A5028924060- Cancer Cells and Metastasis
- Pancreatic and Hepatic Oncology Research
- Animal Genetics and Reproduction
- Cancer Research and Treatments
- Breast Cancer Treatment Studies
- Animal testing and alternatives
- Pancreatic function and diabetes
- Peripheral Artery Disease Management
- Radiation Dose and Imaging
- Cardiovascular Disease and Adiposity
- Thyroid Cancer Diagnosis and Treatment
- Esophageal Cancer Research and Treatment
- Animal and Plant Science Education
- Advanced Breast Cancer Therapies
- HER2/EGFR in Cancer Research
- Innovation Policy and R&D
- Adrenal and Paraganglionic Tumors
- Cardiovascular Function and Risk Factors
- Innovations in Medical Education
- Traumatic Brain Injury Research
- Virus-based gene therapy research
- Global Cancer Incidence and Screening
- Medical Education and Admissions
- Diagnosis and Treatment of Venous Diseases
- Surgical Sutures and Adhesives
University of Nebraska Medical Center
2020-2025
University of Nebraska at Omaha
2023-2024
Westchester Medical Center
2024
Imperial College London
2023
Hammersmith Hospital
2023
University of Cagliari
2023
VA Nebraska Western Iowa Health Care System
2022
Omaha VA Medical Center
2021
University of Oklahoma
2011
The 5-year survival of pancreatic cancer (PC) remains low. Murine models may not adequately mimic human PC and can be too small for medical device development. A large-animal model could address these issues. We induced characterized tumors in Oncopigs (transgenic swine containing KRASG12D TP53R167H). oncopigs underwent injection adenovirus expressing Cre recombinase (AdCre) into one the main ducts. Resultant were by histology, cytokine expression, exome sequencing transcriptome analysis....
Abstract We describe our initial studies in the development of an orthotopic, genetically defined, large animal model pancreatic cancer. Primary epithelial cells were isolated from duct domestic pigs. A transformed cell line was generated these primary with oncogenic KRAS and SV40T. The lines outperformed SV40T immortalized terms proliferation, population doubling time, soft agar growth, transwell migration invasion. grew tumors when injected subcutaneously nude mice, forming glandular...
Rivers and streams are among the most threatened ecosystems worldwide, their fish assemblages have been modified by anthropogenic habitat alteration introductions of non‐native species. Consequently, two frequently observed patterns assemblage change over time species loss biotic homogenization. In present study, we compared contemporary (2006–2007) historical (1948–1955) darters, a group small benthic fishes family Percidae, in Arkansas River drainage northeastern Oklahoma, USA. Results...
Prosthetic and orthotic devices are assistive utilized by individuals with limb loss, difference, mobility impairment. Research has shown these improve functionality, independence, overall quality of life for disabilities who depend on them. This report focuses two use types prosthetic devices: general-use activity-specific. General-use prostheses orthoses designed to achieve the basic needs ambulation upper-limb functionality. In contrast, activity-specific support higher-intensity physical...
Neoadjuvant chemoimmunotherapy with pembrolizumab now defines the standard of care for early high-risk triple-negative breast cancer (TNBC). However, role in neoadjuvant therapy (NAT) estrogen receptor-positive (ER+) remains uncertain. A 39-year-old G2P2 female discovered a palpable mass right while breastfeeding her 7-month-old child, leading to diagnosis high-grade ER+ (80% moderate staining), human epidermal growth factor receptor 2-negative (ErbB2-) invasive ductal carcinoma axillary...
Background: There is ongoing need for large animal models of peripheral artery disease (PAD) that replicate human disease. We present mild (MI), moderate (MD) and Severe (S) phenotypes PAD in an Ossabaw mini-swine platform. Methods: Metabolic syndrome was induced swine (N=16; age= 4 mo) with a high fat/fructose/sodium diet 8 weeks. Ischemia induction (T0) consisted of: (1) open ligation resection R Superficial Femoral Artery (SFA) MI(N=4); (2) endovascular coil occlusion External Iliac...
Abstract We describe our initial studies in the development of an orthotopic, genetically-defined, large animal model pancreatic cancer. Primary epithelial cells were isolated from duct domestic pigs. A transformed cell line was generated these primary with oncogenic KRAS and SV40T. The lines outperformed SV40T immortalized terms proliferation, population doubling time, soft agar growth, transwell migration invasion. grew tumors when injected subcutaneously nude mice, forming glandular...
Abstract We describe our initial studies in the development of an orthotopic, genetically-defined, large animal model pancreatic cancer. Primary epithelial cells were isolated from duct domestic pigs. A transformed cell line was generated these primary with oncogenic KRAS and SV40T. The lines outperformed SV40T immortalized terms proliferation, population doubling time, soft agar growth, transwell migration invasion. grew tumors when injected subcutaneously nude mice, forming glandular...
floor to hopefully reduce LOS even further.
significantly reduced hospital length of stay for patients with ASBOs.We are now piloting a revised pathway that can occur anytime on the floor to hopefully reduce LOS even further.
can occur anytime on the floor to hopefully reduce LOS even further.
can occur anytime on the floor to hopefully reduce LOS even further.
can occur anytime on the floor to hopefully reduce LOS even further.
can occur anytime on the floor to hopefully reduce LOS even further.