A5067246792- Nanoparticle-Based Drug Delivery
- Advanced Drug Delivery Systems
- Hydrogels: synthesis, properties, applications
- Lipid Membrane Structure and Behavior
- Characterization and Applications of Magnetic Nanoparticles
- Polysaccharides Composition and Applications
- Drug Solubulity and Delivery Systems
- 3D Printing in Biomedical Research
- Microfluidic and Bio-sensing Technologies
- Polysaccharides and Plant Cell Walls
- Advancements in Transdermal Drug Delivery
- Electrospun Nanofibers in Biomedical Applications
- Essential Oils and Antimicrobial Activity
- Microbial Inactivation Methods
- biodegradable polymer synthesis and properties
- Bone Tissue Engineering Materials
- Wound Healing and Treatments
- Natural product bioactivities and synthesis
- Microencapsulation and Drying Processes
- Phytochemistry and Biological Activities
- Molecular Communication and Nanonetworks
- Proteoglycans and glycosaminoglycans research
- Silk-based biomaterials and applications
- Bee Products Chemical Analysis
- Spectroscopy Techniques in Biomedical and Chemical Research
Sapienza University of Rome
2016-2025
Pharmac
2016
In this study, gellan gum (GG), a natural polysaccharide, was used to fabricate spherical porous beads suitable as sustained drug delivery systems for oral administration. GG cross-linked with calcium ions prepare polymeric beads. Rheological studies and preliminary experiments of preparation allowed identify the CaCl2 concentrations obtaining stable particles. were formed, through ionotropic gelation technique, without presence synthetic clay laponite. The resultant analyzed dimensions...
Methacryloyl gelatin (GelMA) was blended with dextran methacrylate (DexMA) to produce polymer networks interconnected macropores via cryostructuring and radical crosslinking of the polymers at subzero temperatures. The experimental set-up optimized allow formation monolithic characterized by highly uniform structure macropores. total mass, amount gel-forming reagents particularly rheological properties GelMA resulted most critical factors for fabrication homogeneous not collapsed scaffolds....
Critical-sized bone defects and articular cartilage injuries resulting from trauma, osteonecrosis, or age-related degeneration can be often non-healed by physiological repairing mechanisms, thus representing a relevant clinical issue due to high epidemiological incidence rate. Novel tissue-engineering approaches have been proposed as an alternative common practices. This cutting-edge technology is based on the combination of three fundamental components, generally referred triad: autologous...
Cutaneous hyperpigmentation is a widespread pathology affecting large slice of the world population. In this work, we propose treatment approach based on co-delivery 4-hexylresorcinol (HR) and ginger oil (GO), using lipid nanoparticles. specific, HR GO were encapsulated within nanostructured carriers (NLCs), produced with high-shear homogenization technique, Precirol ATO 5 as solid component. Different NLCs nanoparticles (SLNs) formulations prepared in order to evaluate any additive or...
The aim of this work was to develop and characterize nanocomposite thin films containing silver nanoparticles (AgNPs), as wound dressings antifungal materials, using a green process for the nanoparticles' synthesis single step procedure preparation films. To end, polyphenol-rich extracts obtained from kiwi peels, an agri-food industrial by-product, were used reducing agent nitrate salt. AgNPs let form within film-forming solution, which composed by low acyl gellan gum plasticizing (glycerol...
Diospyros kaki L. is acknowledged for its extraordinary phytotherapeutic properties due to the presence of polyphenols, carotenoids, and flavonoids such as β-cryptoxanthin rutin. These compounds are largely distributed in skin flesh fruit. In this study, different parts persimmons were analyzed (whole fruit, peels, flesh), aiming at determining total carotenoid flavonoid content through selective extraction HPLC-DAD analysis. Obtained by a one-pot double phase extraction, organic aqueous...
The natural sesquiterpene β-caryophyllene (CRY) has been highlighted to possess interesting pharmacological potentials, particularly due its chemopreventive and analgesic properties. However, the poor solubility of this in aqueous fluids can hinder uptake into cells, resulting inconstant responses biological systems, thus limiting application. Therefore, identifying a suitable pharmaceutical form for increasing CRY bioavailability represents an important requirement exploiting potential. In...
Gellan gum-based hydrogels display limited cell adhesion ability due to the absence of cell-anchorage points usually present in proteins found extracellular matrix (ECM). This issue limits their use biomedical field as scaffolds promote tissue repair. Our work addresses this challenge by investigating polydopamine (pDA) a bioactive layer improve surface and biological properties gellan cross-linked using carbodiimide chemistry. Upon treatment with pDA layer, hydrogel displayed an increase...
In this work hydroxypropyl methylcellulose (HPMC) fast-dissolving thin films for oral administration are investigated. Furosemide (Class IV of the Biopharmaceutical Classification System) has been used as a model drug in vitro release tests using three different set-ups: Franz cell, millifluidic flow-through device, and paddle type dissolution apparatus (USP II). order to enable incorporation within HPMC films, multifunctional excipient, hydroxypropyl- β -cyclodextrin (HP- -CD) included...
Recently, magnetic nanoparticles (MNPs) have been used to trigger drug release from magnetoliposomes through a magneto-nanomechanical approach, where the mechanical actuation of MNPs is enhance membrane permeability. This result can be effectively achieved with low intensity non-thermal alternating field (AMF), which, however, found rare clinic application. Therefore, different modality generating fields has now investigated. Specifically, ability intermittent signals generated by pulsed...
In this work, Lavandula x intermedia essential oil (LEO) was encapsulated in lipid-based nanoemulsions (NanoLEO) using the solvent-displacement technique. order to preserve colloidal stability of formulation, LEO appropriately doped with incorporation different levels a water-insoluble used as ripening inhibitor. All nanoemulsion samples were evaluated terms impact on formation, physical–chemical properties, and antibacterial effectiveness against E. coli (Gram-negative) B. cereus...