A5101782857- Nanopore and Nanochannel Transport Studies
- Advancements in Semiconductor Devices and Circuit Design
- Nanowire Synthesis and Applications
- Microfluidic and Bio-sensing Technologies
- Graphene research and applications
- Extracellular vesicles in disease
- Semiconductor materials and devices
- Microfluidic and Capillary Electrophoresis Applications
- MicroRNA in disease regulation
- Carbon Nanotubes in Composites
- RNA modifications and cancer
- Advanced biosensing and bioanalysis techniques
- Cancer-related molecular mechanisms research
- RNA Interference and Gene Delivery
- Quantum and electron transport phenomena
- Anodic Oxide Films and Nanostructures
- Diamond and Carbon-based Materials Research
- Advanced Memory and Neural Computing
- Advanced Proteomics Techniques and Applications
- Nanotechnology research and applications
- Circular RNAs in diseases
- Surface and Thin Film Phenomena
- Ferroelectric and Negative Capacitance Devices
- Photonic and Optical Devices
- Lattice Boltzmann Simulation Studies
IBM Research - Thomas J. Watson Research Center
2013-2021
IBM (United States)
2012-2021
Alliance for Safe Kids
2018-2019
Northeastern University
2013
Purdue University West Lafayette
2007-2011
Performance of graphene electronics is limited by contact resistance associated with the metal–graphene (M–G) interface, where unique transport challenges arise as carriers are injected from a 3D metal into 2D-graphene sheet. In this work, enhanced carrier injection experimentally achieved in devices forming cuts within regions. These oriented normal to channel and facilitate bonding between carbon atoms at cut edges, reproducibly maximizing "edge-contacted" injection. Despite reduction M–G...
Among the challenges hindering integration of carbon nanotube (CNT) transistors in digital technology are lack a scalable self-aligned gate and complementary n- p-type devices. We report CNT with gates scaled down to 20 nm ideal gate-all-around geometry. Uniformity wrapping channels is confirmed, process shown not damage CNTs. Further, both were realized by using appropriate dielectric-HfO2 yielded n-type Al2O3 p-type-with quantum simulations used explore impact important device parameters...
Extracellular vesicles (EVs) offer many opportunities in early-stage disease diagnosis, treatment monitoring, and precision therapy owing to their high abundance bodily fluids, accessibility from liquid biopsy, presence of nucleic acid protein cargo cell origin. Despite growing promise, isolation EVs for analysis remains a labor-intensive time-consuming challenge given nanoscale dimensions (30-200 nm) low buoyant density. Here, we report simple, size-based EV separation technology that...
The advent of microfluidics in the 1990s promised a revolution multiple industries from healthcare to chemical processing. Deterministic lateral displacement (DLD) is continuous-flow microfluidic particle separation method discovered 2004 that has been applied successfully and widely blood cells, yeast, spores, bacteria, viruses, DNA, droplets, more. conceptually simple can deliver consistent performance over wide range flow rates concentrations. Despite use in-depth study, DLD not yet fully...
Surveillance tools for early cancer detection are suboptimal, including hepatocellular carcinoma (HCC), and biomarkers urgently needed. Extracellular vesicles (EVs) have gained increasing scientific interest due to their involvement in tumour initiation metastasis; however, most extracellular RNA (exRNA) blood-based biomarker studies limited annotated genomic regions.
Significance Deterministic lateral displacement (DLD) is a technique for size fractionation of particles in continuous flow that has shown great potential biological and clinical applications. Several theoretical models have been proposed to explain the trajectories different-sized relation geometry pillar array, but experimental evidence demonstrated rich class intermediate migration behavior exists, which not predicted by models. In this work, we present unified framework infer trajectory...
Nanoscale deterministic lateral displacement (nanoDLD) is a microfluidic-based size separation technique allowing of subcellular biological particles such as double-stranded DNA and extracellular vesicles. Here, demonstration aggregation induced...
Previous measurements of the electronic conductance DNA nucleotides or amino acids have used tunnel junctions in which gap is mechanically adjusted, such as scanning tunneling microscopes controllable break junctions. Fixed-junction devices have, at best, detected passage whole molecules without yielding chemical information. Here, we report on a layered junction defined by dielectric layer, deposited atomic layer deposition. Reactive ion etching to drill hole through layers so that can be...
We studied the dsDNA trajectories being advected while diffusing in a pressure driven flow nanoDLD array.
We propose a novel low-power transistor device, called the broken-gap tunnel MOSFET (BG-TMOS), which is capable of achieving constant sub-60-mV/decade inverse subthreshold slopes S at room temperature. Structurally, device resembles an ungated heterostructure Esaki region in series with conventional MOSFET. The gate voltage independence energy spacing between conduction and valence bands heterojunction key to producing <; 60 mV/decade, can be tuned by properly engineering material...
