A5011653848- Hormonal and reproductive studies
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Sexual Differentiation and Disorders
- Sperm and Testicular Function
- Sexual function and dysfunction studies
- Pituitary Gland Disorders and Treatments
- COVID-19 Clinical Research Studies
- Ovarian function and disorders
- Adrenal and Paraganglionic Tumors
- Hypothalamic control of reproductive hormones
- Growth Hormone and Insulin-like Growth Factors
- Thyroid Disorders and Treatments
- Ovarian cancer diagnosis and treatment
- Stress Responses and Cortisol
- Estrogen and related hormone effects
- Long-Term Effects of COVID-19
- Sexuality, Behavior, and Technology
- Pharmacology and Obesity Treatment
- Bone health and osteoporosis research
- Genetic Neurodegenerative Diseases
- Testicular diseases and treatments
- Reproductive Biology and Fertility
- Muscle metabolism and nutrition
- Vitamin D Research Studies
- Dermatological and COVID-19 studies
IRCCS Humanitas Research Hospital
2015-2025
Istituti di Ricovero e Cura a Carattere Scientifico
1998-2023
Humanitas University
2006-2023
Fondazione Humanitas per la Ricerca
1998-2019
University of Milan
1997-2000
IRCCS Istituto Auxologico Italiano
1998
Ospedale Maggiore
1998
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
1998
Background: Ultrasound (US)–elastography is a newly developed imaging technique for the reconstruction of tissue stiffness by measuring degree tissue's deformation in response to application an external force. This has previously been shown be useful differential diagnosis between benign and malignant tumors. Methods: The objective this study was assess diagnostic accuracy US-elastography thyroid cancer, using cytologic/histopathologic analysis as reference standard. A total 67 consecutive...
Objective Isolated hypogonadotropic hypogonadism (IHH) is a rare disorder with pubertal delay, normal (normoosmic-IHH, nIHH) or defective sense of smell (Kallmann syndrome, KS). Other reproductive and non-reproductive anomalies might be present although information on their frequency are scanty, particularly according to the age presentation. Design Observational cohort study carried out between January 2008 June 2016 within national network academic general hospitals. Methods We performed...
ABSTRACT: The pathogenesis of delayed ejaculation (DE) is rather unknown, though the contribution various psychological, marital, hormonal, and neurological factors has been advocated. In this study we systematically investigated relative relevance aforementioned in 1632 men who were seeking medical help for sexual dysfunction. severity DE was classified according to Kaplan criteria. Mild moderate forms (MMDE) recognized different risk than most severe ones (anejaculation or [ASDE]). ASDE...
OBJECTIVE We have investigated the prevalence of MEN 1 in patients with recognized pituitary adenomas. Since hyperparathyroidism is present nearly 95–100% and frequently first condition to be identified, study was limited identification while screening for gastroenteropancreatic (GEP) lesions carried out both parathyroid lesions. PATIENTS AND MEASUREMENTS Serum total ionized calcium, phosphate intact PTH 1‐84 (EASIA) were measured 166 (68 non‐functioning adenoma, 42 prolactinoma, 35...
Variations in asparagine-linked carbohydrate chains have a major impact on TSH biological properties. In particular, highly sialylated is characterized by impaired intrinsic bioactivity and prolonged half-life. The aim of the present study was to investigate changes degree sialylation circulating isoforms that may occur several physiological clinical situations. Bioactivity terminal sugar residues immunopurified were studied 26 normal adults (day- nighttime serum pools), 2 cord pools from...
Fall in total testosterone (tT) levels Klinefelter syndrome (KS) may occur at different times of sexual development, although overt hypogonadism generally occurs after puberty. Nevertheless, it is still debated whether patients with KS are exposed to normal androgen during fetal life. Anogenital distance (AGD) an anthropometric measure reflecting androgenization the period. A shorter AGD men was associated infertility, genital anomalies, and testicular cancer. Although other...
It is known that either chronic glucocorticoid administration or endogenous hypercortisolism frequently induce an hypercoagulable condition. Since little about the evaluation of markers haemostatic and fibrinolytic systems in other adrenal disorders, we studied plasminogen activator inhibitor (PAI-1), tissue-plasminogen (t-PA), fibrinogen von Willebrand factor antigen (vWF-Ag) levels 11 patients with Cushing's syndrome 12 incidentaloma. In mean PAI-1, t-PA vWF-Ag did not significantly differ...
Abstract Background Hypogonadism occurs in myotonic dystrophies type 1 ( MD 1) and 2 2). Sertoli Leydig cell secretions, including insulin‐like peptide‐3 INSL 3), anti‐Müllerian hormone AMH ) inhibin B, were evaluated male patients with . Design Academic settings. Forty‐four [31 1, 13 2, aged 59 (50–64) years, median (interquartile range)], age‐, sex‐ BMI ‐matched non‐ hypogonadal n = 14) healthy controls 32). Serum FSH , LH testosterone (T) 3 measured; fat muscle masses by DEXA Results...
Klinefelter syndrome (KS) may induce skeletal fragility, but the studies so far published on this topic were mainly focused evaluation of bone mineral density (BMD) and microstructure, whereas data fracture risk are still lacking.To evaluate prevalence determinants vertebral fractures (VFs), that is, hallmark osteoporosis, in subjects with KS.Eighty-seven patients KS (median age 41 years, range 18-64) consecutively evaluated for radiological VFs (by quantitative morphometry) lumbar spine...
Background: antioxidants supplementation improves sperm quality, but few trials have analyzed the effects on DNA fragmentation (SDF). This study compares effectiveness of SOD-based antioxidant plus hydroxytyrosol and carnosol in reducing SDF with other without SOD, hydroxytyrosol, carnosol. Materials methods: men high at baseline were selected our clinical database. The patients taken into account had a 2-month control. was measured by Sperm Chromatin Dispersion test (SCD). Untreated used as...