Jessica Lynch
A5023676631- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Animal Virus Infections Studies
- SARS-CoV-2 detection and testing
- CRISPR and Genetic Engineering
- COVID-19 epidemiological studies
- Drug Transport and Resistance Mechanisms
- Sepsis Diagnosis and Treatment
- Regulation of Appetite and Obesity
- vaccines and immunoinformatics approaches
- Neuroinflammation and Neurodegeneration Mechanisms
- Alzheimer's disease research and treatments
- Gene expression and cancer classification
- Barrier Structure and Function Studies
- Antibiotic Use and Resistance
- Virus-based gene therapy research
- Neuropeptides and Animal Physiology
- COVID-19 and Mental Health
- Intensive Care Unit Cognitive Disorders
- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- Viral gastroenteritis research and epidemiology
- CAR-T cell therapy research
- Adipokines, Inflammation, and Metabolic Diseases
- Pain Mechanisms and Treatments
University College London
2019-2025
Hampshire Hospitals NHS Foundation Trust
2020-2022
Basingstoke and North Hampshire Hospital
2020-2022
University of Strathclyde
2022
Janssen (United States)
2018-2022
National Institute for Health Research
2021
MRC Biostatistics Unit
2021
Public Health England
2021
University of Cambridge
2021
UK Research and Innovation
2021
Global dispersal and increasing frequency of the SARS-CoV-2 spike protein variant D614G are suggestive a selective advantage but may also be due to random founder effect. We investigate hypothesis for positive selection in United Kingdom using more than 25,000 whole genome sequences. Despite availability large dataset, well represented by both 614 variants, not all approaches showed conclusive signal selection. Population genetic analysis indicates that 614G increases relative 614D manner...
The SARS-CoV-2 delta (B.1.617.2) variant was first detected in England March, 2021. It has since rapidly become the predominant lineage, owing to high transmissibility. is suspected that associated with more severe disease than previously dominant alpha (B.1.1.7) variant. We aimed characterise severity of compared by determining relative risk hospital attendance outcomes.
Patterns and bottlenecks A year into the severe acute respiratory syndrome coronavirus 2 pandemic, we are experiencing waves of new variants emerging. Some these have worrying functional implications, such as increased transmissibility or antibody treatment escape. Lythgoe et al. undertaken in-depth sequencing more than 1000 hospital patients' isolates to find out how virus is mutating within individuals. Overall, there seem be consistent reproducible patterns within-host diversity. The...
Decreased clearance is the main reason amyloid-β protein (Aβ) increased in brains of patients with Alzheimer's disease (AD). The neurovascular hypothesis states that this decreased caused by impairment low density lipoprotein r
Leptin, a pleiotropic adipokine, is central regulator of appetite and weight key immunomodulatory protein. Although inborn leptin deficiency causes gain, it unclear whether induced in adult wild-type animals would be orexigenic. Previous work with potent competitive antagonist did not induce true metabolic state mice because short circulating half-life. In this study, we increased the half-life by pegylation, which resulted significantly bioavailability retaining antagonistic activity. Mice...
Abstract Background and Hypothesis Delusions are classified into themes but the range of reported in literature has never been examined extent to which they differ prevalence, or relate clinical characteristics cultural variation, remains poorly understood. Study Design We identified studies reporting delusional theme prevalence adults with psychosis completed two multivariate, multilevel, random-effects meta-analyses: one including data from structured assessment scales only another also ad...
Abstract Extensive global sampling and whole genome sequencing of the pandemic virus SARS-CoV-2 have enabled researchers to characterise its spread, identify mutations that may increase transmission or enable escape therapies vaccines. Two important components viral spread are how frequently variants arise within individuals, likely they be transmitted. Here, we within-host diversity SARS-CoV-2, extent which genetic is transmitted, by quantifying variant frequencies in 1390 clinical samples...
Insulin transported across the blood-brain barrier (BBB) has many effects within central nervous system. transport is not static but altered by obesity and inflammation. Lipopolysaccharide (LPS), derived from cell walls of Gram-negative bacteria, enhances insulin BBB also releases nitric oxide (NO), which opposes LPS-enhanced transport. Here we determined role NO synthase (NOS) in mediating LPS on The activity all three NOS isoenzymes was stimulated vivo LPS. Endothelial inducible together...
<i>Objectives:</i> The cytokines interleukin (IL)-1β and IL-6 are modulators of the neuroimmune axis have been implicated in neuronal cell death cascades after ischemia or infection. Previous work has shown that some cross-species conservation exists between human rodent blood-brain barrier (BBB) transport systems. To further assess cytokine across BBB, current studies investigated permeability inhibition ovine IL-1β mouse. <i>Methods:</i> was radioactively labeled...
There is a lack of biomarkers validated for assessing clinical deterioration in patients with COVID-19 on presentation to secondary or tertiary care. This evaluation looked at the potential application C reactive protein (CRP), procalcitonin, mid-regional proadrenomedullin (MR-proADM) and white cell count support prediction outcomes.135 presenting Hampshire Hospitals NHS Foundation Trust between April June 2020 confirmed have via reverse-transcription-qPCR were included. Biomarkers from...
Although pain was previously not considered an important element of multiple sclerosis (MS), recent evidence indicates that over 50% MS patients suffer from chronic pain. In the present study, we utilized Theiler's murine encephalomyelitis virus (TMEV) model to examine whether changes in nociception occur during disease progression and investigate sex influences development or disease-associated neurological symptoms. Using rotarod assay, TMEV infected male mice displayed increased deficits...
Background: There is a lack of knowledge about what factors may impede or facilitate engagement in psychological interventions people with motor neuron disease (pwMND) and how such can be adapted to best meet the needs this population. Objectives: To explore preferences pwMND respect interventions, adapt for pwMND. Methods: A series semi-structured interviews (n = 22) workshops 3) were conducted 15), informal caregivers 10), MND healthcare professionals 12). These explored concerns that...
Abstract Mitigation of SARS-CoV-2 transmission from international travel is a priority. We evaluated the effectiveness travellers being required to quarantine for 14-days on return England in Summer 2020. identified 4,207 travel-related cases and their contacts, 827 associated genomes. Overall, was with lower rate impact greatest 16–20 age-group. 186 genomes were sufficiently unique identify clusters. Fewer genomically-linked observed index who returned countries requirement compared no...
Purpose: This study evaluated a new subretinal method for delivery of human or pig umbilical tissue–derived cells (hUTC pUTC, respectively) using novel injection cannula and suprachoroidal approach in Göttingen minipig eyes. hUTC (palucorcel) are currently under development treating geographic atrophy humans. Methods: Twenty-four minipigs (divided into eight groups) were subretinally administered palucorcel, vehicle. In some cases, fluorescently labeled vehicle administered. Conjunctival...
Nonclinical development strategies for gene therapies are unique from other modalities. The European Federation of Pharmaceutical Industries and Associates (EFPIA) Gene Therapy Working Group surveyed EFPIA member nonmember pharmaceutical biotechnology companies about their current practices designing implementing nonclinical toxicology studies to support the viral vector-delivered in vivo therapies. Compiled responses 17 indicated that these had some variability species selection,...
A low procalcitonin (PCT) concentration facilitates exclusion of bacterial co-infections in COVID-19, but high costs associated with PCT measurements preclude universal adoption. Changes inflammatory markers, including C-reactive protein (CRP), can be concordant, and predicting concentrations may avoid redundant tests support more cost-effective deployment this diagnostic biomarker.To explore whether, values could predicted by the presence CRP concentrations.Unselected cohort 224 COVID-19...