A5102988797- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Genetic Neurodegenerative Diseases
- Long-Term Effects of COVID-19
- Transcranial Magnetic Stimulation Studies
- Glycogen Storage Diseases and Myoclonus
- Autism Spectrum Disorder Research
- Autoimmune Neurological Disorders and Treatments
- Intensive Care Unit Cognitive Disorders
- Muscle activation and electromyography studies
- Facial Nerve Paralysis Treatment and Research
- Obsessive-Compulsive Spectrum Disorders
- Neural and Behavioral Psychology Studies
- Nerve Injury and Rehabilitation
- Vestibular and auditory disorders
- COVID-19 and Mental Health
- Cerebrovascular and Carotid Artery Diseases
- Psychosomatic Disorders and Their Treatments
- Conducting polymers and applications
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Peripheral Neuropathies and Disorders
- Neuroscience and Neuropharmacology Research
- Motor Control and Adaptation
- Botulinum Toxin and Related Neurological Disorders
- Cardiovascular Disease and Adiposity
Istituto Neurologico Mediterraneo
2024-2025
Sapienza University of Rome
2023-2024
Magna Graecia University
2024
Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda
2013-2021
University of Milan
2020
To evaluate the effects of cerebellar transcranial alternating current stimulation (tACS) delivered at cerebellar-resonant frequencies, i.e., theta (θ) and gamma (γ), on upper limb motor performance cerebellum-primary cortex (M1) connectivity, as assessed by cerebellar-brain inhibition (CBI), in healthy subjects. Participants underwent cerebellar-tACS while performing three cerebellar-dependent tasks: (i) rhythmic finger-tapping, (ii) arm reaching-to-grasp ('grasping') (iii)...
Abstract Essential tremor (ET) is a heterogeneous disorder characterized by bilateral upper limbs action and, possibly, neurological signs of uncertain significance, including voluntary movement abnormalities and cognitive disturbances, i.e., the so-called ‘soft’ configuring ET-plus definition. While motor disturbances often coexist in ET, their interrelationship remains largely unexplored. Here we aim to further investigate relationship between symptoms, objectively assessed through...
Bradykinesia is the hallmark feature of Parkinson's disease (PD); however, it can manifest in other conditions, including essential tremor (ET), and healthy elderly individuals.Here we assessed whether bradykinesia features aid distinguishing PD, ET, individuals.We conducted simultaneous video kinematic recordings finger tapping 44 PD patients, 69 ET 77 individuals. Videos were evaluated blindly by expert neurologists. Kinematic analyzed. We calculated inter-raters agreement compared data...
Abstract Introduction Aging is commonly linked to motor impairment. However, the relationship between performance across age groups and frailty remains unexplored through objective analysis. Objective To kinematically evaluate in older younger adults investigate its potential connection frailty. Methods We included 65 healthy subjects (40 females, range 46–83 years). used kinematic techniques study finger-tapping measure several movement parameters, i.e., number of movements, rhythm,...
In this research, our primary objective was to explore the correlation between basal ganglia dopaminergic neurotransmission, assessed using 123I-FP-CIT (DAT-SPECT), and finger movements abnormalities in patients with Essential Tremor (ET) Parkinson's Disease (PD). We enrolled 16 ET, 17 PD, 18 healthy controls (HC). Each participant underwent comprehensive clinical evaluations, kinematic assessments of tapping, DAT-SPECT imaging. The scans were subjected both visual semi-quantitative analysis...
Abstract Background Subtle parkinsonian signs, i.e., rest tremor and bradykinesia, are considered soft signs for defining essential (ET) plus. Objectives Our study aimed to further characterize subtle in a relatively large sample of ET patients from clinical neurophysiological perspective. Methods We employed scales kinematic techniques assess 82 patients. Eighty healthy controls matched gender age were also included. The primary focus our was conduct comparative analysis (without any signs)...
