A5060699731- Sarcoma Diagnosis and Treatment
- Cutaneous Melanoma Detection and Management
- Testicular diseases and treatments
- Immunotherapy and Immune Responses
- Ocular Surface and Contact Lens
- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Corneal Surgery and Treatments
- Cancer Genomics and Diagnostics
- Chromatin Remodeling and Cancer
- Urologic and reproductive health conditions
- Cervical Cancer and HPV Research
- Colorectal and Anal Carcinomas
- Cancer Mechanisms and Therapy
- melanin and skin pigmentation
- Bladder and Urothelial Cancer Treatments
- Infrared Thermography in Medicine
- Cancer, Hypoxia, and Metabolism
- Soft tissue tumor case studies
- Adrenal and Paraganglionic Tumors
- Cellular Mechanics and Interactions
- Cancer Cells and Metastasis
- Cancer Diagnosis and Treatment
- Circular RNAs in diseases
- S100 Proteins and Annexins
Azienda USL di Bologna
2021-2025
Policlinico S.Orsola-Malpighi
2013-2023
University of Bologna
2010-2023
Istituti di Ricovero e Cura a Carattere Scientifico
2023
The collaborative Cancer Genome Atlas (TCGA) project identified four distinct prognostic groups of endometrial carcinoma (EC) based on molecular alterations: (i) the ultramutated subtype that encompasses POLE mutated (POLE) cases; (ii) hypermutated subtype, characterized by MisMatch Repair deficiency (MMRd); (iii) copy-number high with p53 abnormal/mutated features (p53abn); (iv) low known as No Specific Molecular Profile (NSMP). Although value TCGA classification, NSMP carcinomas present a...
PRAME (PReferentially expressed Antigen in MElanoma), a cancer-testis antigen normal and neoplastic tissues with several functions, proved to be useful diagnostic tool the differential diagnosis between benign malignant melanocytic lesions. The current study aims perform stain on retrospective case series of mucosal tumors head neck region compare 3 different scores evaluate most reliable one this set. Immunohistochemical analysis for was performed 54 collected from 41 patients....
The European Society of Gynecologic Oncology/European Radiation Therapy and Pathology (ESGO/ESTRO/ESP) committee recently proposed a new risk stratification system for endometrial carcinoma (EC) patients that incorporates clinicopathologic molecular features. aim the study is to compare ESGO/ESTRO/ESP classification with previous 2016 recommendations, evaluating impact defining algorithm selecting cases analysis assign appropriate class.The cohort included 211 consecutive EC patients....
PRAME ( PR eferentially expressed A ntigen in ME lanoma) is a tumor-associated antigen that was recently found to be by malignant melanocytic lesions but not benign ones, thus resulting useful this diagnostic field. could also some normal tissues and nonmelanocytic tumors, suggesting as caution should adopted use “pan-melanoma” marker for the differential diagnosis with other tumors. Until now, expression exclusively investigated through single staining monoclonal antibody targeting double...
Abstract Ovarian cancer (OC) poses significant treatment challenges due to late-stage diagnosis and a complex tumor microenvironment contributing therapy resistance. We optimized U-CUP perfusion-based bioreactor method culture patient-derived primary metastatic OC specimens, demonstrating that perfusion better preserves cell viability proliferation, both when fresh slow-frozen tissues were used. Perfused cultures maintained key components, including cancer-associated fibroblasts, endothelial...
High-grade serous ovarian carcinoma (HGSOC) is one of the deadliest malignancies in female population and cause 70% all cancer-related deaths. Among its hallmarks, fluid accumulation peritoneal cavity, or ascites, a peculiar pathological sign during late stages recurrent patients. Besides cancer cells, ascitic fluids contain heterogeneous cellular composition, representing precious source to dissect molecular mechanisms underlying invasion metastatization find new biomarkers predict therapy...
Aims Primary mixed liver cancers (PLCs), combined hepatocellular‐cholangiocellular (cHCC‐CC) and intermediate‐cell carcinomas are rare tumours characterised by different molecular mechanisms. Nestin is a marker of progenitor cells with promising application in human tumours. The aims the present paper (i) to determine expression PLCs; (ii) correlate PLC immunoprofile gene each tumour component. Methods results We selected 28 PLCs, 13 (46.4%) cHCC‐CC 15 (53.6%) carcinomas....
Preferentially expressed antigen in melanoma (PRAME) has a key role regulating pluripotency of primordial germ cells and the development cell tumors testis (GCTT). However, its immunohistochemical expression normal testes neoplastic counterpart remain largely unknown.We retrospectively investigated PRAME 26 cases GCTT, 21 neoplasia situ (GCNIS), 17 uninvolved background testes.We found that was more strongly by seminomatous rather than nonseminomatous GCTT (P = .000) pure seminoma component...
Cord blood serum (CBS)-based eye drops are successfully used in corneal epithelial wound healing and prepared to supply a known amount of epidermal growth factor (EGF). Product standardisation includes expensive EGF dosage all cord (CB) units. The influence donor obstetric haematological characteristics on content was evaluated, exclude unsuitable CBS pre-select those CB units able provide the correct for wounds.Data were retrospectively collected from 135 donors included Emilia Romagna...
The molecular characterization of endometrial carcinoma (EC) has recently been included in the ESGO/ESTRO/ESP guidelines. study aims to evaluate impact integrated and pathologic risk stratification clinical practice relevance parameters predicting prognosis each EC subgroup. ECs were classified using immunohistochemistry next-generation sequencing into four classes: POLE mutant (POLE), mismatch repair deficient (MMRd), p53 (p53abn), no specific profile (NSMP). According WHO algorithm, 219...
Since the Cancer Genome Atlas (TCGA) project identified four distinct groups based on molecular alterations, mutation analyses have been integrated into characterization of endometrial carcinomas (ECs). ARID1A seems to be subunit more involved in loss function SWI/SNF complex ECs. The aim this study is define relevance alterations a cohort EC, studying possible associations between DNA (genomic level), RNA expression (transcriptomic and protein (proteomic level). A total 50 were...
A 9-month old male Jack Russell Terrier started showing paraparesis of the hindlimbs after a walk. Hospitalized, dog went into cardiac arrest, and later died. Necroscopic examination revealed severe thickness diaphragm, esophagus, base tongue, leading to diagnosis muscular dystrophy. The histology confirmed marked size variation, regeneration, fibrosis replacement skeletal muscle fibers. Immunohistochemistry demonstrated absence dystrophin confirming diagnosis. Transmission electron...
We have investigated the morphology of sinus node human cardiac conduction system. Until today (SN) is described as a heterogeneous system composed 2 types cells, namely, P or pale and T transitional cells which are immersed in matrix around nodal artery. said to share characteristics peripheral working atrial myocardial cells. This study was carried out on autoptic explanted specimens using histochemical, immunohistochemical, electron microscopic methods. Our investigations show that SN...
One of the most relevant genetic alterations in cutaneous melanoma (CM) is biallelic inactivation/loss-of-heterozygosis (LOH) cyclin-dependent kinase inhibitor 2 A (CDKN2A), which results immunohistochemical loss p16 frequently found CM. However, we recently described a rare case dermal/deep-seated arising giant congenital nevus (DDM-GCN) with overexpression combined p53 and tumor protein 53 (TP53) mutation. Herein, reported series CM analyzed their clinicopathologic features, expression...