A5103209474- Breast Lesions and Carcinomas
- Cancer and Skin Lesions
- Endometrial and Cervical Cancer Treatments
- Colorectal and Anal Carcinomas
- Cell Adhesion Molecules Research
- Circular RNAs in diseases
- Breast Cancer Treatment Studies
- Mycobacterium research and diagnosis
- CNS Lymphoma Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Orthopedic Infections and Treatments
- Bone health and treatments
- Thyroid Cancer Diagnosis and Treatment
- Single-cell and spatial transcriptomics
- Spinal Fractures and Fixation Techniques
- Hematological disorders and diagnostics
- Protease and Inhibitor Mechanisms
- Cancer Cells and Metastasis
- Cancer Genomics and Diagnostics
- Full-Duplex Wireless Communications
- Sinusitis and nasal conditions
- Biliary and Gastrointestinal Fistulas
- Cancer-related Molecular Pathways
- Cutaneous Melanoma Detection and Management
- Vascular Tumors and Angiosarcomas
Azienda USL di Bologna
2021-2023
Istituti di Ricovero e Cura a Carattere Scientifico
2021-2023
Istituto delle Scienze Neurologiche di Bologna
2021
University of Bologna
2016-2021
Ospedale Bellaria
2020
Istituto Ortopedico Rizzoli
1999-2001
Abstract RNA modifications are key regulatory factors for several biological and pathological processes. They abundantly represented on ribosomal (rRNA), where they contribute to regulate function in mRNA translation. Altered modification pathways have been linked tumorigenesis as well other human diseases. In this study we quantitatively evaluated the site-specific pseudouridylation pattern rRNA breast cancer samples exploiting RBS-Seq technique involving bisulfite treatment coupled with a...
The European Society of Gynecologic Oncology/European Radiation Therapy and Pathology (ESGO/ESTRO/ESP) committee recently proposed a new risk stratification system for endometrial carcinoma (EC) patients that incorporates clinicopathologic molecular features. aim the study is to compare ESGO/ESTRO/ESP classification with previous 2016 recommendations, evaluating impact defining algorithm selecting cases analysis assign appropriate class.The cohort included 211 consecutive EC patients....
The BRAF p.V600E mutation represents the most specific marker for papillary thyroid carcinoma and is potentially related to aggressive behavior persistent disease. alterations other than are less common in represent an alternative mechanism of activation with unclear clinical significance. study aims describe frequency clinicopathologic characteristics non-V600E mutations a large cohort (1654 samples) lesions characterized by next-generation sequencing. have been found 20.3% (337/1654)...
The molecular characterization of endometrial carcinoma (EC) has recently been included in the ESGO/ESTRO/ESP guidelines. study aims to evaluate impact integrated and pathologic risk stratification clinical practice relevance parameters predicting prognosis each EC subgroup. ECs were classified using immunohistochemistry next-generation sequencing into four classes: POLE mutant (POLE), mismatch repair deficient (MMRd), p53 (p53abn), no specific profile (NSMP). According WHO algorithm, 219...
Introduction The Cancer Genome Atlas (TCGA) project identified four distinct prognostic groups in endometrial cancer (EC), among which two are correlated with an intermediate prognosis: the MisMatch Repair-deficient (MMRd) and No Specific Molecular Profile (NSMP) groups. represent a heterogeneous subset of patients frequently harboring CTNNB1 alterations distinctive clinicopathologic features. study aimed to evaluate miRNA expression ECs identify potential biomarkers prognosis. Methods We...
Since the Cancer Genome Atlas (TCGA) project identified four distinct groups based on molecular alterations, mutation analyses have been integrated into characterization of endometrial carcinomas (ECs). ARID1A seems to be subunit more involved in loss function SWI/SNF complex ECs. The aim this study is define relevance alterations a cohort EC, studying possible associations between DNA (genomic level), RNA expression (transcriptomic and protein (proteomic level). A total 50 were...
Aims A wide range of post‐radiotherapy (RT) vascular lesions can occur, ranging from benign lymphangiomatous papules the skin (BLAPs), to atypical (AVLs) and post‐RT angiosarcomas (ASs). The relationship between malignant breast their prognostic features are still controversial. aims this study were investigate mammary define AS features. Methods results Seventy‐four lesion cases obtained stained with antibodies against CD34, CD31, D2‐40, Ki67, c‐Myc. Mutational analysis was performed by...
Abstract Merkel cell carcinoma (MCC) is an aggressive skin tumor with neuroendocrine differentiation, mainly affecting elderly population or immunocompromised individuals. As methylation of the human telomerase reverse transcriptase (m hTERT ) has been shown to be a prognostic factor in different tumors, we investigated its role MCC, particular intron 4–5 where rs10069690 mapped and recognized as cancer susceptibility locus. DNA analysis gene was assessed retrospectively cohort 69 MCC...
Abstract Intrahepatic cholangiocarcinoma (iCCA) is a rare malignancy, recently classified in small duct and large morphological subtypes. Growing evidence suggests asbestos as putative risk factor for iCCA, albeit no correlation between iCCA morphology has been investigated so far. The aim of the present study was to assess relationship exposure subtype. Forty patients with surgically removed were prospectively enrolled: assessed according Italian National Mesothelioma Register...
Periprosthetic osteolysis is a major clinical problem in total hip and knee arthroplasty polymethylmethacrylate (PMMA) possible etiologic factor. Recently, increasing importance was ascribed to interleukin-6 (IL-6) as an agent favouring bone resorption. The aim of the present study investigate role cements on IL-6 production by MG63. effect four acrylic (Sulfix-60®, CMW 1®, 2®, 3®) protein release mRNA expression osteoblast-like cell line MG63 examined using IL-1 β (0.2 μg ml-1) positive...
Abstract Carcinomas with apocrine differentiation (CAD) of the breast are rare tumours typically presenting high immunohistochemical expression androgen receptor (AR) which is a target molecule for personalised therapy. To date, no studies have evaluated genetic changes that associated AR in CADs. The present work aims to characterise status Twenty CAD were studied immunohistochemistry, situ fluorescence hybridization and DNA methylation analysis, evaluate its regulator status. All...
We present the case of a 47-year-old man with left exophthalmus. MRI showed intraorbital intraconal cavernous malformation, located in superoesternal quadrant and medially displacing optic nerve. An endoscopic transpalpebral approach was performed total removal achieved after dissection lesion from nerve other orbital structures. Pathology confirmed diagnosis malformation. The patient discharged neurologically intact on second postoperative day free complications. Follow-up demonstrated...
Abstract The production of 6-kcto prosta-landin Flα (6-keto-PGF1α), stable metabolyte prostacyclin, by cultured human endothelial cells in contact with carbon- and collagen-coated polyethylene terephthalate (PC), was assessed enzyme immunoassay. As control material, tissue culture-treated polystyrene used. cultures were put the materials for 48 h then stimulated 0.1 mM arachidonic acid 3 h. stimulation induced a highly signilicant increase 6-keto-PGF 1α material. PC only insignificant...
Introduction: Serrated lesions are a heterogeneous group of routinely evaluated with different morphologic subtypes, and colorectal carcinogenesis has been related to the understanding serrated pathway in these lesions. In this setting, BRAF V600E mutation demonstrated as marker for carcinogenic evolution, while mismatch repair protein (MMR) was recognized small subset hyperplastic polyps. Design: This study aimed evaluate interobserver agreement among 6 pathologists morphological diagnosis...