A5004046389- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Sexual Differentiation and Disorders
- Sperm and Testicular Function
- Hormonal and reproductive studies
- Hypothalamic control of reproductive hormones
- Growth Hormone and Insulin-like Growth Factors
- Ovarian function and disorders
- Reproductive Biology and Fertility
- Genetic Syndromes and Imprinting
- Prenatal Screening and Diagnostics
- Celiac Disease Research and Management
- Birth, Development, and Health
- Pharmacology and Obesity Treatment
- RNA regulation and disease
- Childhood Cancer Survivors' Quality of Life
- Lipid metabolism and disorders
- Pancreatic function and diabetes
- melanin and skin pigmentation
- Urticaria and Related Conditions
- Genetic Neurodegenerative Diseases
- Sexual function and dysfunction studies
- Nutrition and Health in Aging
- Diabetes and associated disorders
- Hormonal Regulation and Hypertension
- Thyroid Disorders and Treatments
Sapienza University of Rome
2013-2023
Policlinico Umberto I
2010-2021
Università Campus Bio-Medico
2009
Summary Background Hypogonadism in Prader–Willi syndrome (PWS) is generally attributed to hypothalamic dysfunction or primary gonadal defect, but pathophysiology still unclear. Objectives To investigate the aetiology of hypothalamic–pituitary–gonadal axis PWS males. Methods Clinical examination and blood sampling for luteinizing hormone (LH), follicle‐stimulating (FSH), testosterone, inhibin B sexhormone–binding globulin (SHBG) were performed 34 patients, age 5·1–42·7 years, 125 healthy...
In adult men, inhibin B (InhB) regulates FSH secretion by a negative feedback. The aims of this study were to evaluate the changes InhB during puberty in male and relationship between FSH, LH, testosterone testicular volume.Cross-sectional study.InhB was measured using two-site ELISA 100 healthy boys subdivided their pubertal development according Tanner into five groups 20.During we observed an increase level (G1 = 84.3 pg/ml, G3 132.2 G5 206.1 pg/ml). G1, correlated positively with (P...
Klinefelter syndrome is the most common chromosomal disorder in males and cause of hypergonadotropic hypogonadism. We describe natural history testicular dysfunction patients with through integration clinical, hormonal, quantitative ultrasound data a life-course perspective.Prospective semilongitudinal study.We included 155 subjects 47,XXY karyotype (age range: 7 months-55 years) naïve to testosterone replacement therapy. Subjects were divided according pubertal stage age group (transition...
Klinefelter syndrome (KS) is the most common sex chromosome aneuploidy in males. As well as classic KS, less frequent higher-grade aneuploidies (HGAs) are also possible. While KS and HGAs both involve testicular dysgenesis with hypergonadotropic hypogonadism, they differ many clinical features. The aim of this study was to investigate endocrinal metabolic differences between HGAs.Cross-sectional, case-control study.88 patients 24 an HGA 60 healthy controls. Given known age-related all...
Testosterone (T) exerts different effects on the cardiovascular system. Despite this knowledge, acute vascular effect of androgen remains still poorly understood.We investigated T function in ten men (18-40 years age) with hypogonadism and severe hypotestosteronemia [serum total testosterone (TT) = 0.6 ± 0.3 ng/mL]. In a 4-day double-blind, randomized, placebo-controlled crossover study, we administered 80 mg daily dose transdermal-T gel (TG) evaluated endothelial variations Endopat2000...
The diagnosis of testicular cancer (TC) can have a considerable and persistent impact on patient's sexuality, especially given its location. high prevalence TC in young adults, the good prognosis, explain great interest sexual dysfunction influence post-treatment quality life. aim this study was to evaluate treatments (inguinal orchiectomy chemotherapy) sex For purpose, we recruited 241 patients attending Laboratory Seminology –Sperm Bank "Loredana Gandini" for sperm cryopreservation (mean...