A5060965051- Census and Population Estimation
- Cardiovascular Function and Risk Factors
- Heart Failure Treatment and Management
- Systemic Sclerosis and Related Diseases
- Migration, Health and Trauma
- Statistical Methods and Bayesian Inference
- Cardiac Imaging and Diagnostics
- Neurological disorders and treatments
- Data-Driven Disease Surveillance
- Cardiovascular Health and Disease Prevention
- Cardiovascular Effects of Exercise
- Blood Pressure and Hypertension Studies
- Corneal Surgery and Treatments
- Eosinophilic Disorders and Syndromes
- Corneal surgery and disorders
- Chronic Myeloid Leukemia Treatments
- Sepsis Diagnosis and Treatment
- Wildlife Ecology and Conservation
- Cardiac Arrhythmias and Treatments
- Genetic Neurodegenerative Diseases
- Cardiac electrophysiology and arrhythmias
- COVID-19 epidemiological studies
- Streptococcal Infections and Treatments
- Migraine and Headache Studies
- Chronic Lymphocytic Leukemia Research
Sapienza University of Rome
2015-2024
Link Campus University
2024
Policlinico Umberto I
2017-2023
Ospedale Santa Maria Goretti
2023
Istituto Pasteur
2018
Many neurophysiological abnormalities have been described in the primary motor cortex of patients with Parkinson's disease. However, it is unclear whether there any relationship between them and bradykinesia, one cardinal features condition. In present study we aimed to investigate objective measures bradykinesia disease as assessed by means transcranial magnetic stimulation techniques. Twenty-two 18 healthy subjects were enrolled. Objective measurements repetitive finger tapping (amplitude,...
BACKGROUND Prediction of difficult mask ventilation (DMV) is as challenging laryngoscopy. Ultrasound could be a helpful tool in the prediction these difficulties. OBJECTIVES The purpose this study was to evaluate ability pre-operative ultrasound assessment neck anatomy predicting DMV and laryngoscopy patients undergoing during elective surgery requiring tracheal intubation. DESIGN Prospective, single blind, observational study. SETTING Operating theatre teaching hospital Italy from April...
Objective: To identify risk and protective factors for mental health symptoms associated with lifestyle changes caused by home confinement in pediatric subjects children adolescents a neuropsychiatric disorder. Study design: This was prospective, cross-sectional study conducted from May 10 to 31, 2020. Two online anonymous surveys were developed: population-based clinical-based (children disorders). Outcomes included emotional behavioral symptoms, as assessed psychometric scales (BPSC, PPSC,...
Abstract Evidences of an association between air pollution and Covid-19 infections are mixed inconclusive. We conducted ecological analysis at regional scale long-term exposure to air-borne particle matter spread cases during the first wave epidemics. Global climate data were calculated from satellite earth observation assimilated into numerical models 10 km resolution. Main outcome was defined as cumulative number in 14 days following date when > reported. Negative binomial effect...
Abstract Essential tremor (ET) is a heterogeneous disorder characterized by bilateral upper limbs action and, possibly, neurological signs of uncertain significance, including voluntary movement abnormalities and cognitive disturbances, i.e., the so-called ‘soft’ configuring ET-plus definition. While motor disturbances often coexist in ET, their interrelationship remains largely unexplored. Here we aim to further investigate relationship between symptoms, objectively assessed through...
Abstract Introduction The gut microbiota is involved in the regulation of cognition, mood, anxiety, and pain, can impact cognitive functions by producing neuroactive substances or releasing bacterial by‐products metabolites. No information available on effects a probiotic supplementation brain function HIV + subjects. In light above considerations, we performed pilot study cART ‐treated ‐1‐positive patients with long‐term virologic suppression. aims were to analyze effect high‐concentration...
Background: The introduction of the diagnosis complex posttraumatic stress disorder (CPTSD) by ICD-11 is a turning point in field traumatic studies. It's therefore important to examine validity CPTSD refugee groups exposed trauma (CT) defined as repeated, prolonged, interpersonal event.Objective: objective this study was compare DSM-5 and post-traumatic diagnoses evaluate discriminant PTSD constructs sample treatment-seeking refugees living Italy.Method: included 120 African Italy. All...
In 2022, three antiviral drugs—molnupiravir, remdesivir and nirmatrelvir/ritonavir—were introduced for treatment of mild-to-moderate COVID-19 in high-risk patients. The aim this study is the evaluation their effectiveness tolerability a real-life setting. A single-center observational was set up, with involvement 1118 patients, complete follow-up data, treated between 5th January 3rd October 2022 at Santa Maria Goretti’s hospital Latina, Central Italy. univariable multivariable analysis were...
