A5038846186- Parathyroid Disorders and Treatments
- Thyroid and Parathyroid Surgery
- Esophageal Cancer Research and Treatment
- Esophageal and GI Pathology
- Genetic Syndromes and Imprinting
- Gastric Cancer Management and Outcomes
- Medical Imaging and Pathology Studies
- Thyroid Cancer Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Metastasis and carcinoma case studies
- Tracheal and airway disorders
- Pituitary Gland Disorders and Treatments
- Medical and Biological Sciences
- Lung Cancer Diagnosis and Treatment
- Bone health and treatments
- Gastroesophageal reflux and treatments
- Gastrointestinal disorders and treatments
- Galectins and Cancer Biology
- Gastrointestinal Tumor Research and Treatment
- Cancer Diagnosis and Treatment
- Nuclear Structure and Function
- History of Medical Practice
- Neuroendocrine Tumor Research Advances
- Vitamin D Research Studies
- Colorectal Cancer Surgical Treatments
University of Turin
2005-2023
Fondazione Ricerca Molinette
2013-2023
Azienda Ospedaliera Citta' della Salute e della Scienza di Torino
2014
University of Pisa
2008-2013
Azienda Ospedaliero Universitaria San Giovanni Battista
1991-2012
Ospedale Civile Di Ivrea
2006
To determine, in a series of patients with secondary and tertiary parathyroid hyperplasia, whether the type parathyroidectomy (subtotal, total autotransplantation, or total), histologic pattern tissue, proliferative index, as determined by Ki-67 analysis, could predispose to recurrent hyperparathyroidism.Recurrent hyperparathyroidism appears 10--70% undergoing surgery for hyperparathyroidism. The incidence be related operation (Rothmund) but also depends on glands removed (Niederle).The...
Inactivating mutations of the CDC73 tumor suppressor gene have been reported in parathyroid carcinomas (PC), association with loss nuclear expression encoded protein, parafibromin. The aim this study was to further investigate role PC and evaluate whether carrier status and/or parafibromin staining might an effect on outcome disease. We performed genetic immunohistochemical studies samples from 35 patients sporadic PC. Nonsense or frameshift were detected 13 suitable for DNA sequencing. Six...
Extensive resection of the tumor has been associated with better survival anaplastic thyroid carcinoma (ATC) patients. However, surgery is not rule for ATC patients distant metastases at time diagnosis (stage IV-C), regardless resectability. The aim this work was to explore potential role in patients, including those stage IV-C.We considered all consecutive referred our institution from June 1999 July 2012. Patients IV-A incidentally discovered were excluded because their prognosis. All...
In Brief Background: Persistent secondary or tertiary hyperparathyroidism (HPT) results from failure to remove enough hyperfunctioning parathyroid tissue. Ectopically situated glands and supernumerary make more likely. Recurrent HPT after subtotal Ptx is usually due regrowth of the remaining Recurrence may also develop a hyperplastic gland rarely parathyromatosis. total with autotransplantation overgrowth autograft for previously mentioned reasons. Methods: Since 1995, 464 patients SHPT THPT...
Parathyroid cancer (PC) is a rare sporadic or hereditary malignancy whose histologic features were redefined with the 2022 WHO classification. A total of 24 Italian institutions designed this multicenter study to specify PC incidence, describe its clinical, functional, and imaging characteristics improve differentiation from atypical parathyroid tumour (APT).All relevant information was collected about APT patients treated between 2009 2021.Among 8361 parathyroidectomies, 351 (mean age 59.0...
Abstract Purpose. To evaluate the sensitivity, specificity, and usefulness of dual‐phase 99mTc‐Sestamibi scintigraphy (SS) sonography (US) neck, alone in combination, as noninvasive adenoma localizing procedures patients with primary hyperparathyroidism prior to parathyroidectomy. Methods. We retrospectively analyzed charts 79 parathyroid (PT) adenomas confirmed diagnosis who were evaluated SS US successful Results. Ninety‐three removed during bilateral neck exploration. showed a sensitivity...
Hyperplastic and neoplastic parathyroid lesions may present overlapping morphologic features, several markers have been proposed to distinguish benign from malignant growths. Recently, it was reported that galectin-3 is a useful marker of malignancy in uniglandular diseases. To investigate Ki-67 immunoexpression hyperplastic disease, 63 multiglandular (13 primary, 40 secondary, 10 tertiary hyperplasia cases) were analyzed compared with 45 control cases adenomas 24 carcinomas. Our data showed...
Giant fibrovascular polyps are uncommon benign esophageal tumors almost always originating from the cervical esophagus, frequently upper sphincter. The case of a 74-year-old man with long history dysphagia and weight loss 9 kg is presented. Neither barium esophagogram, computed tomogram or magnetic resonance imaging correctly evidenced lesion. Only fiberoptic endoscopy suggested correct diagnosis because mass fluctuated endoluminally spasm vomiting. A left exploratory incision esophagotomy...
The usefulness of intraoperative parathyroid hormone (PTH) monitoring has been extensively documented in primary hyperparathyroidism (HPT), whereas few data have published on its use reoperations or secondary and tertiary HPT. We report our initial experience with a rapid (12 min response) PTH immunochemiluminometric assay performed the operating room during surgery 12 patients HPT, 16 end-stage renal disease HPT five kidney transplanted subjects Blood samples were taken at baseline, within...
Thirty percent of carcinomas the pyriform sinus manifest generally with infiltrations in cervical esophagus. In recent years, progress reconstructive surgery has broadened surgical indications to include tumors previously managed palliative measures alone. some cases, radical been extended creating safer resection margins, more and for circular pharyngectomy. Lesions involving hypopharyngoesophageal junction pose particular problems; furthermore, high rate synchronous or metachronous...