A5066901683- Neuroendocrine regulation and behavior
- Stress Responses and Cortisol
- Birth, Development, and Health
- Autism Spectrum Disorder Research
- Child and Adolescent Psychosocial and Emotional Development
- Tryptophan and brain disorders
- Genetics and Neurodevelopmental Disorders
- Maternal Mental Health During Pregnancy and Postpartum
- Attention Deficit Hyperactivity Disorder
- Neurogenesis and neuroplasticity mechanisms
- Anesthesia and Neurotoxicity Research
- Neonatal and fetal brain pathology
- Heavy Metal Exposure and Toxicity
- Congenital heart defects research
- Pesticide Exposure and Toxicity
- Toxic Organic Pollutants Impact
- Parkinson's Disease Mechanisms and Treatments
- Pregnancy and preeclampsia studies
- Pluripotent Stem Cells Research
- Telomeres, Telomerase, and Senescence
- Family and Disability Support Research
- Reproductive System and Pregnancy
- Neurotransmitter Receptor Influence on Behavior
- Hearing Loss and Rehabilitation
- Adolescent and Pediatric Healthcare
University of Iowa
2016-2025
Intel (United States)
2024
Yale University
2008-2023
Carilion Clinic
2023
University at Buffalo, State University of New York
2023
University College London
2023
Virginia Tech
2023
Jacobs (United Kingdom)
2023
Carver Bible College
2020
Universidade Estadual Paulista (Unesp)
2018
Cerebellar ataxia, neuropathy and vestibular areflexia syndrome (CANVAS) is an autosomal recessive neurodegenerative disease, usually caused by biallelic AAGGG repeat expansions in RFC1. In this study, we leveraged whole genome sequencing data from nearly 10 000 individuals recruited within the Genomics England project to investigate normal pathogenic variation of RFC1 repeat. We identified three novel motifs, AGGGC (n = 6 five families), AAGGC 2 one family) AGAGG 1), associated with CANVAS...
There is increasing appreciation for the neurodevelopmental underpinnings of many psychiatric disorders. Disorders that begin in childhood such as autism, language disorders or mental retardation well adult-onset may have origins early neurodevelopment. Neural stem cells (NSCs) can be defined self-renewing, multipotent are present both embryonic and adult brain. Several recent research findings demonstrate illness with abnormal specification, growth, expansion differentiation NSCs. For...
ABSTRACT Prenatal stress is associated with altered behavioral, cognitive, and psychiatric outcomes in offspring. Due to the importance of GABAergic systems normal development disorders, prenatal effects on these neurons have been investigated animal models. delays progenitor migration, but significance early developmental disruptions for continued cells juvenile brain unclear. Here, we examined populations adult medial frontal cortex (mFC) hippocampus through stereological counting, gene...
Highlights•Postpartum liver circulates NAD metabolites to increase mammary NAD+ and NADP+ >20-fold•NR supplementation superinduces prolactin, biosynthetic programs, lactation•Weanlings of NR-fed mothers are hypoglycemia resistant advanced in motor learning•Adult offspring retain striking physical behavioral advantagesSummaryConditions metabolic stress dysregulate the metabolome. By restoring NAD, nicotinamide riboside (NR) provides resistance such conditions. We tested hypotheses that...
To understand the role of specific fibroblast growth factor receptors (FGFRs) in cortical development, we conditionally inactivated Fgfr2 or both Fgfr1 and [ conditional knock-out (cKO) double mice, respectively] radial glial cells dorsal telencephalon. are necessary for attainment a normal number excitatory neurons cerebral cortex. The action FGF appears to be through increasing self-renewal neuronal precursors within ventricular zone. Volume measurements, assessments neuron number, areal...
Prenatal stress, a risk factor for neurodevelopmental disorders (NDDs), leads to immune alterations, including offspring neuroimmune cells. Differences in outcomes may arise from whether the extent of prenatal stress crosses "thresholds" effects on specific outcomes. Therefore, we sought determine using models with different extents stress. We focused striatal outcomes, because their relevance NDDs. Pregnant CD1 mice were assigned four groups (each: N=6): no (NoS) or one following stressors...
Pyrethroid insecticides represent a broad class of chemicals used widely in agriculture and household applications. Human studies show mixed effects maternal pyrethroid exposure on fetal growth neurodevelopment. Assessment shared metabolites as biomarker for obscures specific within this broader class. To better characterize development, we investigated to permethrin, type I pyrethroid, α-cypermethrin, II development mice. Pregnant CD1 mice were exposed permethrin (1.5, 15, or 50 mg/kg),...
Insulin-like growth factor 1 (IGF1) is produced primarily in the placenta utero and an essential hormone for neurodevelopment. Specifically, how placental IGF1 production persistently influences brain unclear. This study evaluated effects of Igf1 overexpression on embryonic postnatal development, particularly striatum, a region highly linked to neurodevelopmental disorders. Placental was overexpressed via placental-targeted CRISPR manipulation. altered structure function distinctly females...
Maternal stress during pregnancy is associated with an increased risk of psychopathology in offspring. Resident immune cells the brain, microglia, may be mediators prenatal and altered neurodevelopment. Here, we demonstrate that neither exogenous pro-inflammatory cytokine, interleukin-1β (IL-1β), nor glucocorticoid hormone, corticosterone, recapitulated full effects on morphology microglial cortical plate embryonic mice; IL-1β showed greater similarity to microglia. Unexpectedly, oil vehicle...