As part of the genome-wide and chromosome-centric human proteomic project (C-HPP), we have integrated shotgun proteomics approach a transcriptomic (RNA-Seq) set colon cancer cell lines (LIM1215, LIM1899 LIM2405) that were selected to represent wide range pathological states colorectal cancer. The combination standard (1D-gel electrophoresis coupled LC/ion trap mass spectrometry) RNA-Seq allowed us exploit greater depth transcriptomics measurement (∼ 9800 transcripts per line) versus protein...
Utilizing nonequilibrium formation kinetics in porous anodic alumina (PAA) thin films, diamond and hybrid triangle-diamond pore patterns are achieved. During anodization, the self-compensation abilities of PAA allow diamond-shaped pores to form by omitting certain sites surface prepatterning process. The effects tessellation on cell these arrangements yield elongated, regular, partially compressed hexagonal structures leading diamond, circular, triangular pores, respectively. templates...
Appropriately controlling the properties of Si shell in Ge/Si core/shell nanowires permits not only passivation Ge surface states, but also introduces new interface phenomena, thereby enabling novel nanoelectronics concepts. Here, we report a rational synthesis with doped shells. We demonstrate that morphology and thickness shells can be controlled for different dopant types by tuning growth parameters during synthesis. present distinctly electrical characteristics arise from nanowire...
Effective DNA translocation into nanochannels is critical for advancing genome mapping and future single-molecule sequencing technologies. We present the design hydrodynamic study of a diamond-shaped gradient pillar array connected to enhancing success events. Single-molecule fluorescence imaging utilized interrogate interactions with this unique structure, evaluate key parameters, including speed, extension, time, provide detailed events in nanopillar arrays coupled 10 50 μm long channels....
While proven to provide high performance at sub-10 nm lengths, carbon nanotube (CNT) field-effect transistors (FETs) typically employ impractical gate geometries. Here we demonstrate fully self-aligned CNTFETs that include a gate-all-around (GAA) the channels - ideal geometry for 1D CNT. These GAA-CNTFETs have 30 channel lengths and exhibit n-type operation with on-currents good switching behavior is explained by quantum transport (NEGF) simulations. This work an important milestone showing...
Although there have been many reports of nanoparticle-decorated single-walled carbon nanotubes (SWCNTs), the morphology resulting nanoparticles has lacked consistency and control. The present work demonstrates a process for decorating SWCNTs with Pd that tendency toward selective distinct cubic shape. were synthesized from an embedded catalyst in porous anodic alumina (PAA) template. A single galvanostatic electrodeposition created nanowires contacted within pores decorated above surface...
Abstract Nanoscale deterministic lateral displacement (nanoDLD) has emerged as an effective method for separating nanoscopic colloids applications in molecular biology, yet present limits throughput, purification, on‐chip filtration, and workflow restricting its adoption a practical separation technology. To overcome these impediments, array scaling parallelization integrated nanoDLD ( i ‐nanoDLD) enrichment devices are developed to achieve density of ≈83 arrays mm −2 with 31 160 parallel...
Two-dimensional (2D) nanomaterials have been of intense interest in recent years because their exceptional electronic, thermal, and mechanical properties. Tailoring these novel properties toward intrinsic potential requires precise control the atomic layer growth process underlying catalytic substrate, as morphology purity surface plays a critical role on shape, size, kinetics 2D nanomaterial. In this work, we present systematic study interface subsequent carrier mobility CVD-grown graphene....
Abstract Circulating extracellular vesicles (EVs) present in the bodily fluids of patients with cancer may provide non-invasive access to tumor tissue. Yet, transcriptomic lineage tumor-derived EVs before and after tumor-resection remains poorly understood. Here, we established 60 total small RNA-sequencing profiles from 17 aggressive prostate (PCa) patient’s adjacent normal tissue, isolated urine, serum, cell culture media. We interrogated key satellite alteration found that resection...
This paper discusses effects of nanoscale contacts to silicon nanowires on contact resistance. The widely used transmission line model (TLM), which treats the semiconductor as an infinitely thin layer, can only predict resistance by assuming a dynamically varying resistivity. ρ <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">c</sub> values must be experimentally obtained for each length, rendering predictive capabilities TLM inadequate beyond...
The mechanical properties of stacked graphene sheets with varying number layers are examined. assembled by manually combining single layer CVD-grown monolayers, resulting in a turbostratic multilayer irregular spacing greater than crystalline graphite. Due to the presence multiple layers, material is analyzed as plate rather membrane. Bending stiffness determined via deflection micron-scale cantilevers, prepared using focused ion beam milling, while in-plane tensile characterized through...
ABSTRACT Background Hepatocellular carcinoma (HCC) is among the deadliest malignancies and surveillance tools for early detection are suboptimal. Extracellular vesicles (EVs) have gained increasing scientific interest due to their involvement in tumor initiation metastasis, however, most extracellular RNA (exRNA) biomarker studies limited annotated genomic regions. Methods EVs were isolated with ultracentrifugation nanoDLD quality assessed by electron microscopy, immunoblotting, nanoparticle...