A5082779954- Bone health and osteoporosis research
- Hormonal and reproductive studies
- Bone health and treatments
- Sexual Differentiation and Disorders
- Hypothalamic control of reproductive hormones
- Vitamin D Research Studies
- Ovarian function and disorders
- Growth Hormone and Insulin-like Growth Factors
- Stress Responses and Cortisol
- Bone Metabolism and Diseases
- Muscle metabolism and nutrition
- Nutrition and Health in Aging
- Thyroid Disorders and Treatments
- Hip and Femur Fractures
- Estrogen and related hormone effects
- Body Composition Measurement Techniques
- Pharmacological Effects and Assays
- LGBTQ Health, Identity, and Policy
- Bone and Joint Diseases
- Pharmacology and Obesity Treatment
- Regulation of Appetite and Obesity
- Hormonal Regulation and Hypertension
- Sperm and Testicular Function
- Adipose Tissue and Metabolism
- Frailty in Older Adults
Ghent University Hospital
2016-2025
Ghent University
2010-2022
United States Congress
2022
Universitair Ziekenhuis Brussel
1997-2020
KU Leuven
2018
University of Liège
1987-2017
AZ Sint-Lucas
2016
University of Verona
2016
Universidad de Zaragoza
2015
GTx (United States)
2006-2015
Abstract The free and nonspecifically bound plasma hormone levels generally reflect the clinical situation more accurately than total levels. Hence, it is important to have reliable indexes of these fractions. apparent testosterone (T) concentration obtained by equilibrium dialysis (AFTC) as well fraction serum T not precipitated 50% ammonium sulfate (non-SHBG-T; SHBG, sex hormone-binding globulin), often referred bioavailable T, appear represent biologically readily available but are suited...
Bisphosphonates are effective agents for the management of osteoporosis. Their low bioavailability and potency necessitate frequent administration on an empty stomach, which may reduce compliance. Gastrointestinal intolerance limits maximal dosing. Although intermittent intravenous treatments have been used, optimal doses dosing interval not systematically explored.
Demographic data clearly demonstrate that the percentage of population in older age group is increasing. Androgen deficiency aging male has become a topic increasing interest and debate throughout world. Cross-sectional longitudinal indicate testosterone falls progressively with significant men over 60 years have serum levels are below lower limits young adult (age 20–30 years) (1–4). The principal questions raised by these observations whether hypogonadal will benefit from treatment what be...
Abstract Background All proposed definitions of sarcopenia include the measurement muscle mass, but techniques and threshold values used vary. Indeed, literature does not establish consensus on best technique for measuring lean body mass. Thus, objective is hampered by limitations intrinsic to assessment tools. The aim this study was review methods assess mass reach development a reference standard. Methods Literature reviews were performed members European Society Clinical Economic Aspects...
Comprehensive proteomic profiling of the human adipocyte secretome identified dipeptidyl peptidase 4 (DPP4) as a novel adipokine. This study assessed functional implications adipokine DPP4 and its association to metabolic syndrome.Human adipocytes skeletal smooth muscle cells were used monitor release assess effects soluble on insulin signaling. In lean obese subjects, depot-specific expression from adipose tissue explants determined correlated parameters syndrome.Fully differentiated...
To evaluate the continued efficacy and safety of alendronate (ALN) for up to 2 years in patients receiving glucocorticoids.This is a 12-month extension previously completed 1-year trial daily ALN, performed effects ALN over total 66 men 142 women continuing receive at least 7.5 mg prednisone or equivalent daily. All received supplemental calcium vitamin D. The primary end point was mean percentage change lumbar spine bone mineral density (BMD) from baseline 24 months. Other outcomes included...
Several aspects of the regulation androgen secretion and plasma levels in males remain controversial. Among these, we cite problem whether age-related decrease testosterone (T) is an intrinsic aging phenomenon or a sequel previous illness, mechanisms underlying increase sex hormone-binding globulin (SHBG)-binding capacity men supranormal observed immediately after weight-reducing diet, role insulin age-associated dehydroepiandrosterone (sulfate) [DHEA (DHEAS)] levels. To gain further insight...
The role of estrogens in male physiology has become more evident, as a consequence the discovery human models estrogen deficiency such resistance or aromatase deficiency. In males, testosterone is major source plasma estradiol, main biologically active estrogen, only 20% which secreted by testes. Plasma estrone, 5% converted to originates from tissue aromatization of, mainly adrenal, androstenedione. concentration estradiol males 2-3 ng/dl and its production rate blood 25-40 micrograms/24 h;...
Demographic data clearly demonstrate that the percentage of population in older age group is increasing. Androgen deficiency aging male has become a topic increasing interest and debate throughout world. Cross-sectional longitudinal indicate testosterone falls progressively with significant men over 60 years have serum levels are below lower limits young adult (age, 20–30 years) (Gray et al, 1991; Harman 2001; Araujo 2007; Wu 2008). The principal questions raised by these observations...
Fractures in men are a major health issue, and data on the antifracture efficacy of therapies for osteoporosis limited. We studied effect zoledronic acid fracture risk among with osteoporosis.
Background:Vitamin D insufficiency has deleterious consequences on health outcomes. In elderly or postmenopausal women, it may exacerbate osteoporosis.
Objective This study evaluated the short- and long-term cardiovascular- cancer-related morbidities during cross-sex hormone therapy in a large sample of trans persons. Subjects methods A specialist center cross-sectional compared 214 women (male-to-female transsexual persons) 138 men (female-to-male with an age- gender-matched control population (1–3 matching). The participants were on for average 7.4 years. We assessed physical health possible treatment-related adverse events using...
Reference ranges for testosterone are essential making a diagnosis of hypogonadism in men. To establish harmonized reference total men that can be applied across laboratories by cross-calibrating assays to method and standard. The 9054 community-dwelling cohort studies the United States Europe: Framingham Heart Study; European Male Aging Osteoporotic Fractures Men Sibling Study Osteoporosis. Testosterone concentrations 100 participants each four cohorts were measured using at Centers Disease...