A5048657538- PARP inhibition in cancer therapy
- DNA Repair Mechanisms
- Extracellular vesicles in disease
- BRCA gene mutations in cancer
- Thyroid and Parathyroid Surgery
- Autism Spectrum Disorder Research
- Gastrointestinal Tumor Research and Treatment
- Cell death mechanisms and regulation
- Genetics and Neurodevelopmental Disorders
- Lung Cancer Diagnosis and Treatment
- Thyroid Cancer Diagnosis and Treatment
- Big Data Technologies and Applications
- Cancer Immunotherapy and Biomarkers
- Ovarian cancer diagnosis and treatment
- Bone health and osteoporosis research
- MicroRNA in disease regulation
- Sarcoma Diagnosis and Treatment
- Research Data Management Practices
- Parathyroid Disorders and Treatments
- Cancer Genomics and Diagnostics
- Scientific Computing and Data Management
- Immune Cell Function and Interaction
- Lung Cancer Treatments and Mutations
- Genetic factors in colorectal cancer
- Voice and Speech Disorders
University of Palermo
2021-2025
University of Rome Tor Vergata
2022-2024
Abstract The SIGnaling Network Open Resource (SIGNOR 3.0, https://signor.uniroma2.it) is a public repository that captures causal information and represents it according to an ‘activity-flow’ model. SIGNOR provides freely-accessible static maps of interactions can be tailored, pruned refined build dynamic predictive models. Each signaling relationship annotated with effect (up/down-regulation) the mechanism (e.g. binding, phosphorylation, transcriptional activation, etc.) causing regulation...
Intraoperative parathyroid hormone dosage allows real-time monitoring of the decrease in PTH levels during parathyroidectomy and verify procedure's efficacy. Currently, none interpretative criteria used has absolute accuracy. The aim this study is to evaluate diagnostic accuracy Rome criterion verifying significance individual assays. A total 205 patients with primary hyperparathyroidism from a single adenoma were retrospectively evaluated monitored baseline PTH, at 10 min 20 after excision....
Anaplastic thyroid carcinoma (ATC) is a very rare and extremely aggressive disease with poor prognosis. Several risk factors have been hypothesized, but there no clear-cut literature data on it. We reviewed the concerning for ATC analyzed institutional database from 2005 to 2022. In total, 15 papers were suitable review, while retrospective collection search, conducted our database, provided 13 results. experience, in agreement data, seems be neoplasm peculiar old age (in mean 72 years),...
Autism spectrum disorder (ASD) comprises a large group of neurodevelopmental conditions featuring, over wide range severity and combinations, core set manifestations (restricted sociality, stereotyped behavior language impairment) alongside various comorbidities. Common rare variants in several hundreds genes regulatory regions have been implicated the molecular pathogenesis ASD along causation evidence strength. Despite significant progress elucidating impact few paradigmatic individual...
10592 Background: Testing for BRCA mutations (BRCAm) and genomic instability can identify epithelial ovarian cancer (OC) patients most likely to benefit from PARP-inhibitors (PARPi). However, current biomarkers of non- Homologous Recombination Repair (HRR) are insufficient guiding use PARPi in the clinic. Despite HRR pathway gene rare, these may PARPi. Furthermore, recent preclinical findings showed that sensitivity could be associated also with mismatch repair (MMR) genes, although clinic...