A5017865594- Cancer Genomics and Diagnostics
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Pancreatic and Hepatic Oncology Research
- Cutaneous Melanoma Detection and Management
- Cancer and Skin Lesions
- Genetic and rare skin diseases.
- Liver Disease Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Ear and Head Tumors
- Tumors and Oncological Cases
- Nonmelanoma Skin Cancer Studies
- Pediatric Hepatobiliary Diseases and Treatments
- Liver physiology and pathology
- Salivary Gland Tumors Diagnosis and Treatment
- CAR-T cell therapy research
Azienda USL di Bologna
2023-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2023-2025
University of Bologna
2021-2024
Policlinico S.Orsola-Malpighi
2022
Combined hepatocellular-cholangiocarcinoma (cHCC-CCA) is a rare primary liver cancer, with intermediate biological characteristics between hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA). Given its rarity the lack of robust data from randomized clinical trials, treatment not standardized, choice on how to best manage disease left expertise each institution. In metastatic setting, given more aggressive behavior CCA component, usual approach start chemotherapy instead...
Fabry disease (FD) is a rare X-linked lysosomal storage disorder caused by mutations in the GLA gene, leading to α-galactosidase A deficiency and subsequent accumulation of glycosphingolipids, including globotriaosylceramide (Gb3) globotriaosylsphingosine (lyso-Gb3), multiple organs. This can result multisystemic life-threatening complications. FD presents with broad phenotypic spectrum, ranging from classic form, early severe symptoms, later-onset form variable manifestations. The severity...
To analyze the diagnostic accuracy and feasibility of digital-PCR (dPCR) combined with next-generation sequencing (NGS) in ERCP-guided histological diagnosis biliary strictures to overcome issue represented by scarcity sampled material. Twenty-two prospective patients were included, submitted ERPC-guided biopsy or resection. By histopathological analysis plus fluorescence situ hybridization (FISH) for chromosomes 3, 7, 17 aneuploidies, 8 cases (36.4%) malignant, 14 (63.6%) negative. NGS was...
Abstract Surgical resection for hepatocellular carcinoma (HCC) is burdened with a high recurrence rate and lack of reliable prognostic factors. The aim this study was to integrate the HCC pathological features gene mutations improve role analysis. This monocentric prospective study, including 67 patients resected HCC. All clinical data histological were collected, tumor grade, architecture, margins, microvascular invasion, microscopic portal vascular invasion (MPVI). Next-generation...
Introduction: The progressive technologies in albumin situ hybridization (ISH) changed the routine application and differential diagnosis of hepatic malignancies last years. aim present work was to assess diagnostic utility ISH on different cholangiocarcinoma (CCA) subtypes, as well how production changes along biliary tree. Methods: Forty-five CCAs were retrospectively selected: 29 intrahepatic (15 small-duct 14 large-duct subtypes), 7 perihilar, 9 extrahepatic. Histology revised all cases,...
article: Giant (pseudo) vascular spiradenoma: a case report of an extremely rare entity with the immuno-histological demonstration coexistence and pseudo-vascular components - Italian Journal Dermatology Venereology 2021 October;156(5):630-2 Minerva Medica Journals