Bradykinesia is the hallmark feature of Parkinson's disease (PD); however, it can manifest in other conditions, including essential tremor (ET), and healthy elderly individuals.Here we assessed whether bradykinesia features aid distinguishing PD, ET, individuals.We conducted simultaneous video kinematic recordings finger tapping 44 PD patients, 69 ET 77 individuals. Videos were evaluated blindly by expert neurologists. Kinematic analyzed. We calculated inter-raters agreement compared data...
Patients with acute SARS-CoV-2 and pre-existing oncohematological conditions challenge clinicians due to a heightened risk for severe COVID-19 forced deferral of cancer treatment. Different treatment approaches aim either prevent the progression mild disease (“early therapy”) or treat more COVID-19. Currently, there is limited evidence supporting effectiveness tailored approach patients. We present real-world experience from two university hospitals. In this retrospective study we recruited...
Background and purpose Essential tremor (ET) is a movement disorder primarily characterized by upper limb postural kinetic tremor. Although still under‐investigated, bradykinesia may be part of the phenotypic spectrum ET. The aim was to evaluate features in ET through clinical examination kinematic analysis repetitive finger movements. Data collected patients were compared with those recorded Parkinson’s disease healthy controls. Methods Overall, 258 subjects participated study (90 patients,...
Influenza virus replicates intracellularly exploiting several pathways involved in the regulation of host responses. The outcome and severity infection are thus strongly conditioned by multiple factors, including age, sex, metabolic, redox conditions target cells. Hormones also important determinants immune responses to influenza recently proposed prophylaxis treatment. This study shows that female mice less susceptible than males mouse-adapted (A/PR8/H1N1). Compared with males, PR8-infected...
Despite therapeutic improvement, the prognosis of chronic heart failure (CHF) remains unfavorable partly due to arrhythmia and sudden cardiac death (SCD). This prospective study evaluated myocardial 123I-meta-iodobenzylguanidine (123I-mIBG) scintigraphy as a predictor arrhythmic events (AE) in CHF patients. 170 patients referred for implantable cardioverter-defibrillator (ICD) implantation both primary secondary prevention were enrolled. All underwent planar SPECT imaging. Early late...
Purpose To estimate the prevalence of keratoconus in a population subjects undergoing first eye examination an clinic Italy. Methods A single-center, cross-sectional, study was conducted involving patients who underwent at Rome between September 2021 and June 2022. The determined by Placido-disk corneal topography using maximum keratometry (K max ) value Cone Magnitude Location Index (CLMI) for screening. Subjective analysis performed two experienced specialists, classified outcome into...
Despite the empirical and clinical relevance of understanding posttraumatic stress disorder (PTSD) heterogeneity in refugees asylum-seekers, very few studies have examined manner which PTSD symptoms manifest such populations.This study sought to investigate patterns predictors DSM-5 a treatment-seeking sample African refugees.Participants were 122 asylum-seekers living Italy who completed measures trauma exposure symptoms. Latent class analysis (LCA) was used identify symptom profiles,...
Abstract Phlebotonics’ effects were evaluated to reduce time-to-stop bleeding and anal irritation in 130 patients who complained of hemorrhoidal disease (HD); pain after hemorrhoidectomy (31 patients) thrombosis (34 the short time. Sixty randomized receive routine treatment (both conservative surgical) (control Group C). The treated group was divided into two subgroups: one with flavonoids (Group A, n = 73), other Centella B, 66). Time-to-stop checked at baseline checkups (0 up day 42)....
Carbapenem-resistant Klebsiella pneumoniae (CR-Kp) and Acinetobacter baumannii (CR-Ab) represent important cause of severe infections in intensive care unit (ICU) patients. N-Acetylcysteine (NAC) is a mucolytic agent with antioxidant anti-inflammatory properties, showing also in-vitro antibacterial activity. Aim was to evaluate the effect on 30-day mortality addition intravenous NAC antibiotics ICU patients CR-Kp or CR-Ab septic shock. A retrospective, observational case:control study (1:2)...
Gastrointestinal tract (GIT) involvement is frequently observed in systemic sclerosis (SSc) and may lead to nutritional impairment. The aim of the study was assess prevalence symptoms related GIT analyze possible association between gastrointestinal low muscularity SSc patients.Sixty-nine consecutive patients (60 females, median age 53 (IQR 43-63), body mass index (BMI) 23.2 20.9-24.6) kg/m2) with diagnosis admitted our Scleroderma Unit were enrolled. Clinical status, anthropometric data,...
The multi-systemic effects of heart failure (HF) resemble the spread observed during cancer. We propose a new score, named HLM, analogous to TNM classification used in oncology, assess prognosis HF. HLM refers H: damage, L: lung involvement, and M: systemic multiorgan involvement. aim was compare score conventional New York Heart Association (NYHA) classification, American College Cardiology/American (ACC/AHA) stages, left ventricular ejection fraction (LVEF), most accurate prognostic tool...