Jan Philipp Jonas

ORCID: 0000-0002-3134-9040
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About
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Research Areas
  • Hepatocellular Carcinoma Treatment and Prognosis
  • Pancreatic and Hepatic Oncology Research
  • Liver Disease Diagnosis and Treatment
  • Liver Disease and Transplantation
  • Gallbladder and Bile Duct Disorders
  • Cholangiocarcinoma and Gallbladder Cancer Studies
  • Pancreatitis Pathology and Treatment
  • Colorectal Cancer Treatments and Studies
  • Cancer Treatment and Pharmacology
  • Cancer, Stress, Anesthesia, and Immune Response
  • Colorectal Cancer Surgical Treatments
  • Cancer, Hypoxia, and Metabolism
  • Cancer Diagnosis and Treatment
  • Abdominal vascular conditions and treatments
  • Intestinal Malrotation and Obstruction Disorders
  • Historical Art and Culture Studies
  • Organ Donation and Transplantation
  • Blood transfusion and management
  • Vascular anomalies and interventions
  • Renal cell carcinoma treatment
  • Inflammatory Biomarkers in Disease Prognosis
  • Genetic and Kidney Cyst Diseases
  • AI in cancer detection
  • Treatment of Major Depression
  • Eosinophilic Disorders and Syndromes

University Hospital of Zurich
2021-2025

Sigmund Freud University Vienna
2023-2025

University of Zurich
2021-2024

Krankenanstalt Rudolfstiftung der Stadt Wien
2018

Medical University of Vienna
2018

Rudolfinerhaus Hospital
2016-2018

Städtisches Klinikum Karlsruhe
2007

Klinik und Poliklinik für Psychosomatische Medizin und Psychotherapie
1992

Cholangiocarcinoma (CCA) is a rare and heterogeneous biliary cancer, whose incidence related mortality increasing. This study investigates the clinical course of CCA subtypes (intrahepatic [iCCA], perihilar [pCCA], distal [dCCA]) in pan-European cohort.The ENSCCA Registry multicenter observational study. Patients were included if they had histologically proven diagnosis between 2010-2019. Demographic, histomorphological, biochemical, studies performed.Overall, 2,234 patients enrolled...

10.1016/j.jhep.2021.12.010 article EN cc-by-nc-nd Journal of Hepatology 2022-02-12

Background and Objective: Robotic distal pancreatectomy (DP) is an emerging attractive approach, but its role compared with laparoscopic or open surgery remains unclear. Benchmark values are novel objective tools for such comparisons. The aim of this study was to identify benchmark cutoffs many outcome parameters DP without splenectomy beyond the learning curve. Methods: This analyzed outcomes from international expert centers patients undergoing robotic malignant benign lesions. After...

10.1097/sla.0000000000005601 article EN Annals of Surgery 2022-07-19

Metabolic regulation is critical during liver regeneration in rodents, but human data are limited. We investigated perioperative dynamics of circulating metabolites and plasma levels glucagon-like peptide-1 (GLP-1) GLP-2, patients undergoing resections, exploring their associations with the histological phenotype metabolic dysfunction-associated steatotic disease (MASLD) posthepatectomy failure (PHLF). Eighty-one 75 from two centers between 2012 2023 were studied. Targeted quantitative...

10.21037/hbsn-24-464 article EN HepatoBiliary Surgery and Nutrition 2025-01-20

: The aim of this study was to investigate the association between intraoperative blood transfusion (BT) and short-term outcomes pancreatoduodenectomy (PD) for patients with periampullary malignancies.

10.3390/cancers16203531 article EN Cancers 2024-10-18

Surgery plays a central role in the treatment of benign and malignant pancreatic diseases. Artificial intelligence (AI) is an important upcoming technology to support surgeons pre-, intra-, postoperative diagnosis, decision-making training toward optimized patient care. Current AI applications show promising evaluation preoperative images for prediction malignancy resectability, intraoperative decision support, surgical as well risk stratification personalize management complications. This...

