A5071951173- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Neuroendocrine Tumor Research Advances
- Cancer Cells and Metastasis
- Gallbladder and Bile Duct Disorders
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Research and Treatments
- Cell death mechanisms and regulation
- Cancer Genomics and Diagnostics
- Gastric Cancer Management and Outcomes
- Phagocytosis and Immune Regulation
- Gastrointestinal disorders and treatments
- Colorectal Cancer Screening and Detection
- Gastrointestinal Tumor Research and Treatment
- Multiple and Secondary Primary Cancers
- Pediatric Hepatobiliary Diseases and Treatments
- Bariatric Surgery and Outcomes
- 3D Printing in Biomedical Research
- Epigenetics and DNA Methylation
- Hepatocellular Carcinoma Treatment and Prognosis
- Oral and Maxillofacial Pathology
- Cardiac, Anesthesia and Surgical Outcomes
- Renal cell carcinoma treatment
- Hedgehog Signaling Pathway Studies
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
Diakonissenkrankenhaus
2022-2025
University Medical Centre Mannheim
2015-2024
Heidelberg University
2015-2024
University Hospital Heidelberg
2015-2024
Medizinische Fakultät Mannheim
2021
University of Mannheim
2012-2018
University Hospital Carl Gustav Carus
2008-2017
DKFZ-ZMBH Alliance
2017
German Cancer Research Center
2017
Johannes Gutenberg University Mainz
2004-2015
Pancreatic ductal adenocarcinoma (PDA) is among the most lethal human cancers in part because it insensitive to many chemotherapeutic drugs. Studying a mouse model of PDA that refractory clinically used drug gemcitabine, we found tumors this were poorly perfused and vascularized, properties are shared with PDA. We tested whether delivery efficacy gemcitabine mice could be improved by coadministration IPI-926, depletes tumor-associated stromal tissue inhibition Hedgehog cellular signaling...
Predicting the clinical outcome of cancer patients based on expression marker genes in their tumors has received increasing interest past decade. Accurate predictors and response to therapy could be used personalize thereby improve therapy. However, state art methods so far often found with limited prediction accuracy, reproducibility, unclear biological relevance. To address this problem, we developed a novel computational approach identify prognostic for that couples gene measurements from...
In Brief Objective: To investigate different subtypes of intraductal papillary mucinous neoplasms (IPMNs) the pancreas and their prognostic value. Background: IPMNs are estimated to have a better prognosis than pancreatic ductal adenocarcinomas (PDACs). addition growth types (ie, main duct vs. branch types), histological intestinal, pancreatobiliary, gastric, oncocytic type) prognostically relevant. These can be characterized by mucin (MUC) expression patterns. this study, we analyzed from 2...
In pancreatic cancer, the incidence and mortality curves coincide. One major reason for this high rate in ductal adenocarcinoma (PDAC) patients is dearth of effective diagnostic, prognostic, disease-monitoring biomarkers. Unfortunately, existing tumor markers, as well current imaging modalities, are not sufficiently sensitive and/or specific early-stage diagnosis. There is, therefore, an urgent need improved serum markers disease. Herein, we performed Orbitrap® mass spectrometry proteomic...
Importance The effect of adjuvant chemotherapy following resection pancreatic adenocarcinoma after preoperative (m)FOLFIRINOX (combination leucovorin calcium [folinic acid], fluorouracil, irinotecan hydrochloride, and oxaliplatin in full or modified dosing) on overall survival (OS) is unclear because current studies do not account for the number cycles regimen. Objective To investigate association with OS, taking into Design, Setting, Participants This retrospective cohort study included...
Bacterial outer membrane vesicles (OMVs) are promising as antitumour agents, but their clinical application is limited by toxicity concerns and unclear mechanisms. We engineered OMVs with cadherin 17 (CDH17) tumour-targeting nanobodies, enhancing tumour selectivity efficacy while reducing adverse effects. These function natural stimulator of interferon genes (STING) agonists, activating the cyclic GMP-AMP synthase (cGAS)-STING pathway in cancer cells tumour-associated macrophages (TAMs)....
Pancreatic cancer is one of the leading causes cancer-related deaths, for which serological biomarkers are urgently needed. Most discovery-phase studies focus on use biological source analysis. The present study details combined mining pancreatic cell line conditioned media and juice identification putative diagnostic leads. Using strong cation exchange chromatography, followed by LC-MS/MS an LTQ-Orbitrap mass spectrometer, we extensively characterized proteomes from six lines (BxPc3,...
Abstract Pancreatic ductal adenocarcinoma (PDAC) is characterized by an abundant desmoplastic stroma. Interactions between cancer and stromal cells play a critical role in tumour invasion, metastasis chemoresistance. Therefore, we hypothesized that gene expression profile of the components pancreatic carcinoma different from chronic pancreatitis reflects interaction with tumour. We investigated eleven tissues PDAC, nine cell lines origin using Affymetrix U133 GeneChip set. The tissue samples...
