A5049636361- Neuroinflammation and Neurodegeneration Mechanisms
- Extracellular vesicles in disease
- HIV Research and Treatment
- CNS Lymphoma Diagnosis and Treatment
- Rheumatoid Arthritis Research and Therapies
- Drug-Induced Adverse Reactions
- Trauma and Emergency Care Studies
- Esophageal Cancer Research and Treatment
- Hemostasis and retained surgical items
- Metastasis and carcinoma case studies
- Intestinal and Peritoneal Adhesions
- Esophageal and GI Pathology
- Cytomegalovirus and herpesvirus research
- Viral-associated cancers and disorders
- Teratomas and Epidermoid Cysts
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Neuroendocrine Tumor Research Advances
- Foreign Body Medical Cases
- Gastrointestinal disorders and treatments
- Gastroesophageal reflux and treatments
- Sarcoidosis and Beryllium Toxicity Research
- Gastric Cancer Management and Outcomes
- Clinical Nutrition and Gastroenterology
- Abdominal vascular conditions and treatments
- Colorectal Cancer Screening and Detection
University of Minnesota
2021
University of Nebraska Medical Center
2015-2020
Malteser Waldkrankenhaus Erlangen
2017-2020
University Medical Center Freiburg
2011
HIV-1-infected and/or immune-activated microglia and macrophages are pivotal in the pathogenesis of HIV-1-associated neurocognitive disorders (HAND). Glutaminase, a metabolic enzyme that facilitates glutamate generation, is upregulated may play pathogenic role HAND. Our previous studies have demonstrated glutaminase released to extracellular fluid during HIV-1 infection neuroinflammation. However, key molecular mechanisms regulate release remain unknown. Recent advances understanding...
Extracellular vesicles (EVs) are important in the intercellular communication of central nervous system, and their release is increased during neuroinflammation. Our previous data demonstrated an EVs HIV-1 infection immune activation glial cells. However, molecular mechanism by which inflammation increase EV remains unknown. In current study, we investigated role glutaminase 1 (GLS1)-mediated glutaminolysis production a key metabolic intermediate α-ketoglutarate on release. Human...
Abstract Background The year 2020 presented the transfusion community with unprecedented events and challenges, including ongoing SARS‐CoV‐2 (COVID‐19) pandemic, more recently by civil unrest, following death of George Floyd in late May 2020. As a level 1 trauma center located Minneapolis, Minnesota, Hennepin Healthcare (HCMC) offers unique perspective into changes massive protocol (MTP) activations usage during this tumultuous period. This may provide insight for addressing similar future...
Sarcoidosis can involve any of the organs, however intraosseous involvement is rare and ranges from 5 to 15%, with lesions mandible being even rarer – currently few known cases reported. Intraosseous involving have been noted be asymptomatic or associated chronic jaw pain. Additionally, mandibular present as a lytic bone lesion mimicking osseous malignancy. Chronic polyarthritis commonly progression sarcoidosis has considered late-stage sequelae. We report case biopsy-proven within condyle...
A 56-year-old man with HIV on combination antiretroviral therapy (CD4 count 368 cells/μL; HIV-RNA < 20 copies/mL) had sequential, bilateral oculomotor nerve palsy after recent travel to Africa. Nonexpansile enhancement of the nerves was noted MRI (figure 1). Multiple CSF studies showed lymphocytic pleocytosis without neoplastic cells. Molecular testing serum positive for Plasmodium falciparum by PCR early in course presentation but symptoms progressed despite treatment P . Infectious...
Abstract A 75-year-old man presented with bleeding ileostomy stoma 20 years after total colectomy and end for chronic ulcerative colitis. On physical examination, the was mass-like firm friable mucosa. Wedge biopsy of revealed well-differentiated neuroendocrine tumor (intermediate grade). 68 Ga-DOTATATE PET/CT showed focal radiotracer uptake at site without radiotracer-avid lymphadenopathy or distant metastatic disease. No additional sites neoplasm in gastrointestinal tract were further...
Die endoskopische transmurale Vollwandresektion (EFTR) erweitert das Resektionsspektrum, indem diese Methode die Resektion von Läsionen erlaubt, keine Abhebung der Mukosa zeigen (Rezidivadenome, Infiltration), submukös liegen oder bereits ein Mukosakarzinom beinhalten.
A 61 yr old woman was admitted to the emergency department due nausea and weakness for 1 week without any improvement on proton pump inhibitors. She denied vomiting, pain, stool abnormality, cough, fever or dysuria; she negative Covid-19 risk stratification respiratory/infectious symptoms, contact persons physical examination [1].