or their into phenotypes may predict insulin resistance these women.A total 137 consecutive Caucasian women with PCOS, diagnosed by Rotterdam criteria, underwent accurate assessment and metabolic features. Insulin sensitivity measured glucose clamp technique.Among...
Sarcopenia is an age-related clinical complaint characterized by the progressive deterioration of skeletal muscle mass and strength over time. Type 2 diabetes (T2D) associated with faster more relevant impairment. Both conditions influence each other, leading to negative consequences on glycemic control, cardiovascular risk, general health status, risk falls, frailty, overall quality life, mortality. PubMed/Medline, Scopus, Web Science, Google Scholar were searched for research articles,...
In obese men, sex hormone-binding globulin levels (SHBG) as well total plasma testosterone (T) are decreased. Data concerning the of nonprotein-bound (FT) discordant, with some researchers reporting normal levels, and other decreased levels. The latter imply an impairment feedback regulation mechanism FT We investigated whether eventual decrease in and, hence, functional gonadostat might occur only at a more severe degree obesity than that required for SHBG T We, therefore, determined...
Cushing's syndrome may remain unrecognized among patients referred for metabolic syndrome; thus, a proactive screening has been suggested in certain patient populations with features of the disorder. However, conflicting data have reported on prevalence type 2 diabetes.Our aim was to evaluate unsuspected outpatients diabetes.This cross-sectional prospective study 24 diabetes clinics across Italy.Between June 2006 and April 2008, 813 known without clinically overt hypercortisolism were...
Summary The aim of this retrospective observational study was to evaluate whether adding liraglutide lifestyle changes, metformin (Met) and testosterone replacement therapy (TRT), by means improving weight glycaemic control, could boost erectile function in type 2 diabetic obese men with overt hypogonadism dysfunction (ED) a ‘real‐life setting’. Forty‐three obese, hypogonadal (aged 45–59 years) were evaluated because complaining about the recent onset ED. They subdivided into two groups...
Abstract The objective of this study was to estimate the minimum in vivo effective oral dose and duration action competitive 5α‐reductase inhibitor MK‐906, a 4‐azasteroid, humans. Plasma dihydrotestosterone (DHT), 5α‐androstane‐3α, 17β‐diol (AD), its glucuronide (ADG), as well urinary androsterone (A) 5α‐pregnane‐3α, 11β, 17α, 21‐tetrol‐20‐one (aH 4 F) were determined 54 healthy young men before up 7 days after single morning compound. Twenty‐four hours 5‐to 40‐mg (n = 24), plasma DHT levels...
Hyperandrogenism is a common feature of women with polycystic ovary syndrome (PCOS) and considered cardinal element for the diagnosis phenotyping this condition. Unfortunately, routinely available methods measuring serum androgens suffer from major limitations. No data are on impact androgen assay quality assignment PCOS to different clinical phenotypes PCOS, when defined according Rotterdam criteria diagnosis.Two hundred four consecutive Caucasian diagnosed by participated in...
Abstract Background Functional hypogonadism is a common disorder among patients with obesity and type 2 diabetes mellitus could be managed by first treating the underlying causes. Objective The present study was undertaken to investigate contribution of body weight glycemic control reversibility eugonadism in real‐life setting. Materials methods Adult obese male uncontrolled mellitus, complaining mild moderate erectile dysfunction suspected functional evaluated at our institution from 2015...