A5033649447- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Atrial Fibrillation Management and Outcomes
- Cardiac electrophysiology and arrhythmias
- Cardiac Structural Anomalies and Repair
- Cardiac tumors and thrombi
- ECG Monitoring and Analysis
- Ion channel regulation and function
- Cardiomyopathy and Myosin Studies
- Neurological disorders and treatments
- Heart Failure Treatment and Management
- Venous Thromboembolism Diagnosis and Management
- Shape Memory Alloy Transformations
- Creativity in Education and Neuroscience
- COVID-19 Clinical Research Studies
- Cerebral Venous Sinus Thrombosis
- Lipoproteins and Cardiovascular Health
- Pathogenesis and Treatment of Hiccups
- Innovation Policy and R&D
- Thyroid Disorders and Treatments
- Diverse academic and cultural studies
- Cardiac Imaging and Diagnostics
- Stroke Rehabilitation and Recovery
- Vascular anomalies and interventions
- Cardiovascular Effects of Exercise
IRCCS Humanitas Research Hospital
2007-2024
Fondazione Humanitas per la Ricerca
1999-2024
Politecnico di Milano
2023
Humanitas University
2003-2022
National Research Council
2015
Institute for Energetics and Interphases
2015
University of Ferrara
2013
Istituti di Ricovero e Cura a Carattere Scientifico
2006-2010
Humanitas Gavazzeni
2005
University of Milan
1997
The flecainide test is widely used in Brugada syndrome. However, its reproducibility and safety remain ill-defined. This study included 22 patients (18 men, mean age 34 years). Mutations the SCN5A gene were found eight patients. Two had aborted sudden cardiac death, 8 syncope/presyncope, 12 asymptomatic. ECG was diagnostic 19 suggestive 3. At baseline, 21 of underwent a (2 mg/kg IV bolus over 10 minutes). In or amplified typical pattern. end drug infusion, sustained VT lasting 7-10 minutes...
Device replacement at the time of battery depletion implantable cardioverter-defibrillators (ICDs) may carry a considerable risk complications and engenders costs for healthcare systems. Therefore, ICD device longevity is extremely important both from clinical economic standpoint. Cardiac resynchronization therapy defibrillators (CRT-D) shorter than ICDs. We determined rate replacements we identified possible determinants early in series patients who had undergone implantation CRT-D devices....
Background Nonuniform recovery of ventricular excitability has been demonstrated to facilitate the reentry circuits leading development tachyarrhythmias. This can also occur in arrhythmogenic right dysplasia (ARVD). In fact, patients with ARVD, abnormalities repolarization are often observed on 12-lead ECGs, but their predictive value for occurrence malignant arrhythmias is yet be established. Because body-surface potential mapping proved useful detection heterogeneities even though they not...
Shape memory alloys (SMAs) are a very promising class of metallic materials that display interesting nonlinear properties, such as pseudoelasticity (PE), shape effect (SME) and damping capacity, due to high mechanical hysteresis internal friction. Our group has applied SMA in the field neuromuscular rehabilitation, designing some new devices based on mentioned properties: particular, type orthosis for spastic limb repositioning, which allows residual voluntary movement impaired no...
Inducibility of ventricular arrhythmias at programmed electrical stimulation (PES) ranges between 50% and 80% patients with Brugada syndrome. However, the variety PES protocols lack data relative to a control group or arrhythmia reproducibility contribute still undefined interpretation outcome in syndrome.Twenty-one syndrome (18 men 3 women; mean age 34 years; 9/21 symptomatic; 8/21 SCN5A gene mutation) underwent protocol from two right sites. The endpoint was completion induction sustained...
Background: Cardiac resynchronization therapy (CRT) improves cardiac performance and survival in patients with congestive heart failure. Recent observations suggest that diabetes is associated a worse outcome these patients. The aim of the study was to investigate effect insulin treatment on after CRT. Methods: Diabetic status were assessed 447 who underwent CRT (males 80.8%, mean age 65.7 ± 9.7 years, ejection fraction 29.9 6.11%). Patients stratified three groups according presence or...
