A5066652743- Adrenal and Paraganglionic Tumors
- Hormonal Regulation and Hypertension
- Thyroid Cancer Diagnosis and Treatment
- Pituitary Gland Disorders and Treatments
- Thyroid and Parathyroid Surgery
- Parathyroid Disorders and Treatments
- Adrenal Hormones and Disorders
- Neuroendocrine Tumor Research Advances
- Cancer, Hypoxia, and Metabolism
- Radiomics and Machine Learning in Medical Imaging
- COVID-19 and healthcare impacts
- Radiation Dose and Imaging
- Cancer Diagnosis and Treatment
- Renin-Angiotensin System Studies
- Head and Neck Anomalies
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Soft tissue tumor case studies
- Thyroid Disorders and Treatments
- Blood Pressure and Hypertension Studies
- S100 Proteins and Annexins
- Receptor Mechanisms and Signaling
- Ultrasound in Clinical Applications
- Medical Imaging and Pathology Studies
- Vascular Tumors and Angiosarcomas
- Protease and Inhibitor Mechanisms
University of Padua
2013-2024
University of Cagliari
2021-2023
Geneeskundige en Gezondheidsdienst
2022
St. Eugenio Hospital
2021
General Department of Preventive Medicine
2013
Medicina
1994
University of Bologna
1989
Adrenocortical cancerACC is an exceedingly rare tumour, with estimated incidence of 1-2 per million population year, and overall 5-year survival rate only 30 cent.The ranges from 60 to 80 cent for tumours confined the adrenal gland, 35 50 locally advanced disease, much lower patients metastatic disease (below cent) 3 .
The main challenge in the management of indeterminate incidentally discovered adrenal tumours is to differentiate benign from malignant lesions. In absence clear signs invasion or metastases, imaging techniques do not always precisely define nature mass. present pilot study aimed determine whether radiomics may predict malignancy adrenocortical tumours.CT images unenhanced, arterial, and venous phases 19 patients who had undergone resection a cohort surveillance for at least 5 years...
Abstract Background: The current preoperative diagnosis of a thyroid mass relies on microscopic evaluation cells obtained by fine needle aspiration biopsy (FNAB). More recently, FNAB has been combined with molecular analysis to increase the accuracy cytological evaluation. In this mono-institutional prospective study, we evaluated whether routine introduction BRAF testing in could help ameliorate recognition papillary carcinoma (PTC) “suspended” or malignant categories. Moreover,...
Abstract The outbreak of the COVID-19 pandemic has led to a disruption surgical care. aim this multi-centric, retrospective study was evaluate impact on activity for thyroid disease among Italian Units Endocrine Surgery. Three phases were identified based epidemiological situation and public measures adopted from Government (1st phase: 9th March 3rd May 2020; 2nd 4th 14th June; 15th June 31st). patients operated upon during these compared those who underwent surgery same period previous...
Radiomics is a promising research field that combines big data analysis (from tissue texture analysis) with clinical questions. We studied the application of CT in adrenal pheochromocytomas (PCCs) to define correlation between extracted features and secretory pattern, histopathological data, natural history disease. A total 17 patients affected by surgically removed PCCs were retrospectively enrolled. Before surgery, all underwent contrast-enhanced complete endocrine evaluation...
Abstract Context Accumulating evidence suggests a link between adrenocortical zona glomerulosa and parathyroid gland through mechanisms that remain unexplored. Objectives To test the hypothesis in vivo angiotensin II blockade affects PTH secretion patients with hypertension aldosterone angiotensim directly stimulate ex vivo. Design Setting We investigated changes of serum levels induced by oral captopril (50 mg) administration primary essential (EH) aldosteronism (PA) caused bilateral...
We aimed to evaluate the role of adrenal multidisciplinary team evaluation (MTE) in affecting overall survival (OS) and progression-free (PFS) patients with adrenocortical carcinoma (ACC). included a retrospective monocentric study 47 ACC. divided our cohort into group 1 (without adrenal-MTE discussion, ACC diagnosis from 2004 2012, n = 14) 2 (diagnosis beginning treatments after 2013, all discussed MTE, 33). OS was defined by between first last visit, while PFS as time visit progression...
