A5007380900- Cholangiocarcinoma and Gallbladder Cancer Studies
- Berberine and alkaloids research
- Drug-Induced Hepatotoxicity and Protection
- Rabbits: Nutrition, Reproduction, Health
- Fungal Biology and Applications
- Glycosylation and Glycoproteins Research
- Liver physiology and pathology
- Phytochemistry and Bioactive Compounds
- Phytochemistry and biological activity of medicinal plants
- Botanical Research and Chemistry
- Synthesis and bioactivity of alkaloids
- Drug Transport and Resistance Mechanisms
- Influenza Virus Research Studies
- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Ginger and Zingiberaceae research
- Medicinal Plant Pharmacodynamics Research
- Pediatric Hepatobiliary Diseases and Treatments
- Biochemical Analysis and Sensing Techniques
- Caveolin-1 and cellular processes
- Genomics, phytochemicals, and oxidative stress
- Menopause: Health Impacts and Treatments
- Plant-derived Lignans Synthesis and Bioactivity
- Coronary Artery Anomalies
- Congenital Ear and Nasal Anomalies
Sapienza University of Rome
2009-2021
University of Padua
1989-2002
University of Messina
1994-1997
University of Genoa
1996
The aim of this study was to determine whether GSH-C4, a hydrophobic glutathione derivative, affects in vitro and vivo influenza virus infection by interfering with redox-sensitive intracellular pathways involved the maturation viral hemagglutinin (HA).GSH-C4 strongly inhibited A replication cultured cells lethally infected mice, where it also reduced lung damage mortality. In cell-culture studies, GSH-C4 arrested HA folding; disulfide-rich glycoprotein remained endoplasmic reticulum as...
Influenza virus replicates intracellularly exploiting several pathways involved in the regulation of host responses. The outcome and severity infection are thus strongly conditioned by multiple factors, including age, sex, metabolic, redox conditions target cells. Hormones also important determinants immune responses to influenza recently proposed prophylaxis treatment. This study shows that female mice less susceptible than males mouse-adapted (A/PR8/H1N1). Compared with males, PR8-infected...
Cholangiocarcinoma (CCA) is an aggressive group of biliary tract cancers, characterized by late diagnosis, low effective chemotherapies, multidrug resistance, and poor outcomes. In the attempt to identify new therapeutic strategies for CCA, we studied antiproliferative activity a combination between doxorubicin natural sesquiterpene β-caryophyllene in cholangiocarcinoma Mz-ChA-1 cells nonmalignant H69 cholangiocytes, under both long-term metronomic schedules. The modulation STAT3 signaling,...
<i>Background:</i><i>Cassia angustifolia </i>L. (senna) is traditionally used as a laxative. Its major components are sennosides that responsible for the laxative effect. Senna recommended short-term treatment of acute constipation. Nevertheless people use its preparations self-medication, often long periods, to treat chronic constipation thus exposing themselves adverse reactions. Most reactions were associated with hepatotoxicity. <i>Aims:</i> The...
Alpha-synuclein (α-syn) is a presynaptic neuronal protein and its structural alterations play an important role in the pathogenesis of neurodegenerative diseases, such as Parkinson's disease (PD). It has been originally described brain aggregated α-syn also found peripheral nerves including enteric nervous system (ENS) PD patients. ENS network neurons glia gut wall which controls gastrointestinal function independently from central system. Moreover, two types epithelial cells are crucial...
The structure of the photophores (luminous organs) two species deep‐sea fishes from Strait Messina, Argyropelecus hemigymnus and Maurolicus muelleri , was examined. Although significant structural differences were identified between species, especially in photophore organization distribution, ultrastructural comparisons indicated a marked similarity them. photocytes exhibited numerous secretory granules, different electron density, embedded an extremely developed rough endoplasmic reticulum....
The maternal separation protocol in rodents is a widely recognized model of early life stress allowing acute and chronic physiological consequences to be studied. An 1H NMR-based metabolomic approach was applied urines evaluate the systemic metabolic female rats after beginning weaning 4 weeks later when were reaching adulthood. Furthermore, because considered as mimicking inflammatory bowel syndrome, lactulose/mannitol test used influence postnatal on gut permeability mucosal barrier...
Angiogenesis plays a fundamental role in tumor growth and progression. It is regulated by several factors, including vascular endothelial factor protein family (VEGF) its receptors, which are probably the most important factors responsible for development of new vessels. The VEGF includes members: VEGF-A, VEGF-B, VEGF-C, VEGF-D, VEGF-E, placental (PlGF), their receptors VEGFR-1, VEGFR-2 VEGFR-3. Other relevant represented angiopoietins, thrombospondin-1, endothelins. However, since...
Cholangiocarcinoma (CCA) is an aggressive biliary tract malignancy with limited treatment options and low survival rates. The intrahepatic subtype comprises two forms: mucin-iCCA mixed-iCCA. Epidermal growth factor-like domain multiple (EGFL7) overexpressed in less differentiated liver tumors. aim of this study was to assess the presence EGFL7 due its possible role CCA. Hematoxylin Eosin periodic acid-Schiff staining were used evaluate morphological aspects glycogen deposition....
There is a general consensus that liver fibrosis in humans potentially reversible, while scepticism prevails on the concept cirrhosis can be truly reversed. The availability of suitable experimental models fundamental for disease research. murine model induced by carbon tetrachloride (CCl(4)) reproduces both histological picture postnecrotic and its biochemical clinical parameters. Normal hepatic structure modified formation regeneration nodules. Fibrosis represents morphological element an...
Conclusion: The results of the present study reject hypothesis that epithelial inclusions into ossicles could cause cholesteatoma recurrences, but strongly suggest performance a safe cleaning procedure for ossicular remnants to make them usable in ossiculoplasty patients with partially or non-encapsulated cholesteatoma. Objective: aim was define, before any sort procedure, if there is inclusion inside and findings be correlated surgical aspect Methods: specimens used this comprised 19 mallei...
The severity and site of hypertrophy is important in determining the clinical picture natural history hypertrophic cardiomyopathy (HCM). We evaluated left ventricular by means two-dimensional echocardiographic score index, correlated these findings with symptoms, electrovector-cardiographic data, arrhythmias. A total 42 patients HCM were studied examination, ECG, VCG, M-mode 2D echocardiography, 24-h Holter monitoring. extent process calculated a system. ventricle was divided into 11...
Some morphometrical parameters of the axons making up contralateral sciatic nerves, both in male and female rabbits were calculated compared by means a Zeiss Vidas image analyser (Ober Kochen, Germany). The results show that fibres constituting left nerve have greater mean diameter but lower density those constitution right nerve. This suggests myelinated unmyelinated do not vary from to female. On other hand, G ratio do, since nerves on side (in sexes) higher morphometric values, average, than ones.
Cholangiocarcinoma (CCA) represents a particular type of liver cancer originating from the epithelial cells lining intrahepatic and extrahepatic biliary tree. It is often clinically silent until it becomes an advanced disease with obstructive symptoms poor prognosis for patients [1]. In this context, searching alternative therapeutic strategies pivotal goal in battle against cancer. present research, β-caryophyllene (CRY) oxide (CRYO), two natural sesquiterpenes protective properties [2],...