A5111913281- Alzheimer's disease research and treatments
- Biochemical effects in animals
- Mitochondrial Function and Pathology
- Cholinesterase and Neurodegenerative Diseases
- S100 Proteins and Annexins
- Redox biology and oxidative stress
- Genomics, phytochemicals, and oxidative stress
- Neuroinflammation and Neurodegeneration Mechanisms
- Nanoparticles: synthesis and applications
- Heme Oxygenase-1 and Carbon Monoxide
- 14-3-3 protein interactions
- Advanced Nanomaterials in Catalysis
- Cancer-related cognitive impairment studies
- Metabolomics and Mass Spectrometry Studies
- Neuroscience and Neuropharmacology Research
- Signaling Pathways in Disease
- Biochemical Acid Research Studies
- Tryptophan and brain disorders
- Endoplasmic Reticulum Stress and Disease
- Advanced Glycation End Products research
- Chemotherapy-induced cardiotoxicity and mitigation
- Amino Acid Enzymes and Metabolism
- Brain Metastases and Treatment
- Advanced Proteomics Techniques and Applications
- Sulfur Compounds in Biology
Jagannath University
2025
The University of Texas at Dallas
2024
University College London
2023
University of Pavia
2023
University of Kentucky
2008-2020
Genomics England
2020
The University of Texas Southwestern Medical Center
2016
Markey Cancer Center
2012
Division of Chemistry
2011
University of Louisville
2008-2010
Cerebellar ataxia, neuropathy and vestibular areflexia syndrome (CANVAS) is an autosomal recessive neurodegenerative disease, usually caused by biallelic AAGGG repeat expansions in RFC1. In this study, we leveraged whole genome sequencing data from nearly 10 000 individuals recruited within the Genomics England project to investigate normal pathogenic variation of RFC1 repeat. We identified three novel motifs, AGGGC (n = 6 five families), AAGGC 2 one family) AGAGG 1), associated with CANVAS...
Abstract Alzheimer's disease (AD) is neuropathologically characterized by depositions of extracellular amyloid and intracellular neurofibrillary tangles, associated with loss neurons in the brain. Amyloid β‐peptide (Aβ) major component senile plaques considered to have a causal role development progress AD. Several lines evidence suggest that enhanced oxidative stress inflammation play important roles pathogenesis or progression The present study aimed investigate protective effects...
Alzheimer's disease (AD) is characterized by the presence of intracellular neurofibrillary tangles (NFT), extracellular senile plaques (SP), and synaptic loss. The hippocampus a region that plays an important role in memory cognitive function, it severely affected AD. levels proteins may provide better understanding pathological changes known. In present study we used two-dimensional gel electrophoresis mass spectrometry techniques to determine protein AD control hippocampus. We identified...
Alzheimer's disease (AD) is a neurodegenerative disorder with cognitive and memory decline, personality changes, synapse loss. Increasing evidence indicates that factors such as oxidative nitrosative stress, glutathione depletion, impaired protein metabolism can interact in vicious cycle, which central to AD pathogenesis. In the present study, we demonstrate brains of patients undergo changes classically associated strong induction so-called vitagenes, including heat shock proteins (HSPs)...
Numerous studies have shown that neuronal lipids are highly susceptible to oxidative stress including in those brain areas directly involved the neurodegenerative process of Alzheimer's disease (AD). Lipid peroxidation damages membranes and also generates a number secondary biologically active products (toxic aldehydes)that capable easily attacking lipids, proteins, DNA. Accumulating evidence has demonstrated regionally increased lipid patients with AD; however, extensive on specific targets...
Abstract Adriamycin (ADR), a potent anti‐tumor agent, produces reactive oxygen species (ROS) in cardiac tissue. Treatment with ADR is dose‐limited by cardiotoxicity. However, the effect of other tissues, including brain, unclear because does not pass blood–brain barrier. Some cancer patients receiving treatment develop transient memory loss, inability to handle complex tasks etc., often referred as chemobrain. We previously demonstrated that causes CNS toxicity, part, via systemic release...
Adriamycin (ADR) is a chemotherapeutic agent useful in treating various cancers. ADR quinone-containing anthracycline and known to produce reactive oxygen species (ROS) heart. Application of this drug can have serious side effects tissues, including brain, apart from the cardiotoxic effects, which limit successful use treatment cancer. Neurons treated with demonstrate significant protein oxidation lipid peroxidation. Patients under often complain forgetfulness, lack concentration, dizziness...