A5010729269- Thyroid Cancer Diagnosis and Treatment
- Head and Neck Anomalies
- BRCA gene mutations in cancer
- COVID-19 and healthcare impacts
- Radiomics and Machine Learning in Medical Imaging
- Meta-analysis and systematic reviews
- Radiation Dose and Imaging
- Adrenal Hormones and Disorders
- Salivary Gland Tumors Diagnosis and Treatment
- Diabetes and associated disorders
- Sepsis Diagnosis and Treatment
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Diabetes Management and Research
- Thyroid and Parathyroid Surgery
- Clinical Reasoning and Diagnostic Skills
The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute
2019-2024
The Ohio State University
2019-2024
The Ohio State University Wexner Medical Center
2024
University of Cagliari
2023
Diabetes Australia
2019
Background: The Afirma Gene Expression Classifier (GEC) has been used to further characterize cytologically indeterminate (cyto-I) thyroid nodules into either benign or suspicious categories. However, its relatively low positive predictive value (PPV) limited use as a classifier for patients with results. Sequencing (GSC) was developed improve PPV while maintaining high negative (NPV), yet real-world assessment of performance is lacking. Methods: We analyzed all who had cyto-I and molecular...
The Bethesda system classifies all fine-needle aspiration specimens into 1 of 6 categories. We speculated that cancers within each category would have distinct clinical behavior.
Abstract Background Cytologically indeterminate thyroid nodules (ITN) pose a management challenge. Here we analyze if adding ultrasound characteristics to Afirma Genome Sequence Classifier (GSC) results increases GSC diagnostic performance. Methods We retrospectively analyzed 237 GSC-tested Bethesda III/IV ITNs between July 2017 and December 2019 classified them by American Thyroid Association (ATA) the Imaging Reporting Data System (TIRADS) of College Radiology. Results The benign call rate...
Abstract Background Most cytologically indeterminate thyroid nodules (ITNs) with benign molecular testing are not surgically removed. The data on clinical outcomes of these limited. Methods We retrospectively analyzed all ITNs where was performed either the Afirma gene expression classifier or sequencing between 2011 and 2018 at a single institution. Results Thirty-eight out 289 molecularly were ultimately resected. most common reason for surgery compressive symptoms (39%). In multivariable...
Abstract Background Patients with sporadic or hereditary Medullary Thyroid Carcinoma (MTC) often undergo total thyroidectomy and lymph node dissection, postoperative surveillance relying on serum calcitonin levels ultrasound examinations. According to American Association (ATA) guidelines, detectable of Carcinoembryonic Antigen (CEA) post-thyroidectomy suggest potential disease persistence recurrence, necessitating frequent monitoring for early detection. This study sought reassess the role...
Abstract Objective: Evaluation and management of thyroid nodules with cytologically indeterminate results remain challenging in clinical practice. Despite the implementation molecular testing an attempt to avoid surgical intervention, diagnostic thyroidectomy still occurs due relatively low positive predictive value these testing. We conducted a study analyze whether combining US characteristics would better elucidate predicting true results. Methods: retrospectively reviewed ultrasound...