A5037449523- Glioma Diagnosis and Treatment
- CNS Lymphoma Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Brain Metastases and Treatment
- Acute Myeloid Leukemia Research
- Epigenetics and DNA Methylation
- Cancer Treatment and Pharmacology
- Calpain Protease Function and Regulation
- Cancer-related gene regulation
- Cutaneous lymphoproliferative disorders research
- Alzheimer's disease research and treatments
- Lung Cancer Diagnosis and Treatment
- RNA Research and Splicing
- Wnt/β-catenin signaling in development and cancer
- Venomous Animal Envenomation and Studies
- Signaling Pathways in Disease
- Lymphadenopathy Diagnosis and Analysis
- Head and Neck Cancer Studies
- Aluminum toxicity and tolerance in plants and animals
- Appendicitis Diagnosis and Management
- Dermatologic Treatments and Research
- Gallbladder and Bile Duct Disorders
- COVID-19 diagnosis using AI
- Cancer Cells and Metastasis
- Advanced Radiotherapy Techniques
Universitätsmedizin Göttingen
2019-2024
University of Göttingen
2022-2024
Max Planck Institute of Experimental Medicine
2011-2020
National Institute of Neurological Disorders and Stroke
2014
National Institutes of Health
2014
Breast cancer has been associated with activation of the WNT signaling pathway, although no driver mutations in genes have found yet. Instead, a high expression alternative receptor ROR2 was observed, particular breast brain metastases. However, its respective ligand and downstream this context remained unknown. We modulated human cells characterized their gene protein by RNA-Seq, qRT-PCR, immunoblots reverse phase array (RPPA) combined network analyses to understand molecular basis cancer....
More than half of all brain metastases show infiltrating rather displacing growth at the macro-metastasis/organ parenchyma interface (MMPI), a finding associated with shorter survival. The lymphoid enhancer-binding factor-1 (LEF1) is an epithelial-mesenchymal transition (EMT) transcription factor that commonly overexpressed in brain-colonizing cancer cells. Here, we LEF1 vivo breast colonization model. It shortened survival, albeit without engaging EMT MMPI. By differential proteome...
Identification of the optimal treatment strategy is challenging in elderly with localized non-small cell lung cancer (NSCLC). Concurrent chemotherapy low-dose cisplatin represents an option for elderly. Outcomes (1) (≥70 years, n = 158) vs. younger patients (n 188) and (2), independently age, definitive radiochemotherapy, 125) cisplatin/vinorelbine 76) were studied. Elderly included more males, had a lower Karnofsky index, comorbidities, stages. Low-dose (vs. cisplatin/vinorelbine) higher We...
Abstract We describe here 11 consecutive patients with recurrence of high-grade glioma treated regorafenib at our university medical center. The majority had MGMT promoter methylation (9/11 cases). Regorafenib was given as 2nd line systemic treatment in 6/11 and 3rd or higher 5/11 patients. median number applied cycles 2 dosage reductions 5/11. Response to observed 4/11 (PR 1/11, SD 3/11). Median overall survival for the cohort 16.1 months, progression-free 9.0 time failure 3.3 months. Side...
Secondary central nervous system lymphoma (SCNSL) is a rare and difficult to treat type of Non-Hodgkin characterized by systemic (CNS) disease manifestations. In this study, 124 patients with SCNSL intensively treated clinical long-term follow-up were included. Initial histopathology, as divided in low-grade, other aggressive, diffuse large B-cell (DLBCL), was prognostic significance. Overall response induction treatment factor early responding DLBCL-SCNSL comparison those non-responding...
The internal organ at risk volume (IRV) concept might improve toxicity profiles in stereotactic body radiation therapy (SBRT) for non-small cell lung cancer (NSCLC). We studied (1) clinical aspects central vs. peripheral tumors, (2) the IRV (3) motion, and (4) associated normal tissue complication probabilities (NTCPs). analyzed patients who received SBRT NSCLC (clinical aspects, n = 78; motion management, 35). found lower biologically effective doses, larger planning target sizes, higher...
Treatment of recurrent malignant ascites in cancer patients is a challenge. Evidence based guidelines regarding the best treatment strategy are lacking. The aim this prospective study was to investigate safety and efficacy tunnelled peritoneal catheter (PleurX) with symptomatic ascites. Patients symptomatic, diuretics-refractory indication for implantation PleurX were prospectively enrolled between August 2018 July 2020. number days, complications, amount drained ascites-associated symptoms...
