A5028683177- Malaria Research and Control
- Mosquito-borne diseases and control
- Insect Resistance and Genetics
- Insect and Pesticide Research
- Pesticide Residue Analysis and Safety
- Invertebrate Immune Response Mechanisms
- Viral Infections and Vectors
- Pharmacological Effects and Assays
- Parasites and Host Interactions
- Genetic diversity and population structure
- Date Palm Research Studies
- Insect Pest Control Strategies
- Agricultural pest management studies
- Pesticide Exposure and Toxicity
Njala University
2025
Abt Associates (Nepal)
2021-2024
Schulman, Ronca & Bucuvalas
2024
U.S. President's Malaria Initiative
2024
MRC Unit the Gambia
2016-2024
Vector (United States)
2021
Aga Khan Hospital, Kisumu
2021
Medical Research Council
2015
As indicators of burden malaria have substantially decreased in The Gambia, reaching a pre-elimination status may be attainable. Achieving this goal requires in-depth understanding the current Plasmodium falciparum infection. A nationwide cross-sectional survey was conducted 2012 to determine prevalence P. infection, and describe its heterogeneity associated risk factors. Finger-prick blood samples were collected for microscopy, species-specific PCR haemoglobin measurement. total 9,094...
Abstract Background Information on the status of insecticide resistance in malaria vectors is critical for implementing effective vector control. The Sierra Leone National Malaria Control Programme, collaboration with PMI VectorLink project, assessed to insecticides commonly used public health, and associated mechanisms Anopheles gambiae , main Leone. Methods susceptibility An. against pyrethroids without piperonyl butoxide (PBO), chlorfenapyr, clothianidin, bendiocarb pirimiphos-methyl was...
Malaria hotspots, areas with consistently higher than average transmission, may become increasingly common as malaria declines. This phenomenon, currently observed in The Gambia, be caused by several factors, including some related to the local vectors, whose contribution is poorly understood. Using WHO susceptibility bioassays, insecticide resistance status was determined vector populations sampled from six pairs of villages across each pair contained a low and high prevalence village....
Following agricultural use and large-scale distribution of insecticide-treated nets (ITNs), malaria vector resistance to pyrethroids is widespread in sub-Saharan Africa. Interceptor® G2 a new dual active ingredient (AI) ITN treated with alpha-cypermethrin chlorfenapyr for the control pyrethroid-resistant vectors. In anticipation these being more widely distributed, testing was conducted develop susceptibility bioassay protocol gather information.Bottle tests were using five concentrations at...
The two main Afrotropical malaria vectors - Anopheles coluzzii and An. gambiae are genetically distinct reproductively isolated across West Africa. However, populations at the western extreme of their range assigned as "intermediate" between species by whole genome sequence (WGS) data, hybrid forms conventional molecular diagnostics. By exploiting WGS data from 1190 specimens collected west Africa via 1000 Genomes network, we identified a putative taxon in far-west (provisionally named...
Abstract Introduction Longitudinal monitoring of outdoor-biting malaria vector populations is becoming increasingly important in understanding the dynamics residual transmission. However, human landing catch (HLC), gold standard for measuring biting rates indoors and outdoors, costly raises ethical concerns related to increased risk infectious bites among collectors. Consequently, routine data on outdoor-feeding mosquito are usually limited because lack a scalable tool with similar...
Vector control activities, namely long-lasting insecticidal nets (LLIN) and indoor residual spraying (IRS), have contributed significantly to the decreasing malaria burden observed in The Gambia since 2008. Nevertheless, insecticide resistance may threaten such success; it is important regularly assess susceptibility of local vectors available insecticides. In transmission seasons 2016 2017, Anopheles gambiae (s.l.) larvae were sampled or around nine vector surveillance sentinel sites...
Abstract Malaria remains a major health problem and vector control is an essential approach to decrease its burden, although it threatened by insecticide resistance. New approaches for are needed. The females of Anopheles gambiae s.l. mate once in their life the swarms formed males. Trapping males potential new intervention control, alternative use insecticides, as would disrupt mating . proof-of-concept pilot study aiming at investigating swarm trapping intervention, was carried out 6...
Abstract Background Thioester-containing protein 1 (TEP1) is a highly polymorphic gene playing an important role in mosquito immunity to parasite development and associated with Anopheles gambiae vectorial competence. Allelic variations TEP1 could render either susceptible or resistant infection. Despite reports of genetic An. , the correlation between allelic variants transmission patterns malaria endemic settings remains unclear. Methods were characterized by PCR from archived genomic DNA...
<title>Abstract</title> Background Information on the status of insecticide resistance in malaria vectors is critical for implementing effective vector control. The Sierra Leone National Malaria Control Program, collaboration with PMI VectorLink project, assessed to insecticides commonly used public health, and associated mechanisms <italic>Anopheles gambiae</italic> s.l., main Leone. Methods susceptibility <italic>An. s.l. against pyrethroids without piperonyl butoxide (PBO), chlorfenapyr,...
Over the last ten years, malaria control using insecticides impregnated bed nets (ITNs) or sprayed on walls during indoor residual spraying has reduced cases and deaths. However, mosquitoes have become resistant to some thereby threatening gains already made. Importantly, how insecticide resistance will affect elimination is poorly understood it’s not clear whether persistence of in countries due sub-optimal use other measures. This study proposes new ways measure role transmission. First,...
Abstract Background Thioester-containing Protein 1 (TEP1) is a highly polymorphic gene playing an important role in mosquito immunity to parasite development and associated with Anopheles gambiae sensu lato ( s.l. ) vectorial competence. Allelic variations TEP1 could render either susceptible or resistant infection. Despite reports of genetic An. , the correlation between allelic variants transmission patterns malaria endemic settings remains unclear. Methods were characterised by PCR from...
Abstract Background Following agricultural use and large-scale distribution of insecticide treated nets (ITNs), malaria vector resistance to pyrethroids is widespread in sub-Saharan Africa. Interceptor® G2 a new dual active ingredient (AI) ITN with alpha-cypermethrin chlorfenapyr for the control pyrethroid-resistant vectors. In anticipation these being more widely distributed, testing was conducted develop susceptibility bioassay protocol gather information. Methods Bottle tests were using...