A5024776789- Thyroid Cancer Diagnosis and Treatment
- Thyroid and Parathyroid Surgery
- Pituitary Gland Disorders and Treatments
- Migraine and Headache Studies
- Adrenal and Paraganglionic Tumors
- Head and Neck Anomalies
- Hormonal Regulation and Hypertension
- Stress Responses and Cortisol
- Adrenal Hormones and Disorders
- Thyroid Disorders and Treatments
- Hormonal and reproductive studies
- Sympathectomy and Hyperhidrosis Treatments
- Ophthalmology and Eye Disorders
- Neuroendocrine Tumor Research Advances
- Radiomics and Machine Learning in Medical Imaging
- Neurological Disorders and Treatments
- Diet and metabolism studies
- Neuropeptides and Animal Physiology
- Growth Hormone and Insulin-like Growth Factors
- Regulation of Appetite and Obesity
- Hypothalamic control of reproductive hormones
- Ultrasound and Hyperthermia Applications
- Receptor Mechanisms and Signaling
- Genetic factors in colorectal cancer
- Trigeminal Neuralgia and Treatments
A. O. Ordine Mauriziano di Torino
2012-2022
Advanced Micro Devices (Canada)
2021
University of Turin
1995-2018
Policlinico Umberto I
2015-2017
Presidio Ospedaliero
2010-2012
Torino e-district
2010
Background: Percutaneous radiofrequency thermal ablation (RTA) is a promising new therapeutic approach to manage thyroid nodules (TNs). The aim of this study was investigate the long-term effectiveness RTA in inducing shrinkage TNs as well controlling compressive symptoms and hyperfunction large series elderly subjects with solid or mainly benign TNs. Methods: Ninety-four patients cytologically were prospectively enrolled study; 66 them had nontoxic goiter 28 toxic pretoxic goiter. performed...
Summary Background Fine‐needle aspiration biopsy (FNAB) is the primary means to distinguish benign from malignant nodules and select patients for surgery. However, adjunctive diagnostic tests are needed because in 20–40% of cases FNAB result uncertain. Objective We investigated whether a search oncogenes RET/PTC , TRK BRAF V600E thyroid aspirates could refine an uncertain diagnosis. Patients methods A total 132 aspirates, including colloid nodules, inadequate samplings, indeterminate...
Background: Percutaneous radiofrequency thermal ablation (RFA) has been reported as an effective tool for the management of benign thyroid nodules (BTN). However, large, randomized controlled trials (RCTs) are lacking. Objective: The aims this study were to assess volume reduction BTN after a single RFA performed using moving-shot technique and compare obtained in patients treated two centers with different experience technique. Method: This was international prospective RCT. It carried out...
Objective Isolated hypogonadotropic hypogonadism (IHH) is a rare disorder with pubertal delay, normal (normoosmic-IHH, nIHH) or defective sense of smell (Kallmann syndrome, KS). Other reproductive and non-reproductive anomalies might be present although information on their frequency are scanty, particularly according to the age presentation. Design Observational cohort study carried out between January 2008 June 2016 within national network academic general hospitals. Methods We performed...
Background The purpose of this study was to confirm the generalisation radiofrequency ablation (RFA) in treatment benign thyroid nodules (BTN) and look for a correlation between final shrinkage some ultrasound (US) findings large Italian population data set. Methods This prospective included 337 patients with solid cold BTN from six institutions. Nodule volume, US pattern, function, symptom/cosmetic scores complications were evaluated before at 6 12 months. primary outcome find basal volume...
Cushing's syndrome may remain unrecognized among patients referred for metabolic syndrome; thus, a proactive screening has been suggested in certain patient populations with features of the disorder. However, conflicting data have reported on prevalence type 2 diabetes.Our aim was to evaluate unsuspected outpatients diabetes.This cross-sectional prospective study 24 diabetes clinics across Italy.Between June 2006 and April 2008, 813 known without clinically overt hypercortisolism were...
Objectives: The goal of evidence-based practice guidelines is to optimize the management emerging diseases, such as differentiated thyroid cancer (DTC). aim this study was assess therapeutic approaches for DTC in Italy and see how closely these practices conformed those recommended 2009 American Thyroid Association (ATA) guidelines. Methods: Italian Cancer Observatory established collect data prospectively on cancers consecutively diagnosed participating centers (uniformly distributed across...
