A5030248449- Sexual Differentiation and Disorders
- Sperm and Testicular Function
- Reproductive Biology and Fertility
- Ovarian function and disorders
- Sexual function and dysfunction studies
- Reproductive Health and Technologies
- Male Reproductive Health Studies
- Testicular diseases and treatments
- Growth Hormone and Insulin-like Growth Factors
- Effects and risks of endocrine disrupting chemicals
- Pituitary Gland Disorders and Treatments
- Epigenetics and DNA Methylation
- Urological Disorders and Treatments
- Adrenal and Paraganglionic Tumors
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Islamic Studies and History
- LGBTQ Health, Identity, and Policy
- Dermatology and Skin Diseases
- Hormonal Regulation and Hypertension
- Toxic Organic Pollutants Impact
- Hair Growth and Disorders
- Hormonal and reproductive studies
- Italian Social Issues and Migration
- Global Political and Social Dynamics
Sapienza University of Rome
2016-2023
Bambino Gesù Children's Hospital
2023
University of L'Aquila
2022
Varicocele is a vascular disease characterised by the abnormal enlargement of pampiniform plexus veins and well-known cause male infertility. The aim this study was to investigate relationship between sperm DNA fragmentation (SDF) inflammation in pathogenesis varicocele. We included 84 varicocele patients 85 normozoospermic healthy controls, further analysed according body mass index, smoking habit (smokers/non-smokers) severity (low/high grade). Semen parameters, SDF (by TUNEL) inflammatory...
The diagnosis of testicular cancer (TC) can have a considerable and persistent impact on patient's sexuality, especially given its location. high prevalence TC in young adults, the good prognosis, explain great interest sexual dysfunction influence post-treatment quality life. aim this study was to evaluate treatments (inguinal orchiectomy chemotherapy) sex For purpose, we recruited 241 patients attending Laboratory Seminology –Sperm Bank "Loredana Gandini" for sperm cryopreservation (mean...
The management of male idiopathic infertility is heterogeneous. Although meta-analyses reported the effectiveness on pregnancy rate, real clinical impact follicle-stimulating hormone (FSH) was not evaluated so far. In Italy, FSH approved by National Medicines Agency (AIFA) for infertile patients with < 8 IU/L, independently semen parameters.Primary endpoint to record therapeutic approach partner couples. Secondary aim assess changes parameters during treatment.A multicentre, prospective,...
This study aims to evaluate genetic contribution and sperm DNA fragmentation (SDF) in a cohort of 18 unrelated globozoospermic Italian men (Group G). Semen samples were assessed according the WHO 2010 Laboratory Manual compared with 31 fertile controls. We focused our analysis on exons main globozoospermia-associated genes, performing qualitative PCR assess deletion DPY19L2 sequencing detect mutations SPATA16 PICK1. SDF was evaluated using TUNEL assay. In Group G, 10 patients had complete...
Virilization of gender-incongruent subjects to whom were assigned the female gender at birth (AFAB) is achieved through testosterone administration. Inter-individual differences in timing and acquisition phenotypic characteristics, even if same hormone preparations regimens are used, frequently observed. Polymorphisms sex receptors methylation their gene promoters, as well several imprinted genes H19, may underlie differential response treatment. Thus, aim this study was examine possible...
Abstract Background Sellar/parasellar lesions have been studied in the adult and paediatric age range, but during transition their epidemiology, clinical manifestations, management treatment outcomes poorly investigated. Materials methods An Italian multicentre cohort study, which hospital records of patients with diagnosis sellar/parasellar young adulthood (15–25 years), were reviewed terms prevalence, hormonal features at diagnosis, where available. Both pituitary neuroendocrine tumours...
After a huge decline in sperm concentration between 1938 and 1991 was reported, many researchers investigated the possibility of worsening human quality. Despite massive efforts, published evidence is still controversial. Similarly, role lifestyle factors on semen parameters debated. We conducted monocentric Italian study to evaluate total number trend over last 10 years (from 2010 2019). Additionally, we evaluated association order identify possible damaging factors. performed retrospective...
As myo-inositol (MI) deficiency has been associated with impaired sperm quality, we aimed to assess its effects on kinetics objectively, using a computer-aided analysis (CASA) system.We evaluated 59 normokinetic semen samples nonlinear progressive motility before and after incubation solution of MI. The were collected from healthy subjects aged 20-40 years who attending our Laboratory Seminology for fertility screening.We found significant increase in linear (28.2% ± 10.8 vs. 30.9% 11.0, T0...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)