Aim of the study: To examine long‐term effects cardiac resynchronization therapy (CRT) in patients presenting with heart failure (HF) and QRS ≤120 ms. Methods: This was a prospective, longitudinal study 376 [mean age = 65 years, mean left ventricular (LV) ejection fraction (EF) 29%, duration =165 ms, distance covered during 6‐minute hall walk (6‐MHW) 325 m], who underwent successful implantation CRT systems. The at baseline ms 45 (12%) were not pre‐selected by echocardiographic criteria...
GASPARINI, M., et al .: Biventricular Pacing via a Persistent Left Superior Vena Cava: Report of Four Cases. Persistence left superior vena cava (LSVC) is an uncommon finding during pacemaker implantation, which may be particularly relevant in performing LV transvenous pacing. Rarely, it further complicated by the presence atresia coronary sinus ostium (CSO). This article reports authors experience with biventricular pacing (Biv‐P) this unusual clinical setting. From October 1999 to April...
The ICD is an important treatment option in adults and children with life‐threatening tachyarrhvthmias. possibility of lead displacement caused by growth the lack dedicated leads cind devices poses special problems pediatric implantation. We describe our experience three whom we left a redundant loop within inferior vena cava (IVC) to allow for further growth. Since February 1998, underwent implantation at institution. A had (screw‐in) was advanced into right ventricular apex, created IVC...
Patients receiving cardiac resynchronization therapy defibrillators (CRT-Ds) are likely to undergo one or more device replacements, mainly for battery depletion. We assessed the economic impact of depletion on overall cost CRT-D treatment from perspectives healthcare system and hospital. also compared devices different generations manufacturers in terms cost. analysed data 1792 CRT-Ds implanted 1399 patients 9 Italian centres. calculated replacement probability total over 6 years, stratified...
Background: Defibrillation testing (DT) at the end of implantation cardiac resynchronization pacemaker with a defibrillator (CRT‐D) exposes heart failure (HF) patients to increased procedural risks. However, until now, delayed DT has not been assessed as possible option in HF implanted CRT‐D. Objective: Aim present study is assess safety and feasibility treated Material Methods: Two hundred eleven consecutive (mean age: 65 years, mean NYHA class 3.0, EF: 29.3%) underwent CRT‐D from October...
The feasibility and safety of transcatheter left atrial appendage occlusion with the WatchmanTM Device (Atritech Inc., Plymouth, MN, USA) for stroke prevention in fibrillation (AF) has recently been described. To our knowledge, a case huge thrombus formation on external surface this device not described so far. A …
Abstract Introduction Atrial fibrillation (AF) represents the most common arrhythmia in postoperative setting. We aimed to investigate incidence of AF (POAF) and determine its predictors, with a specific focus on inflammation markers. Methods performed retrospective single tertiary center cohort study including consecutive adult patients who underwent major surgical procedure between January 2016 2020. Patients were divided into four subgroups according type surgery. Results Among 53,387...
This article describes our experience with a staged “hybrid” approach to the treatment of drug resistant AF, in which completeness single linear lesion RA was verified noncontact mapping system. Inferior vena cava‐tricuspid annulus ablation performed and followed by creation intercaval lesion. The study population consisted 24 patients 3.4 ± 1.6‐year history resistant, severely symptomatic, lone paroxysmal (n = 19), or persistent 5) AF. During follow‐up 8 2.6 months, 12 (50%) remained...
Since cardiac resynchronization therapy (CRT) improves LV function at the cost of low energetic expenditure, authors hypothesized that it may increase threshold drug refractory angina in selected patients with CHF and CAD who are not amenable to myocardial revascularization. From October 1999 April 2002, 75 were treated CRT. Drug occurred nearly daily 8 patients. The mean age these eight men was 71 years, NYHA functional Class 3.4 +/- 0.5, QRS duration (QRSd) 168 20 ms, left ventricular...