A5055066498- Drug Transport and Resistance Mechanisms
- Essential Oils and Antimicrobial Activity
- Phytochemicals and Antioxidant Activities
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Shoulder Injury and Treatment
- Orthopedic Surgery and Rehabilitation
- Biological Activity of Diterpenoids and Biflavonoids
- Genomics, phytochemicals, and oxidative stress
- Natural product bioactivities and synthesis
- Elbow and Forearm Trauma Treatment
- Phytochemistry and Biological Activities
- Cannabis and Cannabinoid Research
- Hops Chemistry and Applications
- Natural Compound Pharmacology Studies
- Medicinal plant effects and applications
- Pharmacology and Obesity Treatment
- GABA and Rice Research
- Plant biochemistry and biosynthesis
- Pomegranate: compositions and health benefits
- Natural Antidiabetic Agents Studies
- Drug-Induced Hepatotoxicity and Protection
- Computational Drug Discovery Methods
- Lipoproteins and Cardiovascular Health
- Natural Compounds in Disease Treatment
- Carcinogens and Genotoxicity Assessment
Sidac (Italy)
2025
Sapienza University of Rome
2015-2024
Istituto Superiore di Sanità
2023-2024
University of Padua
2023
National Institute of Health
2023
Ministero della Salute
2023
Institute for the Chemistry of OrganoMetallic Compounds
2019
Multidisciplinary Digital Publishing Institute (Switzerland)
2019
Accademia Italiana Medicina Osteopatica
2017
Alzheimer's disease (AD) has a complex and not-fully-understood etiology. Recently, the serotonin receptor 5-HT6 emerged as promising target for AD treatment; thus, here new series of 5-HT6R ligands with 1,3,5-triazine core selenoether linkers was explored. Among them, 2-naphthyl derivatives exhibited strong affinity selectivity over 5-HT1AR (13–15), 5-HT7R (14 15), 5-HT2AR (13). Compound 15 displayed high other central nervous system receptors low risk cardio-, hepato-, nephrotoxicity no...
Abstract Background Quadrilateral space syndrome is a painful disorder of the shoulder caused by static or dynamic entrapment axillary nerve and posterior humeral circumflex artery. It was first described in 1983; however, it an uncommon that initially presents with nonspecific pain selective deltoid atrophy, diagnosis often delayed owing to its rarity. Young athletes overhead sports are more commonly affected this syndrome. Symptoms quadrilateral include silent persistent pain,...
The chemical composition of the inflorescences from four Cannabis sativa L. monoecious cultivars (Ferimon, Uso-31, Felina 32 and Fedora 17), recently introduced in Lazio Region, was monitored over season June to September giving indications on their sensorial, pharmaceutical/nutraceutical proprieties. Both untargeted (NMR) targeted (GC/MS, UHPLC, HPLC-PDA/FD spectrophotometry) analyses were carried out identify quantify compounds different classes (sugars, organic acids, amino cannabinoids,...
A hydroalcoholic extract from female inflorescences of Humulus lupulus L. (HOP extract) was evaluated for its anti-influenza activity. The ability the to interfere with different phases viral replication assessed, as well effect on intracellular redox state, being unbalanced versus oxidative state in infected cells. radical scavenging power, inhibition lipoperoxidation, and ferric reducing activity were assayed antioxidant mechanisms. phytochemical characterization also performed. We found...
DR2B and DR2C extracts, obtained by ethanolic maceration of peel from commercially physiologically ripe aubergine berries, were studied for the antioxidative cytoprotective properties anti-HSV-1 activity, in line with evidence that several antioxidants can impair viral replication maintaining reducing conditions host cells. The effects against tBOOH-induced damage assessed Caco2 cells, while antiviral activity was Vero cells; polyphenolic fingerprints characterized integrated phytochemical...
Background/Aim: The natural sesquiterpenes β-caryophyllene (CRY) and oxide (CRYO) were evaluated for their potential chemosensitizing properties. Materials Methods: CRY CRYO cytotoxicity was tested against the Caco-2, CCRF/CEM CEM/ADR5000 human cancer cell lines. Furthermore, combination experiments carried out in order to study ability of increase doxorubicin cytotoxicity. possible interference with functionality ATP-binding cassette (ABC)-transporters also investigated by Rhodamine123...
Pomegranate peel is a natural source of phenolics, claimed to possess healing properties, among which are antioxidant and antidiabetic. In the present study, an ethyl acetate extract, obtained by Soxhlet from Dente di Cavallo DC2 pomegranate (PGE) characterized contain 4% w/w ellagic acid, has been evaluated for its hypoglycemic, antiglycation, antioxidative cytoprotective in order provide possible evidence future nutraceutical applications. The α-amylase α-glucosidase enzyme inhibition,...
Doxorubicin represents a valuable choice for different cancers, although the severe side effects occurring at high effective dose limits its clinical use. In present study, potential strategies to potentiate low-dose doxorubicin efficacy, including metronomic schedule, characterized by short and repeated exposure anticancer drug, combination with natural chemosensitizing sesquiterpenes β-caryophyllene oxide, were assessed in human hepatoma HepG2 cells. The involvement of P-glycoprotein...
The natural sesquiterpene β-caryophyllene (CRY) has been highlighted to possess interesting pharmacological potentials, particularly due its chemopreventive and analgesic properties. However, the poor solubility of this in aqueous fluids can hinder uptake into cells, resulting inconstant responses biological systems, thus limiting application. Therefore, identifying a suitable pharmaceutical form for increasing CRY bioavailability represents an important requirement exploiting potential. In...
SPME-GC-MS and PTR-ToF-MS techniques were applied to describe the content of volatile flavor compounds in a craft beer before after adding spirulina. The obtained results showed that profile two samples differed. Furthermore, chemically characterize biomass spirulina, derivatization reaction followed by GC-MS analysis was performed, highlighting high molecules belonging different chemical classes, such as sugars, fatty acids carboxylic acids. A spectrophotometric total polyphenols tannins,...