A5003640178- Pituitary Gland Disorders and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Adrenal and Paraganglionic Tumors
- Neuroendocrine Tumor Research Advances
- Reproductive tract infections research
- Hormonal and reproductive studies
- Cardiovascular Function and Risk Factors
- Metabolism, Diabetes, and Cancer
- Cerebrovascular and Carotid Artery Diseases
- Pharmaceutical studies and practices
- Cerebral Venous Sinus Thrombosis
- Diet and metabolism studies
- Pelvic floor disorders treatments
- Sexual Differentiation and Disorders
- Estrogen and related hormone effects
- Meningioma and schwannoma management
- Histiocytic Disorders and Treatments
- Chemokine receptors and signaling
- COVID-19 and healthcare impacts
- Long-Term Effects of COVID-19
- Urinary Tract Infections Management
- Receptor Mechanisms and Signaling
- Neurofibromatosis and Schwannoma Cases
- Regulation of Appetite and Obesity
- Bone Tumor Diagnosis and Treatments
University of Naples Federico II
2018-2025
Federico II University Hospital
2019-2024
Pasireotide is a novel therapeutic option for patients with acromegaly resistant to first-generation somatostatin receptor ligands. To date, real-life data are still scant, therefore, the aim of current study evaluate impact long-term pasireotide therapy on disease control, pituitary tumor size, gluco-insulinemic and lipid profile in setting. Retrospective prospectively collected, evaluating hormonal, tumoral, metabolic 28 administered tertiary referral center. Within first 12 months...
Hyperprolactinaemia has been implicated in the pathogenesis of obesity and glucose intolerance is reportedly associated with impaired metabolic profile syndrome approximately one third patients.Suppression dopaminergic tone proposed as a potential mechanism responsible for weight gain abnormalities such patients. Dopamine receptor type 2 (D2R) abundantly expressed on human pancreatic β-cell adipocytes, suggesting regulatory role peripheral dopamine insulin adipose functions. Medical...
COVID-19 pandemics and cardiometabolic health are mutually interconnected. Chronic metabolic diseases known risk factors for increased mortality after SARS-CoV-2 infection. In turn, COVID imposed sudden changes in lifestyle social isolation with consequent potential sequelae. The present study aimed at investigating the impact of life on profile hyperprolactinemic or osteoporotic patients without pre-existing time COVID-19.
Pegvisomant (PEG) efficaciously controls IGF-I excess in acromegaly and possesses a positive impact on glucose metabolism. Data very prolonged PEG treatment are still limited, therefore, we investigated the effects of 10-years disease control, maximal tumour diameter (MTD), metabolic profile consecutive patients resistant to somatostatin analogues (SRLs) followed an European referral centre for acromegaly. Since 2000s, collected data anthropometric, hormonal parameters, MTD receiving PEG. In...
Abstract Purpose Cardiac abnormalities are common in patients with acromegaly, contributing to the increased morbidity and mortality. magnetic resonance (CMR) is gold standard for measuring cardiac morpho-functional changes. This study aims detect alterations acromegaly through CMR, even when disease adequately controlled. Methods In this, multicentre, case-control study, we compared consecutive cured after surgery or requiring medical treatment, matched controls recruited among harbouring...
Context Colonic polyps occur in 30–40% of acromegalic patients, increasing the risk colon carcinoma. Although debated, there is emerging evidence that metformin may play a protective role diabetic and non-diabetic patients with colonic its use chemoprevention currently explored. Objective Evaluate prevalence treated or not explore possible role. Design Exploratory cross-sectional study two tertiary Italian referral centres. Met hods: Out 153 we selected 58 (36–82 years; f: 33) who had at...
Abstract Context Fertility represents a major concern in patients with acromegaly. Objective The current retrospective study aimed to investigate gonadal function and fertility rates acromegalic women. Methods In this referral-center study, 50 women disease onset within reproductive age were evaluated for prevalence of dysfunction infertility. Anthropometric, metabolic, hormonal parameters, gynecological ultrasound at diagnosis after control. Data about menstrual disturbances, pregnancy,...
Objective Control of prolactin excess is associated with the improvement in gluco-insulinemic and lipid profile. The current study aimed at investigating effects pituitary surgery medical therapy high dose cabergoline (≥2mg/week) on metabolic profile patients prolactinoma resistant to conventional doses (<2mg/week). Design Thirty-four (22 men, 12 women, aged 33.9 ± 12.5 years) (4 microadenomas 30 macroadenomas) were included present study. Among them 17 (50%) received (PS, Group1)...
Abstract Purpose Impairment of skeletal muscle mass and strength affects 40–70% patients with active Cushing’s syndrome (CS). Glucocorticoid excess sustains atrophy weakness, while muscle-specific microRNAs (myomiRs) level changes were associated organization function perturbation. The aim the current study is to explore in circulating myomiRs CS compared healthy controls their involvement IGFI/PI3K/Akt/mTOR pathway regulation muscle. Methods C2C12, mouse myocytes, exposed hydrocortisone...
Abstract Background Sellar/parasellar lesions have been studied in the adult and paediatric age range, but during transition their epidemiology, clinical manifestations, management treatment outcomes poorly investigated. Materials methods An Italian multicentre cohort study, which hospital records of patients with diagnosis sellar/parasellar young adulthood (15–25 years), were reviewed terms prevalence, hormonal features at diagnosis, where available. Both pituitary neuroendocrine tumours...
Several multi-kinase inhibitors were widely tested as potential first-line or second-line therapy in patients with advanced hepatocellular carcinoma (HCC). However, acquired drug resistance limits their clinical efficacy. Exosomes are microvesicles secreted by tumor and stromal cells that participate many biological processes, including resistance. The current study evaluated the capability of exosomes derived from everolimus (EVE)-resistant HCC inducing parental human effect 1,25(OH) 2...