A5035572491- Pesticide Exposure and Toxicity
- Heavy Metal Exposure and Toxicity
- Toxic Organic Pollutants Impact
- Psychosocial Factors Impacting Youth
- Stress Responses and Cortisol
- Anesthesia and Neurotoxicity Research
- Telomeres, Telomerase, and Senescence
- Air Quality and Health Impacts
- Birth, Development, and Health
- Pregnancy and Medication Impact
- Adipose Tissue and Metabolism
- Liver Disease Diagnosis and Treatment
- Metabolism, Diabetes, and Cancer
- Pesticide Residue Analysis and Safety
- Mitochondrial Function and Pathology
- Menstrual Health and Disorders
University of Iowa
2018-2025
Carver Bible College
2020
Pyrethroid insecticides represent a broad class of chemicals used widely in agriculture and household applications. Human studies show mixed effects maternal pyrethroid exposure on fetal growth neurodevelopment. Assessment shared metabolites as biomarker for obscures specific within this broader class. To better characterize development, we investigated to permethrin, type I pyrethroid, α-cypermethrin, II development mice. Pregnant CD1 mice were exposed permethrin (1.5, 15, or 50 mg/kg),...
Prenatal exposure to cypermethrin is a risk factor for adverse neurodevelopmental outcomes in children. In addition, maternal psychological stress during pregnancy has significant effects on fetal neurodevelopment and may influence end-stage toxicity offspring by altering xenobiotic metabolism. As such, this study examined of alpha-cypermethrin stress, alone combination, development, with focus neurotoxicity. CD1 mouse dams were administered 10 mg/kg or corn oil vehicle via oral gavage from...
3,3′,4,4′,5-pentachlorobiphenyl (PCB126), a dioxin-like PCB, elicits toxicity through wide array of noncarcinogenic effects, including metabolic syndrome, wasting, and nonalcoholic fatty-liver disease. Previously, we reported decreases in the transcription several enzymes involved gluconeogenesis, before early onset lipid accumulation. Hence, this study was aimed at understanding impact resultant gluconeogenic on growth, weight, metabolism liver, upon extended exposure. Male Sprague Dawley...
Telomeres are important to chromosomal stability, and changes in their length correlate with disease, potentially relevant brain disorders. Assessing telomere human is invasive, but whether peripheral tissue correlates that not known. Saliva, buccal, blood, samples were collected at time points before, during, after subjects undergoing neurosurgery ( n = 35) for intractable epilepsy. DNA was isolated from average assessed by qPCR. Correlations of between calculated across subjects. When data...
Pyrethroid insecticides are widely used throughout agriculture and household products. Recent studies suggest that prenatal exposure to these may adversely affect fetal development; however, little is known about the distribution of chemicals in pregnant animals. The present study aimed address this gap knowledge by investigating two commonly pyrethroid insecticides, permethrin α-cypermethrin, maternal tissues CD-1 mice. Dams were dosed from gestational days 6 16 via oral gavage with (1.5,...
This standard operating procedure uses the QuEChERS extraction method for determination of α-cypermethrin levels in serum and other samples from animal studies using gas chromatography with electron capture detection.
Pyrethroid insecticides are widely used throughout agriculture and household products. Recent studies suggest that prenatal exposure to these may adversely affect fetal development; however, little is known about the distribution of chemicals in pregnant animals. The present study aimed address this gap knowledge by investigating two commonly pyrethroid insecticides, permethrin a-cypermethrin, maternal tissues CD-1 mice. Dams were dosed from gestational days 6 16 via oral gavage with (1.5,...