A5064225963- Endometrial and Cervical Cancer Treatments
- COVID-19 and healthcare impacts
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Cardiac, Anesthesia and Surgical Outcomes
- Uterine Myomas and Treatments
- Trauma and Emergency Care Studies
- Ovarian cancer diagnosis and treatment
- Intraperitoneal and Appendiceal Malignancies
- Microbial Inactivation Methods
- Cancer-related molecular mechanisms research
- Endometriosis Research and Treatment
- Gynecological conditions and treatments
- Toxin Mechanisms and Immunotoxins
- Polyomavirus and related diseases
- Advances in Oncology and Radiotherapy
- Protein Tyrosine Phosphatases
- Reproductive Health and Contraception
- Chemokine receptors and signaling
- Artificial Intelligence in Healthcare and Education
- Diversity and Career in Medicine
- Adolescent Sexual and Reproductive Health
- Ultrasound and Hyperthermia Applications
- Pituitary Gland Disorders and Treatments
- Tuberous Sclerosis Complex Research
Azienda USL di Bologna
2020-2024
University of Bologna
2018-2024
Policlinico S.Orsola-Malpighi
2018-2023
University of Naples Federico II
2023
Laboratoire des Sciences de l'Ingénieur, de l'Informatique et de l'Imagerie
2020-2021
Institut de Virologie
2021
University of Birmingham
2020-2021
NIHR Birmingham Biomedical Research Centre
2021
Yorkshire Cancer Research
2021
Urology Foundation
2021
To investigate the prognostic value of posttreatment
The optimal number of neoadjuvant chemotherapy cycles in patients with advanced ovarian cancer is still disputed.To evaluate the impact and role cytoreduction on prognosis cancer.Clinical pathological details were examined. Patients evaluated combining chemotherapy-namely, 'interval debulking surgery' after up to four cycles, 'delayed more than therapy.A total 286 included study. Complete no residual peritoneal disease (CC0) was achieved 74 (74%) interval surgery 124 (66.7%) delayed...
Objective The management of vulvar cancer recurrences is complicated by patients’ advanced age and comorbidities. Bleomycin-based electrochemotherapy a potential treatment option in this setting. However, no data on long-term outcomes are available. Therefore, multicenter observational study was designed to evaluate the 5-year results these patients. Methods Data about patients tumor characteristics, cycles, clinical response, follow-up were recorded. Treatment procedures performed according...
Abstract Endometrial cancer (EC) is the most prevalent gynecological in high‐income countries. Its incidence skyrocketing due to increase risk factors such as obesity, which represents a true pandemic. This study aimed evaluate microRNA (miRNA) expression obesity‐related EC identify potential associations between this specific type and obesity. miRNA levels were analyzed 84 patients stratified based on body mass index (BMI; ≥30 or <30) nine noncancer women with The data further tested...
The ELECHTRA (ELEctroChemoTherapy vulvaR cAncer) project was conceived to collect data on palliative electrochemotherapy (ECT) in vulvar cancer (VC) assessing patients’ outcomes (response and survival) impact quality of life (QoL). After reporting outcome 2019, here, we present the results QoL. A multicenter prospective observational study conducted patients with VC refractory or not amenable standard therapies undergoing ECT as per clinical practice. following questionnaires were...
Introduction The Cancer Genome Atlas (TCGA) project identified four distinct prognostic groups in endometrial cancer (EC), among which two are correlated with an intermediate prognosis: the MisMatch Repair-deficient (MMRd) and No Specific Molecular Profile (NSMP) groups. represent a heterogeneous subset of patients frequently harboring CTNNB1 alterations distinctive clinicopathologic features. study aimed to evaluate miRNA expression ECs identify potential biomarkers prognosis. Methods We...
Abstract Purpose Impairment of skeletal muscle mass and strength affects 40–70% patients with active Cushing’s syndrome (CS). Glucocorticoid excess sustains atrophy weakness, while muscle-specific microRNAs (myomiRs) level changes were associated organization function perturbation. The aim the current study is to explore in circulating myomiRs CS compared healthy controls their involvement IGFI/PI3K/Akt/mTOR pathway regulation muscle. Methods C2C12, mouse myocytes, exposed hydrocortisone...
Tumor response in locally advanced cervical cancer (LACC) is generally evaluated with MRI and PET, but this strategy not supported by the literature. Therefore, we compared diagnostic performance of these two techniques evaluation to concurrent chemoradiotherapy (CCRT) LACC. Patients (CC) stage T2b treated CCRT submitted PET/CT before after treatment were enrolled study. All clinical, pathological, therapeutic, radiologic follow-up data collected examined. The radiological was analyzed data....
During the SARS-CoV-2 pandemic, majority of healthcare resources affected Italian regions were allocated to COVID-19 patients. Due lack and high risk death, most cancer patients have been shifted non-surgical treatments. The following reports our experience a Gynaecologic Oncology Unit's reallocation in free surgical oncologic hub order guarantee standard quality activities.
Endometrial cancer is the most common gynecological malignancy of female reproductive organs. Historically it was divided into type I and II, until 2013 when Cancer Genome Atlas molecular classification proposed. Here, we applied different types on our endometrial patient cohort in order to identify predictive one. We enrolled 117 patients available for study collected following parameters: age, body mass index, stage, menopause, Lynch syndrome status, parity, hypertension, localization...
Background: Uterine tumor resembling ovarian sex-cord is an extremely rare uterine mesenchymal neoplasm. Less than 100 cases have been described in literature and only eleven were treated with a fertility sparing approach. Three patients preservation of reproductive function presented local relapse; among these, two conservatively one had second relapse peritoneal carcinomatosis. Case Description: We report the case 24-year-old nulliparous woman presenting abnormal bleeding secondary anemia....
Epithelial Ovarian cancer is the most lethal and silent gynaecological tumor relapses in about 75% of cases.Retrospective data supported superiority secondary cytoreduction surgery (SCS) plus chemotherapy versus alone; order to best select patients for SCS literature established a clinical score based on ascites, performance status, absence residual disease primary surgery.The present study analyzed outcomes pattern relapse population with first ovarian undergoing without divided into two...
Background: Malignant bowel obstruction (MBO) is often the latest stage in ovarian cancer (OC). The therapy of this condition ranges from medical waiting to surgery. objective pilot study compare two strategies so that we can provide a path forward for future studies. Methods: From 700 women diagnosed with OC database Division Gynecologic Oncology crossed names those admitted by emergency services IRCSS Azienda Ospedaliero Universitaria Bologna, Italy. We selected MBO patients history as...
<h3>Objectives</h3> Introduction. The TCGA project identified four distinct prognostic groups of endometrial carcinoma (EC) based on molecular alterations among which two are correlated with an intermediate prognosis: the MisMatch Repair deficient (MMRd) and No Specific Molecular Profile (NSMP) groups. NSMP represents a heterogenous subset patients frequently harboring CTNNB1 presenting distinctive clinicopathologic features comparing non mutant ones. miRNAs oncological key players that have...