Objective response rates to standard chemotherapeutic regimens remain low in pancreatic cancer. Subpopulations of cells have been identified various solid tumors which express stem cell-associated markers and are associated with increased resistance against radiochemotherapy. We investigated the expression cell genes epithelial-mesenchymal transition cancer that survived high concentrations gemcitabine treatment. Capan-1 Panc-1 were continuously incubated 1 10 µM gemcitabine. Surviving...
Abstract Extracellular vesicles secreted from adipose‐derived mesenchymal stem cells (ADSCs) have therapeutic effects in inflammatory diseases. However, production of extracellular (EVs) ADSCs is costly, inefficient, and time consuming. The anti‐inflammatory properties adipose tissue‐derived EVs other biogenic nanoparticles not been explored. In this study, are obtained directly lipoaspirate, an easily accessible abundant source biological material. Compared to ADSC‐EVs, lipoaspirate...
Pancreatic ductal adenocarcinoma (PDAC) represents one of the most aggressive and lethal malignancies worldwide with an urgent need for new diagnostic therapeutic strategies. One major risk factor PDAC is pre-indication chronic pancreatitis (CP), which highly inflammatory pancreatic tissue. Kallikreins (KLKs) are secreted serine proteases that play important role in various cancers as components tumor microenvironment. Previous studies KLKs solid tumors largely relied on either...
According to the cancer stem cell (CSC) hypothesis, aggressive growth and early metastasis of pancreatic ductal adenocarcinoma (PDA) is due activity CSCs, which are not targeted by current therapies. Otto Warburg suggested that cells driven a high glucose metabolism. Here, we investigated whether glycolysis inhibition targets CSCs thus may enhance therapeutic efficacy. Four established 3 primary PDA lines, non-malignant cells, patient-tumor-derived CSC-enriched spheroidal cultures were...
Surgery remains the only curative option for treatment of pancreatic adenocarcinoma (PDAC). The goal this study was to investigate clinical outcome and prognostic factors in patients after resection ductal head. data from 195 who underwent head PDAC between 1993 2011 our center were retrospectively analyzed. survival operation evaluated using multivariate analysis. surgeries included 69.7% pylorus-preserving pancreatoduodenectomies (PPPD) 30.3% standard Kausch-Whipple (Whipple). overall...
Kallikreins play an important role in tumour microenvironment and as cancer biomarkers different entities. Previous studies suggested upregulation of KLK10 KLK6 pancreatic ductal adenocarcinoma (PDAC). Therefore, we evaluated the clinicopathological these kallikreins their value PDAC. Differential expression was validated by DNA-microarrays immunohistochemistry normal malignant tissues. Sera concentrations both were using ELISA. In silico analysis possible protein interactions gene silencing...
The low prevalence of pancreatic cancer remains an obstacle to the development effective screening tools in asymptomatic population. However, serologic markers still offers potential for improvement diagnostic capabilities, especially subpopulations patients with high risk cancer. accurate identification and exclusion disease those benign disorders remain important goals. While clinical experience largely dismissed many candidate as useful cancer, CA19-9 continues show promise. present...
Necrotising pancreatitis, and particularly infected necrosis, are still associated with high morbidity mortality. Since 2011, a step-up approach lower rates compared to initial open necrosectomy has been established. However, mortality complication of this complex treatment hardly studied thereafter.The German Pancreatitis Study Group performed multicenter, retrospective study including 220 patients necrotising pancreatitis requiring intervention, treated at 10 hospitals in Germany between...
Introduction: The perioperative morbidity following pancreas surgery remains high due to various specific complications: postoperative pancreatic fistula, postpancreatectomy hemorrhage, and delayed gastric emptying. International Study Group of Pancreatic Surgery has defined these complications. aim this study is evaluate the clinical applicability, validate definition, morbidity. Methods: Between 2004 2014, 769 patients underwent resection. Data were collected in a prospective database....
Abstract Extracellular vesicles (EVs) are widely used as natural nanoparticles to deliver various cargos for disease diagnosis and therapy. However, unmodified EVs cannot efficiently transport the desired sites due non‐specific uptake. Here, a delivery system is designed display nanobodies against cadherin 17 (CDH17) on surface of isolated from HEK‐293 cells loaded with dye Indocyanine green (ICG) and/or anti‐cancer drug dinitroazetidine derivative RRx‐001, blocker CD47/ signal regulatory...
Pancreatic ductal adenocarcinoma shows a distinct apoptosis resistance, which contributes significantly to the aggressive nature of this tumor and constrains effectiveness new therapeutic strategies. Apoptosis resistance is determined by net balance cells pro-and anti-apoptotic "control mechanisms". Numerous dysregulated genes have been identified in pancreatic cancer seem contribute high buffering capacity. We aimed compare benefit simultaneous gene silencing (SGS) several candidate with...