A5101800415- Amino Acid Enzymes and Metabolism
- Metabolism and Genetic Disorders
- Biochemical effects in animals
- Mosquito-borne diseases and control
- Biomedical Research and Pathophysiology
- Hemoglobinopathies and Related Disorders
- Neonatal Health and Biochemistry
- Malaria Research and Control
- Molecular Sensors and Ion Detection
- Selenium in Biological Systems
- Sulfur Compounds in Biology
- Alzheimer's disease research and treatments
- Iron Metabolism and Disorders
- Genetic diversity and population structure
- Drug Transport and Resistance Mechanisms
- Cholinesterase and Neurodegenerative Diseases
- Amyotrophic Lateral Sclerosis Research
- Metal complexes synthesis and properties
- Polyamine Metabolism and Applications
- Hemoglobin structure and function
- Parkinson's Disease Mechanisms and Treatments
- Folate and B Vitamins Research
- Date Palm Research Studies
- Diet, Metabolism, and Disease
- Species Distribution and Climate Change
Sapienza University of Rome
1975-2024
Istituto Pasteur
2020-2024
Istituto di Chimica Biomolecolare
1981-1982
University of Cagliari
1975
University of Modena and Reggio Emilia
1963
Laboratoire de Chimie
1957
Huntington disease (HD) is a hereditary neurodegenerative disorder characterized by motor, psychiatric, and cognitive symptoms. The genetic defect responsible for the onset of disease, expansion CAG repeats in exon 1 gene that codes huntingtin on chromosome 4, has been unambiguously identified. On other hand, mechanisms which mutation causes are not completely understood yet. However, defects energy metabolism affected cells may cause oxidative damage, proposed as one underlying molecular...
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the deposition of amyloid-beta peptide (Aβ), that as both oligomers and fibrils believed to play central role in development progress AD inducing oxidative stress brain. Therefore, treatment with antioxidants might, principle, prevent propagation tissue damage neurological dysfunction. The aim present study was investigate vivo protective effect antioxidant compound ferulic acid ethyl ester (FAEE) against Aβ-induced on...
Abstract Evidences of an association between air pollution and Covid-19 infections are mixed inconclusive. We conducted ecological analysis at regional scale long-term exposure to air-borne particle matter spread cases during the first wave epidemics. Global climate data were calculated from satellite earth observation assimilated into numerical models 10 km resolution. Main outcome was defined as cumulative number in 14 days following date when > reported. Negative binomial effect...
The enzyme oxidizing cysteamine to hypotaurine has been extracted from horse kidney and purified.The final product behaves as a single protein when analyzed in the ultracentrifuge, by starch gel electrophoresis, filtration on dextran gels.The sedimentation coefficient of pure is s2o, = 5.9.The molecular weight determined Yphantis procedure ( 22) 83,000.Nonheme iron contained amount 1 atom per molecule enzyme.Spectrophotometric analyses indicate absence nonprotein chromophores visible near...
Abstract Increasing evidence suggests a critical role for oxidative and nitrosative stress in the pathogenesis of most important neurodegenerative disorders. Parkinson’s disease (PD) is characterized by severe depletion number dopaminergic cells substantia nigra (SN). Administration L‐DOPA (LD) more effective treatment patients with PD. However, vast majority suffer LD‐related complications, which represent major problem clinical management In present study, LD administration to rats...
Although the ability of animal tissues to oxidize thiols and organic disulfides sulfinates sulfonates has long been recognized, enzymatic mechanism this oxidation is obscure. For extensive literature on field reader referred recent reviews (1, 2). An enzyme capable oxidizing cysteamine (RSH) hypotaurine (R-S02H) thiotaurine (R-SOaH), in presence inorganic forms sulfur, however, recently detected a number (3-6). The elementary sulfur or sulfide was found essential for activity enzyme, it...
The two main Afrotropical malaria vectors - Anopheles coluzzii and An. gambiae are genetically distinct reproductively isolated across West Africa. However, populations at the western extreme of their range assigned as "intermediate" between species by whole genome sequence (WGS) data, hybrid forms conventional molecular diagnostics. By exploiting WGS data from 1190 specimens collected west Africa via 1000 Genomes network, we identified a putative taxon in far-west (provisionally named...
Mosquitoes represent a considerable nuisance and are actual/potential vectors of human diseases in Europe. Costly labour-intensive entomological monitoring is needed to correct planning interventions aimed at reducing the risk pathogen transmission. The widespread availability mobile phones massive Internet connections opens way contribution citizen complementing monitoring. ZanzaMapp first “mosquito” application for smartphones specifically designed assess citizens’ perception mosquito...
<title>Abstract</title> The two main Afrotropical malaria vectors - Anopheles coluzzii and An. gambiae – are genetically distinct reproductively isolated across West Africa. However, populations at the western extreme of their range assigned as “intermediate” between species by whole genome sequence (WGS) data, hybrid forms conventional molecular diagnostics. By exploiting WGS data from 1,190 specimens collected west Africa via 1000 Genomes network, we identify a novel putative taxon in...
Abstract Pyrethroids, targeting the voltage gated sodium channel (VGSC), are fundamental for control of arboviral disease circulation. The spread pyrethroid resistance among vector species represents thus a major public health concern. Culex pipiens is one most abundant European mosquito and main West Nile virus, leading cause encephalitis worldwide. Despite this, monitoring its status understanding underlying mechanisms widely neglected. Herein, we performed an oligo-hybridization capture...
The two most efficient and recently radiated Afrotropical vectors of human malaria - Anopheles coluzzii An. gambiae are identified by single-locus diagnostic PCR assays based on species-specific markers in a 4 Mb region chromosome-X centromere. Inherently, these cannot detect interspecific autosomal admixture shown to be extensive at the westernmost easternmost extremes species range. main aim this study was develop novel, easy-to-implement tools for genotyping gambiae-specific ancestral...
Abstract The mosquito Aedes albopictus transmits human viruses including dengue and chikungunya is an extremely successful invasive species expanding into new regions of the world. New tools are needed to complement existing help monitor control this species. Genomic resources improving for genome reference sequences, whole sequencing data will catalog genetic diversity in further enable analysis. We collected populations Ae. from throughout its distribution generated population samples....