Background: The prognosis of pheochromocytoma and sympathetic paraganglioma (PHEO/sPGL) is difficult to predict at the time diagnosis long-term follow-up data are scarce, especially for apparently benign sporadic variants. aim study was analyze outcomes in PHEO/sPGL patients. Methods: A monocentric series 170 patients who underwent surgery analyzed. Results: cohort included 91 female 79 males with a median age 48 years (range 6–83). majority cases were considered diagnosis; evident malignant...
The International Medullary Thyroid Carcinoma Grading System (IMTCGS) divides medullary thyroid carcinoma (MTC) into two categories, high- and low-grade tumors, which has a profound impact on patient outcomes. aim of this study was to explore the association between IMTCGS grading, clinical data, molecular status in sporadic MTC.
Abstract Background Lugol solution is often administered to patients with Graves’ disease before surgery. The aim reduce thyroid vascularization and surgical morbidity, but its real effectiveness remains controversial. present study was designed evaluate the effects of preoperative on morbidity in undergoing total thyroidectomy. Methods Fifty-six thyroidectomy for were randomly assigned receive 7 days treatment (Lugol+ group, 29) or no (LS– 27) surgery this single-centre single-blinded...
Prophylactic thyroidectomy has been encouraged for children with REarranged during Transfection (RET) germline mutations to prevent the onset, persistence, or recurrence of medullary thyroid carcinoma (MTC). The American Thyroid Association (ATA) recently published guidelines on timing prophylactic thyroidectomy. Our aim here was seek information optimal surgery carriers RET gene no clinical evidence disease, bearing in mind ATA recommendations.From 1986 2012, total performed at our...
Primary aldosteronism (PA) is associated with an increased prevalence of anxiety and depression. Subnormal quality life (QoL) scores in PA patients may be improved after surgical treatment. The aim the study was to assess impact surgery on health-related QoL depression status suffering from PA, comparing results a control group undergoing for non-secreting adrenal tumors. Data were prospectively collected, January 2014 2017, before, early (at 1 month) at late follow up least 6 months)...
The angiotensin II (Ang II) type 2 receptor (AT2R) and the angiotensin-(1-7) (Ang-(1-7)) (MasR) play a cardiovascular protective role by counter-regulating Ang 1 (AT1R)-mediated effects, but whether this involves blunting of adrenocortical hormone secretion is unknown. We investigated presence AT1R, AT2R, MasR in aldosterone-producing adenoma (APA), condition featuring hyperaldosteronism, APA-adjacent tissue. effect Compound 21 (C21), an AT2R agonist, on CYP11B1 (cortisol synthase) CYP11B2...
Drug-resistant hypertension (RH) is a very high-risk condition involving many hypertensive patients, in whom primary aldosteronism (PA) commonly overlooked. Hence, we aimed at determining if (1) adrenal vein sampling (AVS) can identify PA RH who are challenging because of receiving multiple interfering drugs; (2) AVS-guided adrenalectomy resolve high blood pressure (BP) resistance to treatment these patients. Based on pilot study selected from 1016 consecutive patients referred our Centre...
Primary aldosteronism (PA) is a disease characterized by high aldosterone levels caused benign adrenal tumors being the most frequent cause of secondary hypertension. Aldosterone plays vital physiological roles through mineralocorticoid receptor (MR) but in certain cell types, it can also activate glucocorticoid (GC) (GR). Both MR and GR are structurally functionally related belong to same family ligand-dependent transcription factors that recognize identical GC regulatory elements (GREs) on...
The identification of submandibular ectopic normal thyroid in the lateral neck with a coexisting normally located and functional gland is rare. Ectopic tissue midline location most commonly related to aberrant migration along thyroglossal duct (ie, lingual thyroid). A 54-year-old man 6-month history visible asymptomatic swelling right region had ultrasonography Tc-99m pertechnetate imaging.