A5062134753- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Mechanisms and Therapy
- Pancreatic and Hepatic Oncology Research
- Gallbladder and Bile Duct Disorders
- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- Peptidase Inhibition and Analysis
- MRI in cancer diagnosis
- Liver Disease and Transplantation
- Liver physiology and pathology
- Advanced Breast Cancer Therapies
- Galectins and Cancer Biology
- Hepatitis B Virus Studies
- Neuroendocrine Tumor Research Advances
- Ubiquitin and proteasome pathways
- Pediatric Hepatobiliary Diseases and Treatments
- Genetic factors in colorectal cancer
- RNA modifications and cancer
- Hippo pathway signaling and YAP/TAZ
- Sarcoma Diagnosis and Treatment
- PI3K/AKT/mTOR signaling in cancer
- Medical Imaging and Pathology Studies
- Tuberous Sclerosis Complex Research
University of Regensburg
2015-2024
University Hospital Regensburg
2015-2024
Federico II University Hospital
2022
Universitätsmedizin Greifswald
2013-2020
Klinikum Region Hannover
2019
Universität Greifswald
2013-2017
Klinik für Frauenheilkunde
2014
Cholangiocarcinoma (CCA) is a rare and heterogeneous biliary cancer, whose incidence related mortality increasing. This study investigates the clinical course of CCA subtypes (intrahepatic [iCCA], perihilar [pCCA], distal [dCCA]) in pan-European cohort.The ENSCCA Registry multicenter observational study. Patients were included if they had histologically proven diagnosis between 2010-2019. Demographic, histomorphological, biochemical, studies performed.Overall, 2,234 patients enrolled...
Objective Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer with limited treatment options. Cabozantinib, an orally bioavailable multikinase inhibitor now approved by Food and Drug Administration (FDA) for HCC patients. We evaluated therapeutic efficacy cabozantinib, either alone or in combination, vitro vivo. Design Human cell lines mouse models were used to assess targeted molecular pathways combination pan-mTOR MLN0128 checkpoint anti-PD-L1 antibody. Results...
Pregnancy hides an immunological riddle combining two antagonistic characteristics of immunology: the existence a tolerance that allows gestation semiallogeneic fetus and proper protection against pathogens threatening health immunocompromised mother. Despite fundamental role B cells play in orchestrating immune response, their behavior context pregnancy has been barely investigated. Here we demonstrate numbers pre/pro immature were progressively diminished bone marrow (BM) pregnant mice,...
Gadolinium ethoxybenzyl-diethylenetriaminepentaacetic acid (Gd-EOB-DTPA) is a hepatocyte-specific MRI contrast agent. Because the hepatic uptake of Gd-EOB-DTPA depends on integrity hepatocyte mass, this can be quantified to assess liver function. We report relationship between extent and degree fibrosis. T1-weighted volume-interpolated breath-hold examination (VIBE) sequences with fat suppression were acquired before 20 minutes after injection. Strong correlations characteristics relative...
Abstract Mutations and activation of the PI3K signaling pathway in breast cancer cells have been linked to brain metastases. However, here we describe that some metastases samples protein expression components is restricted metastatic microenvironment. In contrast therapeutic effects inhibition on cells, reaction microenvironment less understood. Therefore aimed quantify activity metastasis investigate central nervous system (CNS) First, systematically metastases, performed a prospective...
// Xiaolei Li 1,2 , Junyan Tao 2,3 Antonio Cigliano 4 Marcella Sini Julien Calderaro 5,6 Daniel Azoulay 7 Chunmei Wang 2 Yan Liu 1 Lijie Jiang Katja Evert Maria I. Demartis 8 Silvia Ribback Kirsten Utpatel Frank Dombrowski Matthias Diego F. Calvisi 4,8 and Xin Chen Department of Hepatobiliary Surgery, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shaanxi, P.R. China Bioengineering Therapeutic Sciences Liver Center, University California, San Francisco, CA, U.S.A 3 School...
Intrahepatic cholangiocarcinoma (ICC) is an aggressive cancer type, lacking effective therapies and associated with a dismal prognosis. Palbociclib selective CDK4/6 inhibitor, which has been shown to suppress cell proliferation in many experimental models. Recently, we demonstrated that pan-mTOR inhibitors, such as MLN0128, effectively induce apoptosis, although have limited efficacy restraining of ICC cells. Here, tested the hypothesis palbociclib, due its antproliferative properties types,...
Background and Aims Intrahepatic cholangiocarcinoma (iCCA) with liver metastases is perceived to have a poor prognosis, but the American Joint Committee on Cancer (AJCC) classifies them as early stage in absence of lymph nodes or extrahepatic spread. Approach Results Patients iCCA from European Network for Study Cholangiocarcinoma (ENS‐CCA) Surveillance, Epidemiology, End (SEER) registries survival/staging (AJCC v.7) data were eligible. Modified staging was used (mAJCC v.7): group A: stages...
