A5075026411- Immune Cell Function and Interaction
- Organ Transplantation Techniques and Outcomes
- Pancreatic and Hepatic Oncology Research
- Liver Disease and Transplantation
- T-cell and B-cell Immunology
- Liver Disease Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Gallbladder and Bile Duct Disorders
- Hepatocellular Carcinoma Treatment and Prognosis
- Abdominal Surgery and Complications
- Pancreatitis Pathology and Treatment
- Clinical Nutrition and Gastroenterology
- Surgical site infection prevention
- Cancer Immunotherapy and Biomarkers
- IL-33, ST2, and ILC Pathways
- Colorectal Cancer Treatments and Studies
- Renal cell carcinoma treatment
- COVID-19 and healthcare impacts
- Ultrasound Imaging and Elastography
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Ultrasound and Hyperthermia Applications
- Hernia repair and management
- Cytomegalovirus and herpesvirus research
- Biosimilars and Bioanalytical Methods
- Diagnosis and Treatment of Venous Diseases
University Hospital Regensburg
2015-2025
Klinik und Poliklinik für Kinder- und Jugendmedizin
2023
LMU Klinikum
2016
Ludwig-Maximilians-Universität München
2016
University of Regensburg
2014-2015
Universität Innsbruck
2014
Kantonsspital Graubünden
2014
Austrian Academy of Sciences
2008-2012
Kantonsspital Baselland Standort Bruderholz
2012
Deggendorf Institute of Technology
2008
Aging is a multifactorial process where deterioration of body functions driven by stochastic damage while counteracted distinct genetically encoded repair systems. To better understand the genetic component aging, many studies have addressed gene and protein expression profiles various aging model systems engaging different organisms from yeast to human. The recently identified small non-coding miRNAs are potent post-transcriptional regulators that can modify up several hundred target genes...
Interleukin‐33 (IL‐33), a cytokine with pleiotropic functions, is elevated in serum of patients hepatocellular carcinoma (HCC). This study investigated the effects local IL‐33 expression resected HCC on patient survival and immunological molecular tumor microenvironment. Tissue HCCs was stained for hematoxylin eosin, Masson trichrome, alpha‐smooth muscle actin, IL‐33, CD8, IL‐13 analyzed by flow cytometry. Besides histomorphologic evaluation, immunohistochemical stainings were respective...
Abstract Recently, a key role in memory T cell homing and survival has been attributed to the bone marrow (BM) mice. In human BM, repertoire, function, niches of CD4+ CD8+ cells have not yet elucidated. this study, we demonstrate that effector accumulate BM are heightened activation state as revealed by CD69 expression. BM-resident produce more IFN-γ frequently polyfunctional. Immunofluorescence analysis immediate vicinity IL-15–producing cells, suggesting close interaction between these two...
The life-long homeostasis of memory CD8(+) T cells as well persistent viral infections have been shown to facilitate the accumulation highly differentiated CD28(-) cells, a phenomenon that has associated with an impaired immune function in humans. However, molecular mechanisms regulating not yet elucidated. In this study, we demonstrate miR-23∼24∼27 cluster is up-regulated during post-thymic T-cell differentiation increased expression miR-24 decreased histone variant H2AX, protein plays key...
Abstract Background ALPPS is found to increase the resectability of primary and secondary liver malignancy at advanced stage. The aim study was verify surgical oncological outcome for intrahepatic cholangiocarcinoma (ICC). Methods cohort based on registry with patients from 31 international centers between August 2009 January 2018. Propensity score matched receiving chemotherapy only were selected SEER database as controls survival analysis. Results One hundred two undergoing recruited, 99...
Abstract Background Liver metastases occur in 40–50 per cent of patients with colorectal cancer and determine long-term survival. The aim this study was to examine the immunological architecture liver its impact on patient Methods Specimens from were stained haematoxylin eosin Masson trichrome, immunostained for α-smooth muscle actin, CD4, CD45RO CD8, analysed by flow cytometry. In addition histomorphological evaluation, immunohistochemically sections cell numbers tumour area, infiltrative...
Abstract Patient-derived xenografts (PDXs) provide biologically relevant models and potential platforms for the development of treatment strategies precision medicine in pancreatic cancer. Furthermore, circulating epithelial tumor cells (CETCs/CTCs) are released into bloodstream by solid tumors a rare subpopulation—circulating cancer stem (cCSCs) – is considered to be responsible recurrence plays key role metastasis. For identification cCSCs, an innovative vitro assay generate tumorspheres...
To identify new genetic regulators of cellular aging and senescence, we performed genome-wide comparative RNA profiling with selected human model systems, reflecting replicative stress-induced premature distinct other forms aging. Gene expression profiles were measured, analyzed, entered into a newly generated database referred to as the GiSAO database. Bioinformatic analysis revealed set candidate genes, conserved across majority models, which so far not associated aging, highlighted...
GRAPHICAL ABSTRACTPeritoneal carcinomatosis of colorectal cancer is characterized by structural and functional reorganization the tumor microenvironment inducing senescence proliferation arrest in cellsAll authorsCaroline Theresa Seebauer, Stefan Brunner, Gabriel Glockzin, Pompiliu Piso, Petra Ruemmele, Hans-Juergen Schlitt, Edward Kenneth Geissler, Fichtner-Feigl & Rebecca Kesselringhttps://doi.org/10.1080/2162402X.2016.1242543Published online:29 November 2016Illustration 1. Overview immune...
The aim of this study was to assess the value 18F-FDG PET/CT for quantitative assessment hepatic metabolism in patients with different stages liver fibrosis/cirrhosis. scans 37 either or without fibrosis/cirrhosis, classified according METAVIR score (F0-F4) obtained from histopathological analysis specimen, were analyzed retrospectively and as follows: no fibrosis (F0, n = 6), mild (F1, 11), advanced (F2, severe (F3, 5), cirrhosis (F4, 11). liver-to-blood ratio (LBR, scan time corrected a...
Allograft fibrosis still remains a critical problem in transplantation, including heart transplantation. The IL-13/TGF-β1 interaction has previously been identified as key pathway orchestrating different inflammatory immune disorders. Here we investigate if this is also responsible for allograft and interference with the prevents fibrosis.FVB or control DBA/1 donor hearts were transplanted heterotopically into recipient mice explanted at day 60 100 post-transplantation. Cardiac tissue was...
The immunological microenvironment of HCC influences patient outcome, however, the role B cells remains unclear. This study investigated effects local B-cell infiltration in cohorts on survival and molecular tumor microenvironment.Unsupervised gene expression analysis full cancer transcriptomes (N=2158) revealed a highly co-regulated cluster that mainly contained immunoglobulin fragments. More specifically, an independent cohort (N=242) compares with non tumorous liver tissue high these...
Abstract Spontaneous amelioration of inflammation (often accompanied by fibrosis) is a well-known, but poorly understood, outcome many chronic inflammatory processes. We studied this phenomenon in trinitrobenzene sulfonic acid–induced colitis model, an experimental mice that we showed to ultimately undergo spontaneous resolution, despite continued acid stimulation. Analysis the mechanism resolution revealed it was critically dependent on IL-13 activation STAT6, followed phosphorylation...
This study was performed to assess the 2006 introduced ENETS TNM-classification with respect patient survival and surgical approach for patients who underwent surgery a neuroendocrine tumor of pancreas (PNET).Between 2001 2010 38 after resection PNET were investigated regarding localization size. Further, regards new TNM-classification, operation methods immunohistochemical markers analyzed.The estimated mean time 91 ± 10 months (female 116 9, male 56 14 months; p = 0.008). The 5-year rate...