Abstract The “interlimb transfer” phenomenon consists of improved performance the trained and untrained contralateral limbs after unilateral motor practice. We here assessed whether a visuomotor learning task can be transferred from one hemisphere to other, this occurs symmetrically, cortical neurophysiological correlates phenomenon, focusing on interhemispheric connectivity measures. enrolled 33 healthy subjects (age range: 24–73 years). Participants underwent two randomized sessions, which...
Disruption of motor control in the alien hand syndrome might result from a dissociation between intentions and sensory information. We hypothesized that voluntary this condition could improve by restoring congruency visual feedback. The present study shows that, one patient with right syndrome, use mirror box paradigm improved speed. speculate feedback provided increases sense congruence intention feedback, leading to improvement.
Introduction: The main clinical manifestation of the novel Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is respiratory issues. Neurological manifestations are being increasingly recognized, including febrile seizures, headache, dizziness, and myalgia, as well encephalopathy, encephalitis, stroke, acute peripheral nerve diseases. Cerebral vasculitis rarely reported. We describe a case SARS-CoV-2 interstitial pneumonia complicated by flaccid tetraplegia due to Guillain-Barré...
Abstract Background Opicapone (OPC) is a third-generation, selective peripheral COMT inhibitor that improves L-DOPA bioavailability and reduces OFF time end-of-dose motor fluctuations in Parkinson’s disease (PD) patients. Objectives In this study, we objectively assessed the effects of adding OPC to on bradykinesia PD through kinematic analysis finger movements. Methods We enrolled 20 treated patients with fluctuations. Patients underwent two experimental sessions (L-DOPA, + OPC), separated...
In patients with Parkinson's disease, the connectivity between two primary motor cortices may be altered. However, correlation asymmetries of abnormal interhemispheric connections and bradykinesia features has not been investigated. Furthermore, potential effects dopaminergic medications on this issue remain largely unclear. The aim present study is to investigate in disease by transcranial magnetic stimulation explore relationship inhibition feature asymmetry patients. Additionally, we...
People with tetraplegia are often lacking grip strength, causing impairment in activities of daily living. For them, improving hand function is a priority because it important for autonomy and participation life. A tendon transfer surgery may be an option to improve the tenodesis grip, but invasive procedure. Alternatively similar effect can produced, using non-invasive method. We have previously described how myoelectrically controlled functional electrical stimulation (MeCFES) efficient...
<title>Abstract</title> <bold>Introduction:</bold>Essential tremor (ET) is a heterogeneous disorder characterized by bilateral upper limbs action and, possibly, neurological signs of uncertain significance, including voluntary movement abnormalities and cognitive disturbances, i.e., the so-called ‘soft’ configuring ET-plus definition. While motor disturbances often coexist in ET, their interrelationship remains largely unexplored. Here we aim to further investigate relationship between...
Tremor disorders have various genetic causes.
Abstract Spinocerebellar ataxias (SCAs) are characterized by substantial phenotypic variability. Among them, SCA42 is a rare non-expansion entity presenting with slowly progressive cerebellar syndrome but whose clinical spectrum may be also wider. A 53-year-old male presented myoclonus-ataxia and intellectual disability. Genetic screening revealed novel c.3835G > (p. Asp1279Asn) variant in the CACNA1G gene. SCA caused mutations on chromosome 17q21, encoding Ca(V)3.1, low-threshold...
In the past few years, SARS-CoV-2 infection has substantially impacted public health. Alongside respiratory symptoms, some individuals have reported new neurological manifestations or a worsening of pre-existing conditions. We previously documented two cases essential tremor (ET) who experienced deterioration in following infection. However, effects on ET remain largely unexplored. This study aims to evaluate impact relatively broad sample patients by retrospectively comparing their clinical...
article: The management of a COVID-free inpatient rehabilitation in large COVID-19 hospital Milan during the outbreak - European Journal Physical and Rehabilitation Medicine 2020 October;56(5):690-2 Minerva Medica Journals