10.1097/jp9.0000000000000129 article EN cc-by-nc-nd Journal of Pancreatology 2023-04-25

(1) Background: The pathological tumor response of the primary to induction chemotherapy in synchronously metastasized colorectal cancer (mCRC) patients has not been investigated. aim this study was compare treated with combined vascular endothelial growth factor (VEGF) or epidermal receptor (EGFR) antibodies. (2) Methods: We present a retrospective analysis, where we included 60 consecutive potentially resectable synchronous mCRC who received either VEGF EGFR endpoint regression tumor,...

10.3390/cancers15112900 article EN Cancers 2023-05-24

The costs of the operative treatment acute appendicitis have to be verified under DRG conditions. Laparoscopic and open appendectomies in a 5-year-period were evaluated retrospectively. Analyses year 2004 performed according clinical automatic settlement (SAP / R3) direct comparison data 140 participating hospitals using same software. In 775 830 (91.8 %) started laparoscopically, 68 cases method was converted surgical procedure. Postoperative complications required radiologic interventional...

10.1055/s-2007-960647 article EN Zentralblatt für Chirurgie - Zeitschrift für Allgemeine Viszeral- Thorax- und Gefäßchirurgie 2007-04-01

Abstract Background In primarily unresectable liver tumors, ALPPS (Associating Liver Partition and Portal Vein Ligation for Staged hepatectomy) may offer curative two stage hepatectomy trough a fast extensive hypertrophy. However, concerns have been raised about the invasiveness of procedure. Full robotic has potential to reduce postoperative morbidity less invasive access. Aims The aim this study was compare perioperative outcomes open full ALPPS. Methods bicentric included cases from...

10.1093/bjs/znae118.033 article EN other-oa British journal of surgery 2024-05-01

Abstract Background Perioperative morbidity and mortality remain a point of concern for the Associating Liver Partition Portal Vein Ligation Staged hepatectomy (ALPPS) procedure. Post-hepatectomy liver failure (PHLF) after second step poses most significant risk factor futile outcome. Recovery function first ALPPS is critically important to allow sufficient this surgery. The APRI+ALBI score has been proposed as an easily assessable monitor its dynamic recovery. Aims We explored if was able...

10.1093/bjs/znae118.029 article EN other-oa British journal of surgery 2024-05-01

We aimed to assess the effect of donor pancreas extraction time (ET) on postoperative complications and graft function after transplantation (PT). analyzed all consecutive procurements for simultaneous kidney (SPK) associated PT in a Swiss transplant center over 20-year period. Pancreas ET was defined as from cold flush static storage ice. The primary endpoint surgical complications. Secondary endpoints comprised (insulin-free survival) pancreatitis. Of 115 procured grafts median 65 min...

10.1111/ctr.14846 article EN Clinical Transplantation 2022-11-02

e23208 Background: The benefit of systemic chemotherapie (5-FU based) in combination with Bevacizumab (Bev) patients (pts) metastatic colorectal cancer (mCRC) is well proven. Nevertheless, an anti-VEGF therapy for intact primary still controversial. As bleeding a well-known side effect during treatment not recommended active bleeding. Bev was reported to significantly decrease tumor perfusion, vascular volume and microvascular density. aim this analysis evaluate the safety efficacy clinical...

10.1200/jco.2016.34.15_suppl.e23208 article EN Journal of Clinical Oncology 2016-05-20

The preoperative sonographic findings in 166 patients with confirmed colorectal carcinomas were analysed to determine the frequency of focal liver lesions. In 15 metastases found at first examination and a further 16 they detected subsequently. Homogeneous high-intensity echoes only one patient. Cysts occurred 13 haemangiomas 11 patients. latter showed solitary lesions which exceeded 25 mm patient otherwise measured between 6 mm. Focal abnormalities fat distribution 12 Even tumor patient,...

10.1055/s-2008-1032894 article EN RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren 1992-04-01
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