A5066273727- Pancreatic and Hepatic Oncology Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Cancer Genomics and Diagnostics
- Enhanced Recovery After Surgery
- Liver Disease Diagnosis and Treatment
- Gallbladder and Bile Duct Disorders
- Pancreatitis Pathology and Treatment
- Neuroendocrine Tumor Research Advances
- Gastric Cancer Management and Outcomes
- Ferroptosis and cancer prognosis
- Liver Disease and Transplantation
- Extracellular vesicles in disease
- Nutrition and Health in Aging
- Cancer, Lipids, and Metabolism
- Cancer-related molecular mechanisms research
- Organ Transplantation Techniques and Outcomes
- Esophageal and GI Pathology
- Colorectal Cancer Surgical Treatments
- Hemodynamic Monitoring and Therapy
- RNA modifications and cancer
- Metastasis and carcinoma case studies
- Viral-associated cancers and disorders
- Amoebic Infections and Treatments
University of Lausanne
2017-2025
University Hospital of Lausanne
2015-2024
Icahn School of Medicine at Mount Sinai
2014-2023
Hôpital Orthopédique de la Suisse Romande
2021
Hôpital de Morges
2019-2021
Printed Electronics (United Kingdom)
2019
Tisch Cancer Institute
2016
Polyclinic Medical University
2014
Abstract Clonal evolution of a tumor ecosystem depends on different selection pressures that are principally immune and treatment mediated. We integrate RNA-seq, DNA sequencing, TCR-seq SNP array data across multiple regions liver cancer specimens to map spatio-temporal interactions between cells. investigate how these reflect intra-tumor heterogeneity (ITH) by correlating regional neo-epitope viral antigen burden with the adaptive response. Regional expression passenger mutations dominantly...
Enhanced recovery after surgery (ERAS) programmes have been shown to decrease complications and hospital stay. The cost-effectiveness of such has demonstrated for colorectal surgery. This study aimed assess the economic outcomes a standard ERAS programme pancreaticoduodenectomy.ERAS pancreaticoduodenectomy was implemented in October 2012. All consecutive patients who underwent until 2014 were recorded. group compared terms costs with cohort between January 2010 2012, before implementation....
To test postoperative serum albumin drop (ΔAlb) as a marker of surgical stress response and early predictor clinical outcomes.Prospective cohort study (NCT02356484). Albumin was prospectively measured in 138 patients undergoing major abdominal surgery. Blood samples were collected before surgery on days 0, 1 2 3. ΔAlb compared to the modified estimation physiologic ability (mE-PASS) score correlated performances C reactive protein (CRP), procalcitonin (PCT) lactate (LCT). Postoperative...
Abstract Patients with hepatocellular carcinoma (HCC) release tumor cells to the bloodstream, which can be detected using cell surface markers. Despite numerous reports suggest a direct correlation between number of circulating (CTCs) and poor clinical outcomes, few studies have provided thorough molecular characterization CTCs. Due limited access tissue samples in patients at advanced stages HCC, it is crucial develop new technologies identify HCC cancer drivers routine conditions. Here, we...
Surveillance tools for early cancer detection are suboptimal, including hepatocellular carcinoma (HCC), and biomarkers urgently needed. Extracellular vesicles (EVs) have gained increasing scientific interest due to their involvement in tumour initiation metastasis; however, most extracellular RNA (exRNA) blood-based biomarker studies limited annotated genomic regions.
Introduction The amount of scientific data on liver surgery is exploding. There a critical unmet need to develop tools that will facilitate navigating the literature and offer easy, fast accurate access with high level evidence. Evidence maps (EM) combining living systematic reviews (SR) user-friendly synthesis graphs figures were developed for this purpose in other medical fields showed promising results but remain yet unavailable surgery. present study protocol aims generate an EM surgery,...