A5048961414- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Pancreatic and Hepatic Oncology Research
- Ovarian cancer diagnosis and treatment
- Gastric Cancer Management and Outcomes
- Cancer Genomics and Diagnostics
- Cancer-related molecular mechanisms research
- Pediatric Hepatobiliary Diseases and Treatments
- Colorectal Cancer Treatments and Studies
- Intraperitoneal and Appendiceal Malignancies
- Synthetic Aperture Radar (SAR) Applications and Techniques
- Genetic factors in colorectal cancer
- Soil Moisture and Remote Sensing
- Viral-associated cancers and disorders
- Anesthesia and Pain Management
- Esophageal Cancer Research and Treatment
- Neuroscience and Neuropharmacology Research
- Endometrial and Cervical Cancer Treatments
- Anesthesia and Sedative Agents
- MicroRNA in disease regulation
- Wave and Wind Energy Systems
- Esophageal and GI Pathology
- Radiomics and Machine Learning in Medical Imaging
- Advanced SAR Imaging Techniques
- Cancer Diagnosis and Treatment
Memorial Sloan Kettering Cancer Center
2018-2025
InertialWave (United States)
2025
RELX Group (United States)
2024
Faculty of 1000 (United States)
2024
University of Tampa
2024
University of Oxford
2013-2022
Ocean Power Technologies (United States)
2022
Cornell University
2020
NeuroRx Research (Canada)
2018
Vrije Universiteit Amsterdam
2018
<h3>Importance</h3> Unresectable intrahepatic cholangiocarcinoma (IHC) carries a poor prognosis, with median overall survival (OS) of 11 months. Hepatic arterial infusion (HAI) high-dose chemotherapy may have potential benefit in these patients. <h3>Objective</h3> To evaluate clinical outcomes when HAI is combined systemic patients unresectable IHC. <h3>Design, Setting, and Participants</h3> A single-institution, phase 2 trial including 38 was conducted floxuridine plus gemcitabine...
Genetic alterations in intrahepatic cholangiocarcinoma (iCCA) are increasingly well characterized, but their impact on outcome and prognosis remains unknown.This bi-institutional study of patients with confirmed iCCA (n = 412) used targeted next-generation sequencing primary tumors to define associations among genetic alterations, clinicopathological variables, outcome. The most common oncogenic were isocitrate dehydrogenase 1 (IDH1; 20%), AT-rich interactive domain-containing protein 1A...
Objective: To analyze clinical outcomes and prognostic variables of patients undergoing hepatic resection for BRAF mutant ( -mut) colorectal liver metastases (CRLM). Background: Outcomes following hepatectomy -mut CRLM have not been well studied. Methods: All who underwent with complete known status during 2001 to 2016 at 3 high-volume centers were analyzed. Results: Of 4124 CRLM, 1497 had status. Thirty-five (2%) -mut, 71% V600E mutation. Compared wild-type -wt), older, more commonly...
Intrahepatic cholangiocarcinomas are histologically heterogenous. Using a cohort of 184 clinically defined, resected intrahepatic cholangiocarcinomas, we retrospectively classified the histology into 4 subtypes: large duct (LD), small (SD) (predominantly tubular [SD1] or predominantly anastomosing/cholangiolar, [SD2]), indeterminate. Then, tested subtypes for associations with risk factors, patient outcomes, histology, and immunophenotypic characteristics. SD was most common (84%; 24% SD1...
The liver is a frequent site of benign and malignant, primary metastatic tumors. Hepatocellular carcinoma (HCC) intrahepatic cholangiocarcinoma (ICC) are the most common cancers, colorectal metastasis (CRLM) secondary cancer. Although imaging characteristic these tumors central to optimal clinical management, it relies on features that often non-specific, overlap, subject inter-observer variability. Thus, in this study, we aimed categorize automatically from CT scans using deep learning...
To investigate a possible connection between erythromycin administration and reduced elimination of alfentanil, controlled crossover study alfentanil pharmacokinetics was undertaken. Six subjects were monitored for plasma levels 8 hours after administered. These measurements obtained 0-, 1-, 7-day course erythromycin. Elimination half-life increased significantly (p < 0.01) 7 days from the control value 84.0 ± 8.2 minutes to 131.4 43.5 minutes. Clearance decreased 0.05) 3.9 0.8 ml/kg/min 2.9...
Abstract Background Liver metastases occur in 40–50 per cent of patients with colorectal cancer and determine long-term survival. The aim this study was to examine the immunological architecture liver its impact on patient Methods Specimens from were stained haematoxylin eosin Masson trichrome, immunostained for α-smooth muscle actin, CD4, CD45RO CD8, analysed by flow cytometry. In addition histomorphological evaluation, immunohistochemically sections cell numbers tumour area, infiltrative...
Abstract The NMDA receptor-mediated Ca 2+ signaling during simultaneous pre- and postsynaptic activity is critically involved in synaptic plasticity thus has a key role the nervous system. In GRIN2 -variant patients alterations of this coincidence detection provoked complex clinical phenotypes, ranging from reduced muscle strength to epileptic seizures intellectual disability. By using our gene-targeted mouse line (Grin2a N615S ) , we show that voltage-independent glutamate-gated...
Lymph node metastasis (LNM) drastically reduces survival after resection of intrahepatic cholangiocarcinoma (IHC). Optimal treatment is ill defined, and it unclear whether tumor mutational profiling can support decisions.Patients with liver-limited IHC or without LNM treated (N = 237), hepatic arterial infusion chemotherapy (HAIC; N 196), systemic alone (SYS; 140) at our institution between 2000 2018 were included. Genomic sequencing was analyzed to determine genetic alterations could...
<h3>Importance</h3> In patients with resectable colorectal cancer liver metastases (CRLM), the choice of surgical technique and resection margin are only variables that under surgeon's direct control may influence oncologic outcomes. There is currently no consensus on optimal width. <h3>Objective</h3> To determine width in CRLM by using artificial intelligence–based techniques developed Massachusetts Institute Technology to assess whether should be individualized based patient...
Objective: Evaluate an electronic platform for remote symptom monitoring to enhance postdischarge care in thoracic surgery using patient reporting of symptoms. Summary Background Data: Owing the increased use enhanced recovery after protocols, patients are spending a larger portion their postoperative course at home. For undergoing complex operations, this represents opportunity early identification abnormal symptoms home before deterioration. Methods: An online symptom-tracking was created...
Objective: To investigate the clinical implications of BRAF -mutated (mut ) colorectal liver metastases (CRLMs). Background: The mut status in CRLMs are largely unknown. Methods: Patients undergoing resection for CRLM were identified from prospectively maintained registries collaborating institutions. Overall survival (OS) and recurrence-free (RFS) compared among patients with V600E versus non-V600E mutations, KRAS/BRAF comutation alone, microsatellite stability (Microsatellite Stable (MSS)...