A5077350620- Cancer, Hypoxia, and Metabolism
- Nanoplatforms for cancer theranostics
- MRI in cancer diagnosis
- Hepatocellular Carcinoma Treatment and Prognosis
- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- Lanthanide and Transition Metal Complexes
- Lung Cancer Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Advanced Radiotherapy Techniques
- Head and Neck Cancer Studies
- Gastric Cancer Management and Outcomes
- Angiogenesis and VEGF in Cancer
- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging Techniques and Applications
- Endometrial and Cervical Cancer Treatments
- Radiation Therapy and Dosimetry
- Eicosanoids and Hypertension Pharmacology
- Colorectal Cancer Treatments and Studies
- Cancer Research and Treatments
- Effects of Radiation Exposure
- Genetic factors in colorectal cancer
- Salivary Gland Tumors Diagnosis and Treatment
- Esophageal Cancer Research and Treatment
- Neuroendocrine Tumor Research Advances
University of Göttingen
2013-2025
Universitätsmedizin Göttingen
2015-2025
Research Article10 August 2018Open Access Transparent process Comparative proteomics reveals a diagnostic signature for pulmonary head-and-neck cancer metastasis Hanibal Bohnenberger Institute of Pathology, University Medical Center, Göttingen, Germany Search more papers by this author Lars Kaderali Bioinformatics, Medicine Greifswald, Philipp Ströbel Diego Yepes Department II, Hematology/Oncology, Goethe University, Frankfurt, German Cancer Consortium, Heidelberg, Uwe Plessmann...
Abstract Background Radiation necrosis is a recognized complication following radiotherapy for primary brain tumors, presenting diagnostic and therapeutic challenges, potentially masquerading as tumor recurrence. This study aims to delineate the clinical trajectory, management strategies, outcomes of histologically confirmed radiation in patients treated tumors. Methods We conducted retrospective review who underwent surgical intervention suspected recurrence at our institution between 2010...
In definitive radiotherapy/radiochemotherapy (RT/RCT) for localized non-small cell lung cancer (NSCLC), the introduction of positron-emission tomography (PET)-CT-based staging/RT planning and dynamic RT techniques (intensity-modulated radiotherapy, IMRT/volumetric modulated arc therapy, VMAT) were important innovations. We performed a retrospective study compared clinical outcomes (1) in patients with PET-CT-based staging (n = 170) vs. conventional 103) (2) (IMRT/VMAT; n 99)...
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Excellent dosimetric characteristics were demonstrated for volumetric modulated arc therapy (VMAT) in preoperative chemoradiotherapy (CRT) locally advanced rectal cancer (LARC). In a single-center retrospective analysis, we tested whether these advantages may translate into significant clinical benefits. We compared VMAT to conventional 3D conformal radiotherapy (3DCRT) patients, homogeneously treated according the control arm of CAO/ARO/AIO-04 trial. CRT consisted pelvic irradiation with...
<b><i>Background:</i></b> Little is known about the physical symptoms and psychosocial burden of patients at time diagnosis an incurable situation, although cancer treatment guidelines demand early assessment integration palliative care concepts, beginning from incurability. <b><i>Methods:</i></b> Therefore, we initiated a prospective longitudinal multicenter cohort study assessing needs suffering (various entities), diagnosing incurability...
Intensity-modulated radiotherapy (IMRT) for cervical cancer yields favorable results in terms of oncological outcomes, acute toxicity, and late toxicity. Limited data are available on clinical with volumetric modulated arc therapy (VMAT). This study's purpose is to compare outcome toxicity VMAT conventional 3D conformal (3DCRT), giving special consideration the influence patient- treatment-related parameters side effects.
Identification of the optimal treatment strategy is challenging in elderly with localized non-small cell lung cancer (NSCLC). Concurrent chemotherapy low-dose cisplatin represents an option for elderly. Outcomes (1) (≥70 years, n = 158) vs. younger patients (n 188) and (2), independently age, definitive radiochemotherapy, 125) cisplatin/vinorelbine 76) were studied. Elderly included more males, had a lower Karnofsky index, comorbidities, stages. Low-dose (vs. cisplatin/vinorelbine) higher We...
Objectives/Hypothesis External auditory canal cancer is rare and carries a poor prognosis. To date, only few studies provide evidence for clinical decision making in multimodal treatment. Methods Retrospective chart review of 36 cases three tertiary referral centers. Results Thirteen patients were treated by surgery alone, 18 with adjuvant chemoradiotherapy (CRT) five primary CRT. Clear surgical margins (R0) obtained 19 positive (R1) 12. The 5‐year overall survival local control rates 59.4%...
The internal organ at risk volume (IRV) concept might improve toxicity profiles in stereotactic body radiation therapy (SBRT) for non-small cell lung cancer (NSCLC). We studied (1) clinical aspects central vs. peripheral tumors, (2) the IRV (3) motion, and (4) associated normal tissue complication probabilities (NTCPs). analyzed patients who received SBRT NSCLC (clinical aspects, n = 78; motion management, 35). found lower biologically effective doses, larger planning target sizes, higher...
Abstract Treatment of patients with locally advanced rectal cancer (RC) is based on neoadjuvant chemoradiotherapy followed by surgery. In order to reduce the development therapy resistance, it necessary further improve previous treatment approaches. Recent in vivo experimental studies suggested that reduction tumor hypoxia vessel normalization (TVN), through inhibition glycolytic activator PFKFB3, could significantly response therapy. We have evaluated vitro and effects PFKFB3 inhibitor...
Abstract Background and Aim The German NPC‐GPOH trials introduced treatment including neoadjuvant chemotherapy, radiochemotherapy (RCT) antiviral in patients aged 25 years or younger with nasopharyngeal cancer (NPC). We conducted a retrospective study on outcomes of at the age ≥26 treated accordingly our institution. Methods Consecutive who received primary RCT for NPC were included. Kaplan–Meier method was used to calculate survival probabilities, Cox regression analysis test an influence...
Superior vena cava syndrome (SVCS) often results from external vessel compression due to tumor growth. Urgent symptom-guided radiotherapy (RT) remains a major treatment approach in histologically proven, rapidly progressive disease. Despite several publications, recent data concerning symptom relief and oncological outcome as well potential confounders response are still scarce.We performed retrospective single-center analysis of patients receiving urgent RT between 2000 2021 at the...
Abstract Background Significant bleeding of tumor sites is a dreaded complication in oncological diseases and often results clinical emergencies. Besides basic local interventional procedures, an urgent radiotherapeutic approach can either achieve reduction or stop vast majority patients. In spite being used regularly practice, data reporting to this therapy still scarce. Methods We retrospectively analyzed 77 patients treated for significant tumor-related at our clinic between 2000 2021,...
Abstract Background The question whether lymphocyte radiosensitivity is representative of patients’ response to radiotherapy (RT) remains unsolved. We analyzed cytogenetic damage in patients who were homogeneously treated with preoperative radiochemotherapy (RCT) for rectal cancer within clinical trials. tested interindividual variation and consistent after in-vivo in-vitro irradiation, the effect RCT characteristics on damage, correlations outcome terms tumor response, survival...
The pandemic raised a discussion about the postponement of medical interventions for non-small cell lung cancer (NSCLC). We analyzed characteristics pretreatment diagnostic assessment in and influence on outcomes. A total 96 patients with stereotactic body radiation therapy (SBRT) NSCLC were included. number increased from mean 0.9 (2012-2019) to 1.45 per month COVID era (p < 0.05). Pandemic-related factors (contact reduction, limited intensive care unit resources) might have influenced...