Giuseppa Graceffa
A5047602773- Breast Cancer Treatment Studies
- Thyroid and Parathyroid Surgery
- Thyroid Cancer Diagnosis and Treatment
- Breast Lesions and Carcinomas
- Cancer and Skin Lesions
- BRCA gene mutations in cancer
- Thyroid Disorders and Treatments
- Cancer Diagnosis and Treatment
- Gastrointestinal disorders and treatments
- Genetic factors in colorectal cancer
- Gastroesophageal reflux and treatments
- Multiple and Secondary Primary Cancers
- Parathyroid Disorders and Treatments
- Voice and Speech Disorders
- Heat shock proteins research
- Head and Neck Anomalies
- Cancer Treatment and Pharmacology
- Breast Implant and Reconstruction
- Advanced Breast Cancer Therapies
- Extracellular vesicles in disease
- Radiation Dose and Imaging
- Gastrointestinal Tumor Research and Treatment
- Airway Management and Intubation Techniques
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Surgical Treatments
University of Palermo
2010-2025
Azienda Ospedaliera Universitaria Policlinico "Paolo Giaccone" di Palermo
2012-2024
University of Cagliari
2023
Several studies report a higher rate of papillary thyroid carcinomas (PTC) in patients with Hashimoto thyroiditis (HT), indicating possible correlation between the two diseases. We studied group 89 subjects undergoing surgery for compared control operated on normofunctioning goiter, and second 47 total thyroidectomy HT. Association HT was found 19 71 PTC (26.7%) 8 goiter (8.9%), which significant difference ( P < 0.02). Thirteen patients, mostly nodular form, showed coexistent (27.6%)....
The association between Hashimoto's thyroiditis (HT) and papillary thyroid carcinoma (PTC) is a controversial question that still under debate, its pathological significance the eventual clinical implications of this remaining unclear.The data regarding 305 patients were retrospectively analyzed. divided in two different groups. A first group made up 142 undergoing surgery for differentiated was compared to control analogous subjects operated normofunctioning goiter. second 163 who had...
The thyroid is a major component of the endocrine system and its pathology can cause serious diseases, e.g., papillary carcinoma (PC). However, carcinogenic mechanisms are poorly understood clinical useful biomarkers scarce. Therefore, we determined if there quantitative patterns molecular chaperones in tumor tissue circulating exosomes that may be diagnosis provide clues on their participation carcinogenesis. Hsp27, Hsp60, Hsp70, Hsp90 were quantified by immunohistochemistry PC, benign...
Abstract A task force of the United Italian society Endocrine Surgery (SIUEC) was commissioned to review position statement on diagnostic, therapeutic and health‑care management protocol in thyroid surgery published 2016, at light new technologies, recent oncological concepts, tailored approaches. The objective this publication support surgeons with modern rational protocols treatment that can be shared by health-care professionals, taking into account important clinical, healthcare aspects,...
Abstract Background Seroma formation frequently occurs in patients who have undergone axillary lymphadenectomy. The aim of the study was to evaluate effect fibrin glue prevention seroma after Materials and Methods Hundred fifty‐nine breast cancer about undergo quadrantectomy or mastectomy plus lymphadenectomy were enrolled randomized into two groups. Fibrin spray applied fossa placement closed suction drainage used 80 (group A); only 79 B). Results Group A showed a slight advantage with...
Abstract The outbreak of the COVID-19 pandemic has led to a disruption surgical care. aim this multi-centric, retrospective study was evaluate impact on activity for thyroid disease among Italian Units Endocrine Surgery. Three phases were identified based epidemiological situation and public measures adopted from Government (1st phase: 9th March 3rd May 2020; 2nd 4th 14th June; 15th June 31st). patients operated upon during these compared those who underwent surgery same period previous...
Secretory mammary carcinoma is a rare breast neoplasia originally described in children but sometimes also found adults. It presents more favourable outcome than common histological types of carcinoma; published literature fact reports only few cases with axillary lymph node metastases and four distant metastases. In this paper we report case secretory 33-year-old woman. To our knowledge, the first involving biopsy sentinel investigation e-cadherin expression. We positivity for e-cadherin,...
Parathyroid cancer (PC) is a rare sporadic or hereditary malignancy whose histologic features were redefined with the 2022 WHO classification. A total of 24 Italian institutions designed this multicenter study to specify PC incidence, describe its clinical, functional, and imaging characteristics improve differentiation from atypical parathyroid tumour (APT).All relevant information was collected about APT patients treated between 2009 2021.Among 8361 parathyroidectomies, 351 (mean age 59.0...
Background: The incidence of various types cancer, for example, papillary thyroid carcinoma (PTC), is on the rise. Since therapeutic success depends greatly early diagnosis, reliable diagnostic biomarkers must be identified, and easy-to-apply tools detecting them urgently standardized. Here, we contribute to solving this medical challenge by assessing miRNAs suspected promoting carcinogenesis in extracellular vesicles (EVs) that can routinely obtained via liquid biopsy. We profit from...
Gastrointestinal stromal tumour (GIST) is a rare of the gastrointestinal tract which does not generally originate in rectum. The authors describe case 70-year-old man who underwent an anterior resection rectum for low-risk GIST. patient was given adjuvant chemotherapy with imatinib and still disease-free 30 mo after surgery. conclude that although rectal GIST extremely uncommon, it should be included differential diagnosis when detected. Biopsy essential, since this makes possible to reach...
The aim of this study was to evaluate the current role frozen section in identifying patients who could benefit from an immediate axillary lymph node dissection (ALND), following criteria ASOCOG Z0011 and IBCSG 23-10 trials.A retrospective review performed involving 2,079 with early breast cancer underwent conservative surgery or total mastectomy sentinel biopsy.Sensitivity diagnostic accuracy were 63.8% 90.3%, respectively. Sensitivity significantly higher (p<0.001) finding macrometastases...
Thyroidectomy is the preferred approach as definitive treatment for Graves' disease. The outcomes total thyroidectomy in a large series of 594 patients, who were observed last decade, will be presented this study.The study concerned retrospective review undergoing incidence complications and on hyperthyroidism correlated symptoms resolution also evaluated.The mean age patients was 44.7 ± 12.7 years 456 (76.7%) females. gland weight 67.3 10.8 g (range: 20-350 g) and, 397 (66.8%), weighed >40...
Mushroom extracts are a rich source of natural compounds with antimicrobial properties, which able to prevent, some extent, the growth foodborne pathogens. The aim this study was investigate potential from albino Grifola frondosa (GF), commonly known as maitake, inhibit bacteria and biofilm production by Staphylococcus aureus. We obtained not only significant reduction OD score between plus G. extract group, but also category biofilm. In addition, we observed presence isolates strong for...
Intraoperative parathyroid hormone dosage allows real-time monitoring of the decrease in PTH levels during parathyroidectomy and verify procedure's efficacy. Currently, none interpretative criteria used has absolute accuracy. The aim this study is to evaluate diagnostic accuracy Rome criterion verifying significance individual assays. A total 205 patients with primary hyperparathyroidism from a single adenoma were retrospectively evaluated monitored baseline PTH, at 10 min 20 after excision....