Abstract The COVID-19 pandemic poses new challenges for the medical community due to its large number of patients presenting with varying symptoms. Chest ultrasound (ChUS) may be particularly useful in early clinical management suspected broad availability and rapid application. We aimed investigate patterns ChUS compare findings results from chest X-ray (CRX). 24 (18 symptomatic, 6 asymptomatic) confirmed SARS-CoV-2 by polymerase chain reaction underwent bedside addition CRX following...
ABSTRACT Breast cancer has been associated with activation of the WNT signaling pathway, although underlying molecular mechanisms are still unclear. Here, we found receptor ROR2 to be highly expressed in aggressive breast tumors and worse metastasis-free survival. In order understand basis these observations, overexpressed human cell lines, inducing a BRCAness-like phenotype rendering them resistant PARP inhibition. High levels were defects morphology cell-cell-contacts leading increased...
<sup>177</sup>Lu-PSMA radioligand therapy is a promising new option for patients with metastasized castration-resistant prostate cancer, and the spectrum of adverse events this treatment has to be evaluated. Here, we describe case patient M1c disease (metastasis mediastinum, lungs, bones, liver) who presented elevated liver enzyme levels after receiving cancer. Pretreatment <sup>68</sup>Ga-PSMA PET/CT showed at least 4 lesions low uptake. Overall, uptake was inhomogeneous. Liver biopsy...
Abstract Purpose Systemic sclerosis (SSc) is a rare autoimmune disease associated with high morbidity and mortality. SSc treatment still challenging, evidence scarce. In the last decades high-dose chemotherapy autologous stem cell transplantation (HD-ASCT) has proven to be effective. However, related mortality (TRM) are high. We conducted retrospective, single-center analysis of patients following HD-ASCT focusing on TRM risk factors. Methods 32 who underwent at our hospital between June...
The acquisition of subsequent genetic lesions (clonal evolution, CE) and/or the expansion existing clones (CEXP) contributes to clonal dynamics (CD) in myelodysplastic syndromes (MDS). Although CD plays an important role high-risk patients disease progression and transformation into acute myeloid leukemia (AML), knowledge about lower-risk MDS (LR-MDS) is limited due lack robust longitudinal data considering long clinically stable courses disease. In this retrospective analysis, we delineate...
Abstract BACKGROUND The phase 2 REGOMA trial suggested a survival benefit of the multikinase inhibitor regorafenib for treatment patients with glioblastoma at first recurrence. Hand-foot skin reactions (HFSR) following therapy have been reported as predictor prolonged in solid tumors. Data on predictive value HFSR recurrent undergoing remain scarce. MATERIAL AND METHODS Fifty-seven (age range, 35-77 years) IDH-wildtype glioblastomas were retrospectively identified from five centers Germany...
Abstract INTRODUCTION The phase 2 REGOMA trial suggested a survival benefit of the multikinase inhibitor regorafenib for treating patients with glioblastoma at first recurrence. Hand-foot skin reactions (HFSR) following therapy have been reported to predict prolonged overall (OS) in solid tumors. predictive value HFSR recurrent undergoing remains be investigated. METHODS Fifty-seven (age range, 35-77 years) IDH-wildtype glioblastomas were retrospectively identified from five centers Germany...
Einleitung Therapierefraktärer Aszites bei Patienten mit fortgeschrittener Tumorerkrankung stellt eine Herausforderung dar. Repetitive Punktionen sind mitunter belastend. Eine Alternative dauerhafte getunnelte Drainage Prospektive Daten zur Effektivität und Sicherheit dieses Verfahrens rar.
Primary lymphomatoid granulomatosis of the CNS (CNS-LG) is a rare lymphoid neoplasia associated Epstein-Barr Virus (EBV) and often accompanied by immunodeficiencies. No treatment standards have been defined yet. However, due to devastating neurologic sequelae based on similarities diffuse large B-cell lymphoma, curative requires intensive therapy protocols resembling applied in lymphoma. Here, clinical courses treatments four primary CNS-LG patients analogy aggressive CNS-lymphomas including...
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