A5042746973- Enhanced Recovery After Surgery
- Cardiac, Anesthesia and Surgical Outcomes
- Pancreatic and Hepatic Oncology Research
- Nutrition and Health in Aging
- Gallbladder and Bile Duct Disorders
- Colorectal Cancer Surgical Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gastric Cancer Management and Outcomes
- PI3K/AKT/mTOR signaling in cancer
- Cutaneous Melanoma Detection and Management
- Pancreatitis Pathology and Treatment
- Bariatric Surgery and Outcomes
- Clinical practice guidelines implementation
- Hepatocellular Carcinoma Treatment and Prognosis
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Pediatric Hepatobiliary Diseases and Treatments
- Congenital Anomalies and Fetal Surgery
- Esophageal Cancer Research and Treatment
- Parasitic Infections and Diagnostics
- Parasitic infections in humans and animals
- Multiple and Secondary Primary Cancers
- Esophageal and GI Pathology
- Cancer Mechanisms and Therapy
- Hip and Femur Fractures
- Colorectal Cancer Treatments and Studies
University of Lausanne
2010-2024
Carolinas Medical Center
2023-2024
University Hospital of Lausanne
2011-2023
Weatherford College
2022
Assistance Publique – Hôpitaux de Paris
2021
Hôpitaux Universitaires Henri-Mondor
2021
Hôpital Orthopédique de la Suisse Romande
2013-2021
Pitié-Salpêtrière Hospital
2021
Sorbonne Université
2021
Hôpital du Valais
2016
Abstract Background Enhanced recovery protocols may reduce postoperative complications and length of hospital stay. However, the implementation these requires time financial investment. This study evaluated cost-effectiveness enhanced implementation. Methods The first 50 consecutive patients treated during an programme were compared with in year before its introduction. protocol principally implemented preoperative counselling, reduced fasting, carbohydrate loading, avoidance premedication,...
In Brief Objective: To compare epidural analgesia (EDA) to patient-controlled opioid-based (PCA) in patients undergoing laparoscopic colorectal surgery. Background: EDA is mainstay of multimodal pain management within enhanced recovery pathways [enhanced after surgery (ERAS)]. For resections, the benefit epidurals remains debated. Some consider as useful, whereas others perceive unnecessary or even deleterious. Methods: A total 128 elective resections were enrolled a randomized clinical...
Objective: The aim of this study was to compare clinical outcomes early versus delayed laparoscopic cholecystectomy (LC) in acute cholecystitis with more than 72 hours symptoms. Background: LC is the treatment cholecystitis, consensus recommendation that patients should be operated within evolution. Data however remain weak no prospective focusing on beyond Methods: Patients and symptoms were randomly assigned (ELC) or (DLC). ELC performed following hospital admission. DLC planned at least 6...
Abstract The mammalian target of rapamycin (mTOR), which exists in two functionally distinct complexes, mTORC1 and mTORC2 plays an important role tumor growth. Whereas the has been well characterized this process, little is known about functions cancer progression. In study, we explored specific colon using a short hairpin RNA expression system to silence mTORC2-associated protein rictor. We found that downregulation rictor HT29 LS174T cells significantly reduced cell proliferation....
Abstract Background Targeted therapies for metastatic renal cell carcinoma (RCC), including mammalian target of rapamycin (mTOR) inhibitors and small-molecule multikinase inhibitors, have produced clinical effects. However, most patients acquire resistance over time. Thus, new therapeutic strategies need to be developed. Here, we evaluated the effect dual PI3K/mTOR inhibitor NVP-BEZ235, in combination with sorafenib on cancer proliferation survival vitro as well tumor growth vivo . Methods...
Enhanced recovery after surgery (ERAS) protocols for elective colorectal reduce the intensity of postoperative complications, hospital stays and costs. Improvements in clinical outcome are directly proportional to adherence recommended pathway (compliance). The aim present study was analyze reasons non-compliance surgeries with ERAS protocol.A consecutive cohort patients undergoing prospectively analyzed regards surgery's compliance protocol. reason every single protocol deviation documented...
Abstract Background The mammalian target of rapamycin (mTOR) is frequently activated in colon cancers due to mutations the phosphatidylinositol 3-kinase (PI3K) pathway. Targeting mTOR with allosteric inhibitors such as reduces cancer progression several experimental models. Recently, a new class that act ATP-competitive mTOR, has been developed. effectiveness these drugs cells however not fully characterized. Methods LS174T, SW480 and DLD-1 cell lines were treated PP242 an inhibitor...
The aim of this study was to evaluate the different phases learning curve for robotic distal pancreatectomy (RDP) in international expert centers.
Abstract Background Multidisciplinary approach with adjuvant chemotherapy is the key element to provide optimal outcomes in pancreas and liver malignancies. However, post-operative complications may increase interval between surgery negative oncologic effects. Hypothesis study aim The of was analyse whether compliance Enhanced Recovery After Surgery (ERAS) pathway associated decreased chemotherapy. Methods Retrospective analysis all consecutive ERAS patients for hepatobiliary or pancreatic...