A5065664661- Neonatal and fetal brain pathology
- Neuroscience of respiration and sleep
- Neonatal Respiratory Health Research
- Reading and Literacy Development
- Neural dynamics and brain function
- Anesthesia and Neurotoxicity Research
- Neuroscience and Neuropharmacology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Barrier Structure and Function Studies
- EEG and Brain-Computer Interfaces
- Language Development and Disorders
- Neurogenesis and neuroplasticity mechanisms
- Genetics and Neurodevelopmental Disorders
- Immune Response and Inflammation
- Cardiac Arrest and Resuscitation
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Traumatic Brain Injury and Neurovascular Disturbances
- Drug Transport and Resistance Mechanisms
- S100 Proteins and Annexins
- Infant Development and Preterm Care
- Reproductive Physiology in Livestock
- Traumatic Brain Injury Research
- Cognitive Abilities and Testing
- Sleep and Wakefulness Research
Regis College
2017-2022
Providence College
2010-2016
Rhode Island College
2010-2016
Women & Infants Hospital of Rhode Island
2010-2014
Brown University
2009-2014
University of Connecticut
2004-2009
Harvard University
2004
Beth Israel Deaconess Medical Center
2004
The brains of individuals with developmental dyslexia have neocortical neuronal migration abnormalities including molecular layer heterotopias, laminar dysplasias, and periventricular nodular heterotopias (PNH). RNA interference (RNAi) Dyx1c1, a candidate susceptibility gene, disrupts in developing embryonic neocortex. Using utero electroporation, we cotransfected cells the rat ventricular zone (VZ) at E14/15 short hairpin vectors targeting Dyx1c1 along either plasmids encoding enhanced...
Abstract Hypoxia ischemia (HI; reduced blood oxygenation and/or flow to the brain) represents one of most common injuries for both term and preterm/very low birth weight (VLBW) infants. These children experience elevated incidence cognitive sensory processing disabilities, including language based learning disabilities. Clinical data also indicate more substantial long‐term deficits HI injured male babies as compared females. Previously, we reported significant in rapid auditory spatial rats...
Abstract Hypoxia ischemia (HI; reduced blood oxygenation and/or flow to the brain) represents one of most common injuries for both term and preterm/very low birth weight (VLBW) infants. These children experience elevated incidence cognitive sensory processing disabilities, including language based learning disabilities. Clinical data also indicate more substantial long‐term deficits HI injured male babies as compared females. Previously, we reported significant in rapid auditory spatial rats...
Working and reference memory are commonly assessed using the land based radial arm maze. However, this paradigm requires pretraining, food deprivation, may introduce scent cue confounds. The eight-arm water maze is designed to evaluate working performance simultaneously by requiring subjects use extra-maze cues locate escape platforms remedies limitations observed in designs. Specifically, required avoid arms previously used for during each testing day (working memory) as well fixed arms,...
<i>Objectives:</i> The cytokines interleukin (IL)-1β and IL-6 are modulators of the neuroimmune axis have been implicated in neuronal cell death cascades after ischemia or infection. Previous work has shown that some cross-species conservation exists between human rodent blood-brain barrier (BBB) transport systems. To further assess cytokine across BBB, current studies investigated permeability inhibition ovine IL-1β mouse. <i>Methods:</i> was radioactively labeled...
Rodent studies using cortical removal techniques, ranging from transient deactivation to surgical ablation of cortex, reveal the importance auditory integrity in detecting short silent gaps white noise (2-15 ms). Processing limits for longer under decorticate conditions rats remain unknown. Determining temporal threshold subcortical resolution could, however, shed light on both normal hierarchical processing acoustic stimuli, as well etiology anomalies following developmental disruption. To...
Disruptions in the development of neocortex are associated with cognitive deficits humans and other mammals. Several genes contribute to neocortical development, research into behavioral phenotype specific gene manipulations is advancing rapidly. Findings include evidence that variants human DYX1C1 may be an increased risk developmental dyslexia. Concurrent has shown rat homolog for this modulates critical parameters early cortical including neuronal migration. Moreover, recent studies have...
The current study investigated the behavioral and neuroanatomical effects of embryonic knockdown candidate dyslexia susceptibility gene (CDSG) homolog Dyx1c1 through RNA interference (RNAi) in rats. Specifically, we examined long-term on visual attention abilities male rats, addition to assessing rapid complex auditory processing and, for first time, female Our results replicated prior evidence acoustic deficits rats revealed new comparable Moreover, found that knocking down produced...
Brain-derived neurotrophic factor (BDNF), a key player in regulating synaptic strength and learning, is dysregulated following traumatic brain injury (TBI), suggesting that stimulation of BDNF signaling pathways may facilitate functional recovery. This study investigates whether CN2097, peptidomimetic ligand which targets the scaffold protein, postsynaptic density protein 95, to enhance downstream tropomyosin-related kinase B, receptor for BDNF, can improve neurological function after TBI....
Abstract Auditory temporal processing deficits have been suggested to play a causal role in language learning impairments, and evidence of cortical developmental anomalies (microgyria (MG), ectopia) has reported for language‐impaired populations. Rodent models linked these features, by showing auditory discrimination rats with neuronal migration (MG, ectopia). Since from human studies suggests that training both speech non‐speech acoustic stimuli may improve performance developmentally...
Interleukin (IL)-1β and IL-6 have been implicated in brain development, injury progression, fetal/maternal immune interactions. We examined IL-1β protein expression cerebral cortex (CC) white matter (WM) from non-ischemic ovine fetuses at 87-90, 122-127, 135-137 days of gestation, pregnant ewes 87-90 exposed to 48 or 72h reperfusion after ischemia. Protein was determined by Western immunoblot. In CC, higher (P<0.05) adult sheep than 122-127 days, adults gestation. fetal WM, but did not...
Inter-alpha inhibitor proteins (IAIPs) found in relatively high concentrations human plasma are important inflammation. IAIPs attenuate brain damage young and adult subjects, decrease during sepsis necrotizing enterocolitis premature infants, sepsis-related inflammation newborn rats. Although a few studies have reported organ-specific IAIP expression, information is not available on age-dependent expression. Given evidence suggesting newborns, we examined expression plasma, cerebral cortex...
Neuroinflammation and dysfunction of the blood-brain barrier (BBB) are two prominent mechanisms secondary injury in neurotrauma. It has been suggested that Toll-like receptors (TLRs) play important roles initiating propagating neuroinflammation resulting from traumatic brain (TBI), but potential beneficial effects targeting these TBI have not broadly studied. Here, we investigated effect TLRs with proteoglycan 4 (PRG4) on post-traumatic BBB function. PRG4 is a mucinous glycoprotein strong...