Fibrosis is a major component of chronic cardiac allograft rejection. Although several cell types are able to produce collagen, resident (donor-derived) fibroblasts mainly responsible for excessive production extracellular matrix proteins. It currently unclear which cells regulate connective tissue elements in fibrosis and how basophils, as potential producers profibrotic cytokines, involved this process. We studied question fully MHC-mismatched model heart transplantation with transient...
Prostate cancer is one of the leading causes mortality in men worldwide. An unusual but unique environment for studying tumor cell processes provided by microgravity, either space or simulated ground-based devices like a random positioning machine (RPM). In this study, prostate adenocarcinoma-derived PC-3 cells were cultivated on an RPM time periods 3 and 5 days. We investigated genes associated with cytoskeleton, focal adhesions, extracellular matrix, growth, survival, angiogenesis,...
Multiple Myeloma (MM) is an incurable plasma cell malignancy primarily localized within the bone marrow (BM). It develops from a premalignant stage, monoclonal gammopathy of undetermined significance (MGUS), often via intermediate smoldering MM (SMM). The mechanisms progression have not yet been fully understood, all more because patients with MGUS and SMM already carry similar initial mutations as found in cells. Over last years, increased importance has attributed to tumor microenvironment...
Intrahepatic cholangiocarcinoma (iCCA) is a highly aggressive primary liver tumor with increasing incidence worldwide, dismal prognosis, and few therapeutic options. Mounting evidence underlines the role of Hippo pathway in this disease; however, molecular mechanisms whereby cascade contributes to cholangiocarcinogenesis remain poorly defined.We established novel iCCA mouse models via hydrodynamic transfection an activated form transcriptional coactivator PDZ-binding motif (TAZ), downstream...
Abstract Gd-EOB-DTPA, a liver-specific contrast agent with T1-shortening effects, is routinely used in clinical routine for detection and characterization of focal liver lesions has recently received increasing attention as tool the quantitative analyses function. We report relationship between extent Gd-EOB-DTPA- induced T1 relaxation degree fibrosis, which was assessed according to METAVIR score. For relaxometry, transverse 3D VIBE sequence inline calculation acquired prior 20 minutes...
The aim of this study was to assess the value 18F-FDG PET/CT for quantitative assessment hepatic metabolism in patients with different stages liver fibrosis/cirrhosis. scans 37 either or without fibrosis/cirrhosis, classified according METAVIR score (F0-F4) obtained from histopathological analysis specimen, were analyzed retrospectively and as follows: no fibrosis (F0, n = 6), mild (F1, 11), advanced (F2, severe (F3, 5), cirrhosis (F4, 11). liver-to-blood ratio (LBR, scan time corrected a...
More than half of all brain metastases show infiltrating rather displacing growth at the macro-metastasis/organ parenchyma interface (MMPI), a finding associated with shorter survival. The lymphoid enhancer-binding factor-1 (LEF1) is an epithelial-mesenchymal transition (EMT) transcription factor that commonly overexpressed in brain-colonizing cancer cells. Here, we LEF1 vivo breast colonization model. It shortened survival, albeit without engaging EMT MMPI. By differential proteome...
Abstract Hepatocellular carcinoma (HCC) is the major type of primary liver cancer. Genomic studies have revealed that HCC a heterogeneous disease with multiple subtypes. BRG1, encoded by SMARCA4 gene, key component SWI/SNF chromatin-remodeling complexes. Based on TCGA studies, somatic mutations occur in ~3% human samples. Additional suggest BRG1 overexpressed specimens and may promote growth invasion. However, precise functional roles remain poorly delineated. Here, we analyzed samples as...
Abstract Objectives The present study evaluated the predictive value of staging and grading parameters concerning presence lymph-node metastases, overall survival (OS), relapse-free (RFS) patients with oral squamous cell carcinoma (OSCC). Materials methods HE-stains 135 surgically treated (R0) primary OSCCs were analyzed using a both microscopic software-based approach. Depth invasion (DOI) resection margins (RM) measured, each case was graded according to malignancy system as described by...
Background: Lymph node metastasis and positive resection margins have been reported to be major determinants of overall survival (OS) poor recurrence-free (RFS) for patients who underwent perihilar cholangiocarcinoma (pCCA). However, the prognostic value lymph nodes independently from margin status on OS has not evaluated. Methods: From European Cholangiocarcinoma (ENSCCA) registry, pCCA between 1994 2021 were included in this retrospective cohort study. The primary outcome was stratified...
// Salvatore Delogu 1,* , Chunmei Wang 2,* Antonio Cigliano 1 Kirsten Utpatel Marcella Sini Thomas Longerich 3 Nina Waldburger Kai Breuhahn Lijie Jiang 2 Silvia Ribback Frank Dombrowski Matthias Evert Xin Chen and Diego F. Calvisi Institut für Pathologie, Universitätsmedizin Greifswald, Germany Department of Bioengineering Therapeutic Sciences Liver Center, University California, San Francisco, CA Institute Pathology, Hospital Heidelberg, * These authors contributed equally to this work...