Aldosterone suppression by dexamethasone, and high 18-hydroxycortisol 18-oxocortisol levels are used to differentiate glucocorticoid-remediable aldosteronism (GRA) from other forms of primary aldosteronism. These methods time consuming, expensive, impractical for large studies. Moreover, diagnosis GRA requires a confirmatory genetic test. We evaluated 117 patients with referred our centers the use long PCR technique reveal chimeric gene GRA. In 60 patients, response aldosterone dexamethasone...
Several studies have shown the presence of a comorbidity between migraine and vascular diseases, like hypertension stroke. The mechanisms this are unknown. Impaired insulin sensitivity has recently emerged as risk factor for We evaluated in 30 young, nonobese, nondiabetic, normotensive patients 15 healthy controls. During OGTT, glucose plasma concentrations were significantly higher migraineurs than Insulin sensitivity, measured by ISI-stumvoll OGIS-180 indexes, was altered migraine. Our...
Ten to fifteen percent of fine-needle aspiration biopsy (FNAB) thyroid nodules are indeterminate. Galectin-3 (Gal-3) and the oncogene BRAFV600E markers malignancy useful improve FNAB accuracy. The objective this study was determine whether combined analysis Gal-3 expression in aspirates could diagnosis with suspicious cytological findings. Two hundred sixty-one surgical tissues one forty-four were analyzed for presence two markers. In specimens, present 27.4% benign nodules, 91.9% papillary...
Fine-needle aspiration cytology (FNAC) is the primary means to distinguish benign thyroid nodules from malignant ones. About 20% of FNAC yields indeterminate results leading unnecessary or delayed surgery. Many studies tissue samples, majority which are retrospective advocate testing for RET rearrangements as a diagnostic adjunctive tool in with cytological findings. Because uncertain prevalence rearrangements, its utility tumor marker still controversial. The goal this study was establish...
Benign thyroid nodules display a broad range of behaviors from stationary size to progressive growth. The RET/PTC oncogene has been documented in fraction benign nodules, besides papillary carcinomas, and it might therefore influence their growth.The aim the present work was evaluate whether associates with different nodular growth rate.In this prospective multicentric study, 125 subjects were included. RET rearrangements analyzed cytology samples; clinical ultrasonographic nodule...
Biglino A, Limone P, Forno B, Pollono Cariti G, Molinatti GM, Gioannini P. Altered adrenocorticotropin and cortisol response to corticotropin-releasing hormone in HIV-I infection. Eur J Endocrinol 1995;133:173-9. ISSN 0804-4643 Alterations of the hypothalamic-pituitary-adrenal (HPA) axis are common HIV To characterize further site these derangements their possible causes, eight male drug addicts with symptomatic infection (stage IV C2) underwent following investigations: repeated baseline...
Fine-needle aspiration cytology (FNAC) has proved to be an effective diagnostic tool in patients with thyroid nodules. Several reporting schemes have been suggested define the risk of malignancy and consequent clinical management. To date, however, among lesions showing a follicular pattern, FNAC is still unable differentiate between benign malignant ones. The aim our study was evaluate whether subclassification cytologic specimens, based on cytoarchitectural patterns, could categories...
Recent studies suggested a potential association between both overt and subclinical hypothyroidism migraine. Aims of this study were to estimate the comorbidity migraine in patients with evaluate associated clinical characteristics.Using case-control strategy, 151 consecutive (mean age 48.36 ± 15.86 years) 150 controls 50.86 9.19 recruited. In all subjects, characteristics collected through direct interview. Clinical biochemical parameters (thyroid-stimulating hormone, free triiodothyronine,...
Anaplastic thyroid cancer (ATC) has a median survival less than 5 months and, to date, no effective therapy exists. Taxanes have recently been stated as the main drug treatment for ATC, and histone deacetylase inhibitor valproic acid efficiently potentiates effects of paclitaxel in vitro. Based on these data, this trial assessed efficacy safety combination ATC. This was randomized, controlled phase II/III trial, performed 25 ATC patients across centers northwest Italy. The experimental arm...