A5005462346- Drug Transport and Resistance Mechanisms
- Liver Disease Diagnosis and Treatment
- Pediatric Hepatobiliary Diseases and Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Neonatal Health and Biochemistry
- Liver physiology and pathology
- Pharmacological Effects and Toxicity Studies
- Liver Diseases and Immunity
- Metabolism and Genetic Disorders
- Pregnancy and preeclampsia studies
- Drug-Induced Hepatotoxicity and Protection
- Pancreatic and Hepatic Oncology Research
- Pharmacogenetics and Drug Metabolism
- Pregnancy and Medication Impact
- Hepatocellular Carcinoma Treatment and Prognosis
- Metal complexes synthesis and properties
- RNA modifications and cancer
- Cancer Mechanisms and Therapy
- Aldose Reductase and Taurine
- Nanoparticle-Based Drug Delivery
- Peptidase Inhibition and Analysis
- Organ Transplantation Techniques and Outcomes
- Heme Oxygenase-1 and Carbon Monoxide
- Hepatitis B Virus Studies
- Cancer-related gene regulation
Instituto de Investigación Biomédica de Salamanca
2016-2025
Instituto de Salud Carlos III
2016-2025
Universidad de Salamanca
2016-2025
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
2016-2025
Centro de Investigación Biomédica en Red
2007-2024
Université Libre de Bruxelles
2024
National Institutes of Health
2024
Jackson Laboratory
2024
Institut Jules Bordet
2024
Hôpital Sainte-Marguerite
2023
Cholangiocarcinoma (CCA) includes a heterogeneous group of biliary cancers with poor prognosis. Several conditions, such as primary sclerosing cholangitis (PSC), are risk factors. Noninvasive differential diagnosis between intrahepatic CCA and hepatocellular carcinoma (HCC) is sometimes difficult. Accurate noninvasive biomarkers for PSC, CCA, HCC not available. In the search novel biomarkers, serum extracellular vesicles (EV) were isolated from (n = 43), PSC 30), or 29) patients healthy...
Cholangiocarcinoma (CCA) is a rare and heterogeneous biliary cancer, whose incidence related mortality increasing. This study investigates the clinical course of CCA subtypes (intrahepatic [iCCA], perihilar [pCCA], distal [dCCA]) in pan-European cohort.The ENSCCA Registry multicenter observational study. Patients were included if they had histologically proven diagnosis between 2010-2019. Demographic, histomorphological, biochemical, studies performed.Overall, 2,234 patients enrolled...
The placenta serves, in part, as a barrier to exclude noxious substances from the fetus. In humans, single-layered syncytium of polarized trophoblast cells and fetal capillary endothelium separate maternal circulations. P-glycoprotein is present syncytiotrophoblast throughout gestation, consistent with protective role that limits exposure fetus hydrophobic cationic xenobiotics. We have examined whether members multidrug resistance protein (MRP) family are expressed term placenta. After...
Cholestasis is associated with increased liver injury and morbidity after partial hepatectomy (PH), yet bile acids (BAs) are emerging as important mediators of regeneration. Fibroblast growth factor 15 (Fgf15, human FGF19) a BA-induced ileum-derived enterokine that governs BA metabolism. We evaluated the relevance Fgf15 in preservation homeostasis PH its potential role regenerative process.Liver regeneration was studied (-/-) (+/+) mice. The effects sequestrant cholestyramine adenovirally...
Early and differential diagnosis of intrahepatic cholangiocarcinoma (iCCA) hepatocellular carcinoma (HCC) by noninvasive methods represents a current clinical challenge. The analysis low‐molecular‐weight metabolites new high‐throughput techniques is strategy for identifying biomarkers. Here, we have investigated whether serum metabolome can provide useful biomarkers in the iCCA HCC could discriminate from HCC. Because primary sclerosing cholangitis (PSC) risk factor CCA, metabolic profiles...
Reduced drug uptake is an important mechanism of chemoresistance. Down-regulation SLC22A1 encoding the organic cation transporter-1 (OCT1) may affect response hepatocellular carcinoma (HCC) and cholangiocarcinoma (CGC) to sorafenib, a cationic drug. Here we investigated whether variants contribute sorafenib Complete sequencing selective variant identification were carried out detect single nucleotide polymorphisms (SNPs) in complementary DNA (cDNA). In HCC CGC biopsies, addition previously...
Sirtuin1 (SIRT1) regulates central metabolic functions such as lipogenesis, protein synthesis, gluconeogenesis, and bile acid (BA) homeostasis through deacetylation. Here we describe that SIRT1 tightly controls the regenerative response of liver. We performed partial hepatectomy (PH) to transgenic mice overexpress (SIRT). SIRT showed increased mortality, impaired hepatocyte proliferation, BA accumulation, profuse liver injury after surgery. The damaging phenotype in correlated with farnesoid...
The intrauterine environment is a major contributor to increased rates of metabolic disease in adults. Intrahepatic cholestasis pregnancy (ICP) liver that affects 0.5%-2% pregnant women and characterized by bile acid levels the maternal serum. influence ICP on health offspring unknown. We analyzed Northern Finland birth cohort 1985-1986 database found 16-year-old children mothers with had altered lipid profiles. Males BMI, females exhibited waist hip girth compared uncomplicated pregnancies....
A challenge in obstetrics is to distinguish pathological symptoms from those associated with normal changes of pregnancy, typified by the need differentiate whether gestational pruritus skin an early symptom intrahepatic cholestasis pregnancy (ICP) or due benign gravidarum. ICP characterized raised serum bile acids and complicated spontaneous preterm labor stillbirth. biomarker for would be invaluable diagnosis treatment enable its differentiation other maternal diseases. Three progesterone...
: Cholangiocarcinoma (CCA) comprises a group of heterogeneous biliary cancers with dismal prognosis. The etiologies most CCAs are unknown, but primary sclerosing cholangitis (PSC) is risk factor. Non-invasive diagnosis CCA challenging and accurate biomarkers lacking. We aimed to characterize the transcriptomic profile serum urine extracellular vesicles (EVs) from patients CCA, PSC, ulcerative colitis (UC), healthy individuals. Serum EVs were isolated by serial ultracentrifugations...